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IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC. Institutional holdings reported to the SEC.

Institutional Holders (2017Q2)
Portfolio Summary: 315 Institutional holders with a total value of $5,772,701,525.
#
Manager Name
Shares
Value ($)
%
Options
Notes
201 ELLINGTON MANAGEMENT GROUP LLC 6,800 346,000 0.01%
202 GOFEN & GLOSSBERG LLC /IL/ 6,660 339,000 0.01%
203 ETRADE Capital Management LLC 6,633 337,000 0.01%
204 Brown Advisory Securities, LLC 6,575 335,000 0.01%
205 SG Americas Securities, LLC 6,315 321,000 0.01%
206 Campbell & CO Investment Adviser LLC 6,059 308,000 0.01%
207 BOSTON ADVISORS LLC 5,960 303,000 0.01%
208 Parametrica Management Ltd 5,849 298,000 0.01%
209 IFP ADVISORS, INC 5,680 289,000 0.01%
210 World Asset Management Inc 5,614 286,000 0.00%
211 C WorldWide Group Holding A/S 5,535 282,000 0.00%
212 RAYMOND JAMES TRUST N.A. 5,553 282,000 0.00%
213 HL FINANCIAL SERVICES LLC 5,500 280,000 0.00%
214 First Allied Advisory Services, Inc. 5,463 279,000 0.00%
215 SUSQUEHANNA INTERNATIONAL GROUP, LLP 5,415 275,000 0.00%
216 BLAIR WILLIAM & CO/IL 5,381 274,000 0.00%
217 First City Capital Management, Inc. 5,330 271,000 0.00%
218 FDx Advisors, Inc. 5,272 268,000 0.00%
219 DUPONT CAPITAL MANAGEMENT CORP 5,184 264,000 0.00%
220 Private Advisor Group, LLC 5,102 263,000 0.00%
221 US BANCORP \DE\ 5,152 262,000 0.00%
222 SOMERVILLE KURT F 5,079 258,000 0.00%
223 BANK OF MONTREAL /CAN/ 5,071 258,000 0.00%
224 CAPSTONE ASSET MANAGEMENT CO 5,018 255,000 0.00%
225 EQUITEC SPECIALISTS, LLC 5,000 254,000 0.00% Put
226 Cheyne Capital Management (UK) LLP 4,891 249,000 0.00%
227 Zurcher Kantonalbank (Zurich Cantonalbank) 4,880 248,000 0.00%
228 Trexquant Investment LP 4,580 233,000 0.00%
229 PRELUDE CAPITAL MANAGEMENT, LLC 4,570 232,000 0.00%
230 JANE STREET GROUP, LLC 4,465 227,000 0.00%
231 FORESTERS INVESTMENT MANAGEMENT COMPANY, INC. 4,361 222,000 0.00%
232 Cambridge Investment Research Advisors, Inc. 4,362 222,000 0.00%
233 REGIONS FINANCIAL CORP 4,321 220,000 0.00%
234 Squarepoint Ops LLC 4,328 220,000 0.00%
235 SPOT TRADING LLC /BD 4,100 209,000 0.00% Call
236 QS Investors, LLC 4,010 204,000 0.00%
237 WFG Advisors, LP 3,800 193,000 0.00%
238 MANUFACTURERS LIFE INSURANCE COMPANY, THE 3,744 190,000 0.00%
239 HANSEATIC MANAGEMENT SERVICES INC 3,481 177,000 0.00%
240 AMERICAN INTERNATIONAL GROUP, INC. 2,994 152,000 0.00%
241 MOSAIC FAMILY WEALTH, LLC 2,635 134,000 0.00%
242 SIMPLEX TRADING, LLC 2,631 133,000 0.00%
243 PARALLEL ADVISORS, LLC 2,073 109,000 0.00%
244 YORKBRIDGE WEALTH PARTNERS, LLC 2,031 106,000 0.00%
245 STEWARD PARTNERS INVESTMENT ADVISORY, LLC 1,975 100,000 0.00%
246 Kistler-Tiffany Companies, LLC 1,900 97,000 0.00%
247 KBC Group NV 1,869 95,000 0.00%
248 JPMORGAN CHASE & CO 1,809 92,000 0.00%
249 FLORENCE CAPITAL ADVISORS, LLC 2,000 92,000 0.00%
250 BALENTINE LLC 1,716 87,000 0.00%
Page 5 of 7

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.