| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 8,584,128 | 95,799,000 | 28.20% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,450,538 | 38,507,000 | 11.34% | ||
| 3 | BVF INC/IL | 2,970,182 | 33,147,000 | 9.76% | ||
| 4 | FRANKLIN RESOURCES INC | 1,859,079 | 20,747,000 | 6.11% | ||
| 5 | JENNISON ASSOCIATES LLC | 1,593,707 | 17,786,000 | 5.24% | ||
| 6 | FMR LLC | 1,503,600 | 16,780,000 | 4.94% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,376,887 | 15,366,000 | 4.52% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,362,810 | 15,209,000 | 4.48% | ||
| 9 | VANGUARD GROUP INC | 844,190 | 9,421,000 | 2.77% | ||
| 10 | Redmile Group, LLC | 599,620 | 6,692,000 | 1.97% | ||
| 11 | BAKER BROS. ADVISORS LP | 563,312 | 6,287,000 | 1.85% | ||
| 12 | SCHONFELD STRATEGIC ADVISORS LLC | 541,034 | 6,038,000 | 1.78% | ||
| 13 | JANUS HENDERSON GROUP PLC | 501,632 | 5,598,000 | 1.65% | ||
| 14 | BlackRock Finance, Inc. | 484,759 | 5,409,000 | 1.59% | ||
| 15 | Alyeska Investment Group, L.P. | 350,000 | 3,906,000 | 1.15% | ||
| 16 | Informed Momentum Co LLC | 338,745 | 3,780,000 | 1.11% | ||
| 17 | ORBIMED ADVISORS LLC | 337,588 | 3,767,000 | 1.11% | ||
| 18 | SPHERA FUNDS MANAGEMENT LTD. | 320,796 | 3,580,000 | 1.05% | ||
| 19 | Point72 Asset Management, L.P. | 292,289 | 3,262,000 | 0.96% | ||
| 20 | Rock Springs Capital Management LP | 225,000 | 2,511,000 | 0.74% | ||
| 21 | Broadfin Capital, LLC | 221,848 | 2,476,000 | 0.73% | ||
| 22 | Artal Group S.A. | 202,500 | 2,260,000 | 0.67% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 145,802 | 1,627,000 | 0.48% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 135,803 | 1,516,000 | 0.45% | ||
| 25 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 109,066 | 1,217,000 | 0.36% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,900 | 1,115,000 | 0.33% | Put | |
| 27 | AMERIPRISE FINANCIAL INC | 96,343 | 1,075,000 | 0.32% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,151 | 1,040,000 | 0.31% | ||
| 29 | Bank of New York Mellon Corp | 92,911 | 1,037,000 | 0.31% | ||
| 30 | GOLDMAN SACHS GROUP INC | 86,430 | 965,000 | 0.28% | ||
| 31 | ELEMENT CAPITAL MANAGEMENT LLC | 83,459 | 931,000 | 0.27% | ||
| 32 | Hudson Bay Capital Management LP | 80,150 | 894,000 | 0.26% | ||
| 33 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 77,229 | 862,000 | 0.25% | ||
| 34 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 70,162 | 783,000 | 0.23% | ||
| 35 | MONASHEE INVESTMENT MANAGEMENT LLC | 70,000 | 781,000 | 0.23% | ||
| 36 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 66,764 | 745,000 | 0.22% | ||
| 37 | DEUTSCHE BANK AG\ | 60,641 | 676,000 | 0.20% | ||
| 38 | Virtu KCG Holdings LLC | 50,943 | 569,000 | 0.17% | ||
| 39 | NORTHERN TRUST CORP | 45,759 | 510,000 | 0.15% | ||
| 40 | Paloma Partners Management Co | 44,900 | 501,000 | 0.15% | ||
| 41 | Private Capital Advisors, Inc. | 40,000 | 446,000 | 0.13% | ||
| 42 | TD ASSET MANAGEMENT INC | 32,400 | 362,000 | 0.11% | ||
| 43 | Endurant Capital Management LP | 31,907 | 356,000 | 0.10% | ||
| 44 | RUSSELL INVESTMENTS GROUP, LTD. | 31,379 | 350,000 | 0.10% | ||
| 45 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 30,100 | 336,000 | 0.10% | Call | |
| 46 | BARCLAYS PLC | 27,737 | 309,000 | 0.09% | ||
| 47 | VIRTUS ETF ADVISERS LLC | 26,312 | 294,000 | 0.09% | ||
| 48 | STATE STREET CORP | 24,870 | 278,000 | 0.08% | ||
| 49 | CITADEL ADVISORS LLC | 22,311 | 249,000 | 0.07% | ||
| 50 | CREDIT SUISSE AG/ | 17,110 | 191,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
