| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,979,977 | 38,041,000 | 21.17% | ||
| 2 | Redmile Group, LLC | 4,207,575 | 22,931,000 | 12.76% | ||
| 3 | BlackRock Finance, Inc. | 2,862,098 | 15,599,000 | 8.68% | ||
| 4 | VANGUARD GROUP INC | 1,748,447 | 9,529,000 | 5.30% | ||
| 5 | MORGAN STANLEY | 1,723,590 | 9,393,000 | 5.23% | ||
| 6 | DIMENSIONAL FUND ADVISORS LP | 1,448,250 | 7,893,000 | 4.39% | ||
| 7 | Opaleye Management Inc. | 1,280,000 | 6,976,000 | 3.88% | ||
| 8 | Numeric Investors LLC | 1,271,253 | 6,928,000 | 3.85% | ||
| 9 | ArrowMark Colorado Holdings LLC | 1,270,082 | 6,922,000 | 3.85% | ||
| 10 | Sessa Capital IM, L.P. | 940,291 | 5,125,000 | 2.85% | ||
| 11 | STATE STREET CORP | 828,936 | 4,515,000 | 2.51% | ||
| 12 | NORTHERN TRUST CORP | 696,440 | 3,795,000 | 2.11% | ||
| 13 | D. E. Shaw & Co., Inc. | 507,299 | 2,765,000 | 1.54% | ||
| 14 | Artal Group S.A. | 500,000 | 2,725,000 | 1.52% | ||
| 15 | Aisling Capital LLC | 472,943 | 2,578,000 | 1.43% | ||
| 16 | Rhenman & Partners Asset Management AB | 400,000 | 2,180,000 | 1.21% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 346,575 | 1,888,000 | 1.05% | ||
| 18 | PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 304,771 | 1,661,000 | 0.92% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 279,000 | 1,521,000 | 0.85% | Call | |
| 20 | AXA S.A. | 258,573 | 1,409,000 | 0.78% | ||
| 21 | Bank of New York Mellon Corp | 253,367 | 1,381,000 | 0.77% | ||
| 22 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 236,350 | 1,288,000 | 0.72% | ||
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 233,950 | 1,275,000 | 0.71% | ||
| 24 | VICTORY CAPITAL MANAGEMENT INC | 229,544 | 1,251,000 | 0.70% | ||
| 25 | QS Investors, LLC | 226,678 | 1,235,000 | 0.69% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 205,987 | 1,123,000 | 0.62% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 178,490 | 973,000 | 0.54% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 167,677 | 914,000 | 0.51% | ||
| 29 | 683 Capital Management, LLC | 160,000 | 872,000 | 0.49% | ||
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 139,427 | 760,000 | 0.42% | ||
| 31 | BAKER BROS. ADVISORS LP | 115,216 | 628,000 | 0.35% | ||
| 32 | Invesco Ltd. | 111,115 | 606,000 | 0.34% | ||
| 33 | JANE STREET GROUP, LLC | 110,000 | 600,000 | 0.33% | Call | |
| 34 | TFS CAPITAL LLC | 107,764 | 587,000 | 0.33% | ||
| 35 | TEACHERS ADVISORS, LLC | 107,179 | 584,000 | 0.32% | ||
| 36 | DEUTSCHE BANK AG\ | 99,892 | 542,000 | 0.30% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 94,624 | 516,000 | 0.29% | ||
| 38 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 84,300 | 459,000 | 0.26% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,516 | 450,000 | 0.25% | ||
| 40 | TWO SIGMA ADVISERS, LP | 80,000 | 436,000 | 0.24% | ||
| 41 | Granite Investment Partners, LLC | 79,753 | 435,000 | 0.24% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,200 | 421,000 | 0.23% | ||
| 43 | FT OPTIONS LLC | 75,239 | 410,000 | 0.23% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 73,663 | 401,000 | 0.22% | ||
| 45 | A.R.T. Advisors, LLC | 72,723 | 396,000 | 0.22% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 70,200 | 383,000 | 0.21% | ||
| 47 | BARCLAYS PLC | 68,956 | 376,000 | 0.21% | ||
| 48 | Swiss National Bank | 65,800 | 359,000 | 0.20% | ||
| 49 | JACOBS LEVY EQUITY MANAGEMENT, INC | 65,580 | 357,000 | 0.20% | ||
| 50 | CITADEL ADVISORS LLC | 60,482 | 329,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
