| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEUTSCHE BANK AG\ | 600 | 0 | 0.00% | ||
| 2 | BARCLAYS PLC | 10 | 0 | 0.00% | ||
| 3 | Creative Planning | 100 | 0 | 0.00% | ||
| 4 | BANK OF AMERICA CORP /DE/ | 400 | 1,000 | 0.00% | ||
| 5 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 791 | 1,000 | 0.00% | ||
| 6 | ROYAL BANK OF CANADA | 1,375 | 2,000 | 0.00% | ||
| 7 | Tower Research Capital LLC (TRC) | 1,606 | 2,000 | 0.00% | ||
| 8 | UBS Group AG | 2,905 | 4,000 | 0.01% | ||
| 9 | MORGAN STANLEY | 2,439 | 4,000 | 0.01% | ||
| 10 | JPMORGAN CHASE & CO | 4,042 | 6,000 | 0.01% | ||
| 11 | WELLS FARGO & COMPANY/MN | 9,162 | 14,000 | 0.03% | ||
| 12 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 11,598 | 18,000 | 0.04% | ||
| 13 | ACADIAN ASSET MANAGEMENT LLC | 13,930 | 21,000 | 0.04% | ||
| 14 | Connor, Clark & Lunn Investment Management Ltd. | 14,800 | 23,000 | 0.05% | ||
| 15 | TFS CAPITAL LLC | 15,468 | 24,000 | 0.05% | ||
| 16 | CONNABLE OFFICE INC | 15,861 | 24,000 | 0.05% | ||
| 17 | RBF Capital, LLC | 24,800 | 38,000 | 0.08% | ||
| 18 | Squarepoint Ops LLC | 28,300 | 43,000 | 0.09% | ||
| 19 | RAYMOND JAMES TRUST N.A. | 29,030 | 44,000 | 0.09% | ||
| 20 | Virtu KCG Holdings LLC | 31,682 | 48,000 | 0.10% | ||
| 21 | WEDBUSH SECURITIES INC | 35,000 | 54,000 | 0.11% | ||
| 22 | Minerva Advisors LLC | 31,880 | 58,000 | 0.12% | ||
| 23 | SHEPHERD KAPLAN KROCHUK, LLC | 38,000 | 58,000 | 0.12% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 38,853 | 59,000 | 0.12% | ||
| 25 | BLAIR WILLIAM & CO/IL | 45,948 | 70,000 | 0.15% | ||
| 26 | D. E. Shaw & Co., Inc. | 85,194 | 130,000 | 0.28% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 112,500 | 172,000 | 0.36% | ||
| 28 | VHCP MANAGEMENT II, LLC | 130,798 | 200,000 | 0.42% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134,300 | 205,000 | 0.43% | ||
| 30 | PANAGORA ASSET MANAGEMENT INC | 163,247 | 250,000 | 0.53% | ||
| 31 | FMR LLC | 197,100 | 302,000 | 0.64% | ||
| 32 | SECTORAL ASSET MANAGEMENT INC | 201,660 | 309,000 | 0.65% | ||
| 33 | GREENLEAF TRUST | 214,109 | 328,000 | 0.69% | ||
| 34 | DAFNA Capital Management LLC | 265,000 | 405,000 | 0.86% | ||
| 35 | NEXTHERA CAPITAL LP | 400,000 | 612,000 | 1.30% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 546,984 | 837,000 | 1.77% | ||
| 37 | PNC FINANCIAL SERVICES GROUP, INC. | 746,738 | 1,142,000 | 2.42% | ||
| 38 | SABBY MANAGEMENT, LLC | 1,746,261 | 2,672,000 | 5.66% | ||
| 39 | VIVO CAPITAL, LLC | 2,438,270 | 3,731,000 | 7.90% | ||
| 40 | New Leaf Venture Partners, L.L.C. | 2,592,593 | 3,967,000 | 8.40% | ||
| 41 | ORBIMED ADVISORS LLC | 3,703,704 | 5,667,000 | 12.00% | ||
| 42 | PERCEPTIVE ADVISORS LLC | 3,703,704 | 5,667,000 | 12.00% | ||
| 43 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,972,319 | 7,608,000 | 16.11% | ||
| 44 | FRAZIER MANAGEMENT LLC | 8,112,121 | 12,412,000 | 26.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
