| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 5,808,439 | 187,612,000 | 15.42% | ||
| 2 | BlackRock Finance, Inc. | 5,001,406 | 161,545,000 | 13.28% | ||
| 3 | FMR LLC | 3,335,997 | 107,753,000 | 8.86% | ||
| 4 | STATE STREET CORP | 1,763,387 | 56,962,000 | 4.68% | ||
| 5 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 1,750,000 | 56,525,000 | 4.65% | ||
| 6 | EcoR1 Capital, LLC | 1,585,457 | 51,210,000 | 4.21% | ||
| 7 | JANUS HENDERSON GROUP PLC | 1,412,799 | 45,633,000 | 3.75% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,120,000 | 36,176,000 | 2.97% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 1,072,000 | 34,626,000 | 2.85% | ||
| 10 | JPMORGAN CHASE & CO | 1,070,781 | 34,586,000 | 2.84% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 805,453 | 26,016,000 | 2.14% | ||
| 12 | NORTHERN TRUST CORP | 734,483 | 23,724,000 | 1.95% | ||
| 13 | Omega Fund Management, LLC | 627,492 | 20,268,000 | 1.67% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 548,877 | 17,728,000 | 1.46% | ||
| 15 | TEACHERS ADVISORS, LLC | 536,279 | 17,322,000 | 1.42% | ||
| 16 | PRUDENTIAL FINANCIAL INC | 448,780 | 14,496,000 | 1.19% | ||
| 17 | NORGES BANK | 420,768 | 13,591,000 | 1.12% | ||
| 18 | GOLDMAN SACHS GROUP INC | 413,372 | 13,352,000 | 1.10% | ||
| 19 | Candriam S.C.A. | 361,000 | 11,661,000 | 0.96% | ||
| 20 | Opaleye Management Inc. | 360,000 | 11,628,000 | 0.96% | ||
| 21 | OppenheimerFunds, Inc. | 356,406 | 11,512,000 | 0.95% | ||
| 22 | Invesco Ltd. | 338,178 | 10,924,000 | 0.90% | ||
| 23 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 329,371 | 10,638,000 | 0.87% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 306,494 | 9,900,000 | 0.81% | ||
| 25 | Bank of New York Mellon Corp | 292,636 | 9,452,000 | 0.78% | ||
| 26 | Rock Springs Capital Management LP | 280,000 | 9,044,000 | 0.74% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 272,574 | 8,805,000 | 0.72% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 251,400 | 8,120,000 | 0.67% | Put | |
| 29 | FORESITE CAPITAL MANAGEMENT III, LLC | 250,000 | 8,075,000 | 0.66% | ||
| 30 | AMERICAN CENTURY COMPANIES INC | 246,440 | 7,960,000 | 0.65% | ||
| 31 | HANDELSBANKEN FONDER AB | 239,000 | 7,720,000 | 0.63% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 227,300 | 7,342,000 | 0.60% | ||
| 33 | Nationwide Fund Advisors | 214,799 | 6,938,000 | 0.57% | ||
| 34 | PANAGORA ASSET MANAGEMENT INC | 214,750 | 6,936,000 | 0.57% | ||
| 35 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 209,155 | 6,755,706 | 0.56% | ||
| 36 | MORGAN STANLEY | 185,993 | 6,007,000 | 0.49% | ||
| 37 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 181,025 | 5,847,000 | 0.48% | ||
| 38 | BOSTON ADVISORS LLC | 175,005 | 5,653,000 | 0.46% | ||
| 39 | SPHERA FUNDS MANAGEMENT LTD. | 165,700 | 5,352,000 | 0.44% | ||
| 40 | Rhenman & Partners Asset Management AB | 154,341 | 4,985,000 | 0.41% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 145,610 | 4,703,000 | 0.39% | ||
| 42 | STRS OHIO | 143,000 | 4,618,000 | 0.38% | ||
| 43 | PRINCIPAL FINANCIAL GROUP INC | 139,465 | 4,504,000 | 0.37% | ||
| 44 | WELLINGTON MANAGEMENT GROUP LLP | 117,066 | 3,781,000 | 0.31% | ||
| 45 | CASTLEARK MANAGEMENT LLC | 115,760 | 3,739,000 | 0.31% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,288 | 3,401,000 | 0.28% | ||
| 47 | Swiss National Bank | 99,100 | 3,201,000 | 0.26% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 93,200 | 3,010,000 | 0.25% | ||
| 49 | JACOBS LEVY EQUITY MANAGEMENT, INC | 88,314 | 2,853,000 | 0.23% | ||
| 50 | ClariVest Asset Management LLC | 83,713 | 2,704,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
