| 1 |
Fortress Investment Group LLC |
4,085,469 |
22,511,000 |
33.25% |
|
|
| 2 |
PUTNAM INVESTMENTS LLC |
1,976,757 |
10,892,000 |
16.09% |
|
|
| 3 |
FMR LLC |
928,881 |
5,118,000 |
7.56% |
|
|
| 4 |
PRUDENTIAL PLC |
905,339 |
4,988,000 |
7.37% |
|
|
| 5 |
ACUTA CAPITAL PARTNERS, LLC |
568,137 |
3,130,000 |
4.62% |
|
|
| 6 |
MORGAN STANLEY |
552,680 |
3,045,000 |
4.50% |
|
|
| 7 |
Alyeska Investment Group, L.P. |
510,972 |
2,815,000 |
4.16% |
|
|
| 8 |
PERCEPTIVE ADVISORS LLC |
560,000 |
2,808,000 |
4.15% |
|
|
| 9 |
Avoro Capital Advisors LLC |
468,148 |
2,579,000 |
3.81% |
|
|
| 10 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
302,923 |
1,669,000 |
2.47% |
|
|
| 11 |
C WorldWide Group Holding A/S |
295,184 |
1,626,000 |
2.40% |
|
|
| 12 |
Opaleye Management Inc. |
265,000 |
1,460,000 |
2.16% |
|
|
| 13 |
ELLIOTT MANAGEMENT CORP |
170,391 |
939,000 |
1.39% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
169,037 |
931,000 |
1.38% |
|
|
| 15 |
HIGHLAND CAPITAL MANAGEMENT LP |
160,000 |
881,000 |
1.30% |
|
|
| 16 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
130,000 |
716,000 |
1.06% |
|
|
| 17 |
DAFNA Capital Management LLC |
100,000 |
551,000 |
0.81% |
|
|
| 18 |
MACKENZIE FINANCIAL CORP |
66,625 |
367,000 |
0.54% |
|
|
| 19 |
Geduld E E |
26,506 |
146,000 |
0.22% |
|
|
| 20 |
Laurion Capital Management LP |
24,200 |
133,000 |
0.20% |
|
|
| 21 |
Fiduciary Trust Co International of Pennsylvania |
20,725 |
114,000 |
0.17% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
18,300 |
101,000 |
0.15% |
|
|
| 23 |
PARTNERS CAPITAL INVESTMENT GROUP (HOLDINGS), LLC |
17,526 |
97,000 |
0.14% |
|
|
| 24 |
HOWLAND CAPITAL MANAGEMENT LLC |
10,000 |
55,000 |
0.08% |
|
|
| 25 |
WELLS FARGO & COMPANY/MN |
2,500 |
14,000 |
0.02% |
|
|
| 26 |
Tower Research Capital LLC (TRC) |
1,645 |
9,000 |
0.01% |
|
|
