| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,076,367 | 42,977,000 | 19.59% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 2,168,691 | 30,297,000 | 13.81% | ||
| 3 | BlackRock Finance, Inc. | 1,889,109 | 26,390,000 | 12.03% | ||
| 4 | FMR LLC | 1,341,644 | 18,743,000 | 8.54% | ||
| 5 | JENNISON ASSOCIATES LLC | 953,862 | 13,325,000 | 6.07% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 761,203 | 10,634,000 | 4.85% | ||
| 7 | VANGUARD GROUP INC | 512,624 | 7,161,000 | 3.26% | ||
| 8 | ArrowMark Colorado Holdings LLC | 466,427 | 6,516,000 | 2.97% | ||
| 9 | JPMORGAN CHASE & CO | 439,070 | 6,134,000 | 2.80% | ||
| 10 | ORBIMED ADVISORS LLC | 437,000 | 6,105,000 | 2.78% | ||
| 11 | Alyeska Investment Group, L.P. | 325,000 | 4,540,000 | 2.07% | ||
| 12 | Artal Group S.A. | 300,000 | 4,191,000 | 1.91% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 296,310 | 4,139,000 | 1.89% | ||
| 14 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 245,449 | 3,429,000 | 1.56% | ||
| 15 | BOXER CAPITAL, LLC | 234,220 | 3,272,000 | 1.49% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 225,000 | 3,143,000 | 1.43% | ||
| 17 | Tekla Capital Management LLC | 200,000 | 2,794,000 | 1.27% | ||
| 18 | Ghost Tree Capital, LLC | 200,000 | 2,794,000 | 1.27% | ||
| 19 | J. Goldman & Co LP | 147,181 | 2,056,000 | 0.94% | ||
| 20 | TIVERTON ASSET MANAGEMENT LLC | 137,732 | 1,924,000 | 0.88% | ||
| 21 | NORTHERN TRUST CORP | 130,196 | 1,819,000 | 0.83% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 125,999 | 1,760,000 | 0.80% | ||
| 23 | MORGAN STANLEY | 125,215 | 1,749,000 | 0.80% | ||
| 24 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 109,168 | 1,525,000 | 0.70% | ||
| 25 | Vident Investment Advisory, LLC | 103,558 | 1,447,000 | 0.66% | ||
| 26 | STATE STREET CORP | 81,327 | 1,137,000 | 0.52% | ||
| 27 | MEADOW CREEK INVESTMENT MANAGEMENT LLC | 57,222 | 799,000 | 0.36% | ||
| 28 | Crestline Management, LP | 55,368 | 773,000 | 0.35% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,500 | 705,000 | 0.32% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,484 | 691,000 | 0.31% | ||
| 31 | ELKFORK PARTNERS LLC | 47,124 | 658,000 | 0.30% | ||
| 32 | Bank of New York Mellon Corp | 44,025 | 615,000 | 0.28% | ||
| 33 | GLEN HARBOR CAPITAL MANAGEMENT LLC | 37,026 | 517,000 | 0.24% | ||
| 34 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 36,565 | 511,000 | 0.23% | ||
| 35 | KORNITZER CAPITAL MANAGEMENT INC /KS | 28,800 | 402,000 | 0.18% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 27,689 | 387,000 | 0.18% | ||
| 37 | NEUBURGH ADVISERS LLC | 26,928 | 376,000 | 0.17% | ||
| 38 | OPPENHEIMER & CO INC | 26,499 | 370,000 | 0.17% | ||
| 39 | DEUTSCHE BANK AG\ | 25,468 | 354,000 | 0.16% | ||
| 40 | ALPS ADVISORS INC | 19,853 | 277,000 | 0.13% | ||
| 41 | BOOTHBAY FUND MANAGEMENT, LLC | 15,689 | 219,000 | 0.10% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,587 | 218,000 | 0.10% | ||
| 43 | TEACHERS ADVISORS, LLC | 15,451 | 216,000 | 0.10% | ||
| 44 | DIMENSIONAL FUND ADVISORS LP | 13,743 | 192,000 | 0.09% | ||
| 45 | BANK OF MONTREAL /CAN/ | 11,329 | 158,000 | 0.07% | ||
| 46 | C WorldWide Group Holding A/S | 11,100 | 155,000 | 0.07% | ||
| 47 | Airain ltd | 10,751 | 150,000 | 0.07% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,100 | 142,000 | 0.06% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 9,400 | 131,000 | 0.06% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 5,467 | 76,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
