| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 7,350,000 | 20,286,000 | 21.46% | ||
| 2 | BAKER BROS. ADVISORS LP | 5,102,153 | 14,082,000 | 14.90% | ||
| 3 | Avoro Capital Advisors LLC | 3,804,745 | 10,501,000 | 11.11% | ||
| 4 | BlackRock Finance, Inc. | 3,587,286 | 9,901,000 | 10.47% | ||
| 5 | VANGUARD GROUP INC | 3,348,549 | 9,242,000 | 9.78% | ||
| 6 | JPMORGAN CHASE & CO | 1,536,300 | 4,240,000 | 4.49% | ||
| 7 | STATE STREET CORP | 938,195 | 2,590,000 | 2.74% | ||
| 8 | KENNEDY CAPITAL MANAGEMENT LLC | 918,438 | 2,535,000 | 2.68% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 891,800 | 2,461,000 | 2.60% | ||
| 10 | NORTHERN TRUST CORP | 802,566 | 2,215,000 | 2.34% | ||
| 11 | AJO, LP | 658,974 | 1,819,000 | 1.92% | ||
| 12 | DEUTSCHE BANK AG\ | 652,611 | 1,800,000 | 1.90% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 613,849 | 1,694,000 | 1.79% | ||
| 14 | Candriam S.C.A. | 560,000 | 1,546,000 | 1.64% | ||
| 15 | KNOTT DAVID M | 355,750 | 982,000 | 1.04% | ||
| 16 | FMR LLC | 300,000 | 828,000 | 0.88% | ||
| 17 | TANAKA CAPITAL MANAGEMENT INC | 241,078 | 665,000 | 0.70% | ||
| 18 | Bank of New York Mellon Corp | 211,979 | 585,000 | 0.62% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 191,273 | 528,000 | 0.56% | ||
| 20 | ROYAL BANK OF CANADA | 165,041 | 455,000 | 0.48% | ||
| 21 | HAP Trading, LLC | 315,000 | 399,000 | 0.42% | Call | |
| 22 | CORRADO ADVISORS, LLC | 136,550 | 377,000 | 0.40% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,000 | 373,000 | 0.39% | Call | |
| 24 | TEACHERS ADVISORS, LLC | 126,696 | 350,000 | 0.37% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 126,700 | 350,000 | 0.37% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,500 | 333,000 | 0.35% | ||
| 27 | MORGAN STANLEY | 98,774 | 273,000 | 0.29% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 86,168 | 238,000 | 0.25% | ||
| 29 | Virtu KCG Holdings LLC | 85,907 | 237,000 | 0.25% | ||
| 30 | RHUMBLINE ADVISERS | 75,701 | 209,000 | 0.22% | ||
| 31 | BOOTHBAY FUND MANAGEMENT, LLC | 68,970 | 190,000 | 0.20% | ||
| 32 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,114 | 175,000 | 0.19% | ||
| 33 | Squarepoint Ops LLC | 60,500 | 167,000 | 0.18% | ||
| 34 | Weiss Multi-Strategy Advisers LLC | 60,000 | 166,000 | 0.18% | ||
| 35 | STATE OF WISCONSIN INVESTMENT BOARD | 54,000 | 149,000 | 0.16% | ||
| 36 | AMERICAN INTERNATIONAL GROUP, INC. | 44,379 | 122,000 | 0.13% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,332 | 114,000 | 0.12% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 41,400 | 114,000 | 0.12% | ||
| 39 | Nationwide Fund Advisors | 40,137 | 111,000 | 0.12% | ||
| 40 | VOYA INVESTMENT MANAGEMENT LLC | 32,973 | 91,000 | 0.10% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 27,226 | 74,000 | 0.08% | ||
| 42 | First Allied Advisory Services, Inc. | 26,000 | 72,000 | 0.08% | ||
| 43 | Commonwealth Equity Services, Inc | 23,815 | 66,000 | 0.07% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 22,564 | 62,000 | 0.07% | ||
| 45 | HBK Sorce Advisory LLC | 21,109 | 58,000 | 0.06% | ||
| 46 | Malaga Cove Capital, LLC | 20,000 | 56,000 | 0.06% | ||
| 47 | ProVise Management Group, LLC | 19,000 | 52,000 | 0.06% | ||
| 48 | GOLDMAN SACHS GROUP INC | 18,852 | 52,000 | 0.06% | ||
| 49 | RUSSELL INVESTMENTS GROUP, LTD. | 17,696 | 49,000 | 0.05% | ||
| 50 | BARCLAYS PLC | 16,079 | 44,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
