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IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC. Institutional holdings reported to the SEC.

Institutional Holders (2017Q2)
Portfolio Summary: 315 Institutional holders with a total value of $5,772,701,525.
#
Manager Name
Shares
Value ($)
%
Options
Notes
51 Swiss National Bank 201,900 10,271,000 0.18%
52 AVIVA PLC 200,258 10,187,000 0.18%
53 DIMENSIONAL FUND ADVISORS LP 196,812 10,014,000 0.17%
54 BARCLAYS PLC 180,800 9,197,000 0.16% Call
55 ARK INVESTMENT MANAGEMENT LLC 176,991 9,004,000 0.16%
56 ROYAL BANK OF CANADA 176,010 8,953,000 0.16%
57 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 170,976 8,698,000 0.15%
58 RHUMBLINE ADVISERS 158,084 8,042,000 0.14%
59 TEACHERS ADVISORS, LLC 150,656 7,664,000 0.13%
60 CANADA PENSION PLAN INVESTMENT BOARD 148,000 7,529,000 0.13%
61 GROUP ONE TRADING LLC 141,934 7,220,000 0.13%
62 SCOUT INVESTMENTS, INC. 138,545 7,048,000 0.12%
63 Artal Group S.A. 135,000 6,867,000 0.12%
64 CITIGROUP INC 133,461 6,790,000 0.12%
65 NATIXIS ADVISORS, LLC 130,015 6,614,000 0.11%
66 SONORA INVESTMENT MANAGEMENT, LLC 119,858 6,097,176 0.11%
67 CITADEL ADVISORS LLC 115,828 5,892,000 0.10%
68 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 111,862 5,690,000 0.10%
69 Candriam S.C.A. 110,000 5,596,000 0.10%
70 State of New Jersey Common Pension Fund D 100,000 5,087,000 0.09%
71 PARAMETRIC PORTFOLIO ASSOCIATES LLC 98,914 5,032,000 0.09%
72 GUGGENHEIM CAPITAL LLC 98,439 5,007,000 0.09%
73 MILLENNIUM MANAGEMENT LLC 96,719 4,920,000 0.09%
74 NOMURA HOLDINGS INC 93,764 4,775,000 0.08%
75 Quantitative Investment Management, LLC 91,000 4,629,000 0.08%
76 DAVENPORT & Co LLC 90,518 4,604,651 0.08%
77 CAPITAL FUND MANAGEMENT S.A. 87,120 4,432,000 0.08%
78 Curi Capital, LLC 83,105 4,228,000 0.07%
79 RENAISSANCE TECHNOLOGIES LLC 82,414 4,192,000 0.07%
80 TANAKA CAPITAL MANAGEMENT INC 81,937 4,168,000 0.07%
81 WOLVERINE ASSET MANAGEMENT LLC 78,600 3,998,000 0.07% Put
82 RAINIER INVESTMENT MANAGEMENT LLC 76,930 3,913,000 0.07%
83 BARCLAYS PLC 76,700 3,902,000 0.07% Put
84 Nationwide Fund Advisors 76,457 3,889,000 0.07%
85 Majedie Asset Management Ltd 74,196 3,774,000 0.07%
86 ALLIANCEBERNSTEIN L.P. 73,287 3,728,000 0.06%
87 Nuveen Asset Management, LLC 69,653 3,543,000 0.06%
88 CITIGROUP INC 68,900 3,505,000 0.06% Put
89 UBS Group AG 67,965 3,457,000 0.06%
90 ProShare Advisors LLC 66,230 3,369,000 0.06%
91 BLB&B Advisors, LLC 63,142 3,212,000 0.06%
92 APG Asset Management N.V. 62,464 3,178,000 0.06%
93 BRIDGEWAY CAPITAL MANAGEMENT, LLC 59,800 3,042,000 0.05%
94 CITADEL ADVISORS LLC 54,500 2,772,000 0.05% Call
95 DekaBank Deutsche Girozentrale 53,276 2,760,000 0.05%
96 D. E. Shaw & Co., Inc. 53,864 2,740,000 0.05%
97 Janney Montgomery Scott LLC 52,263 2,659,000 0.05%
98 CLINTON GROUP INC 52,232 2,657,000 0.05%
99 INTERNATIONAL BIOTECHNOLOGY TRUST PLC 51,500 2,620,000 0.05%
100 SEI INVESTMENTS CO 51,357 2,613,000 0.05%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.