| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,972,016 | 53,624,000 | 27.55% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,440,716 | 34,243,000 | 17.60% | ||
| 3 | Redmile Group, LLC | 1,138,370 | 15,971,000 | 8.21% | ||
| 4 | PFM Health Sciences, LP | 698,159 | 9,795,000 | 5.03% | ||
| 5 | PHARMSTANDARD INTERNATIONAL S.A. | 662,063 | 9,289,000 | 4.77% | ||
| 6 | Omega Fund Management, LLC | 579,650 | 8,132,000 | 4.18% | ||
| 7 | BlackRock Finance, Inc. | 360,229 | 5,054,000 | 2.60% | ||
| 8 | Cormorant Asset Management, LP | 359,738 | 5,047,000 | 2.59% | SH | |
| 9 | BROWN ADVISORY INC | 305,058 | 4,279,000 | 2.20% | ||
| 10 | VANGUARD GROUP INC | 255,060 | 3,578,000 | 1.84% | ||
| 11 | Artal Group S.A. | 250,000 | 3,508,000 | 1.80% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 247,872 | 3,478,000 | 1.79% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 204,746 | 2,873,000 | 1.48% | ||
| 14 | Alyeska Investment Group, L.P. | 182,422 | 2,559,000 | 1.31% | ||
| 15 | ACADIAN ASSET MANAGEMENT LLC | 168,199 | 2,359,000 | 1.21% | ||
| 16 | CASDIN CAPITAL, LLC | 160,000 | 2,245,000 | 1.15% | ||
| 17 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 130,000 | 1,824,000 | 0.94% | ||
| 18 | AMERIPRISE FINANCIAL INC | 126,908 | 1,781,000 | 0.92% | ||
| 19 | Spark Investment Management LLC | 125,300 | 1,757,000 | 0.90% | ||
| 20 | Foresite Capital Management II, LLC | 119,912 | 1,682,000 | 0.86% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114,972 | 1,613,057 | 0.83% | ||
| 22 | Fosun International Ltd | 92,610 | 1,456,000 | 0.75% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 100,926 | 1,415,000 | 0.73% | ||
| 24 | STATE STREET CORP | 100,233 | 1,409,000 | 0.72% | ||
| 25 | BAKER BROS. ADVISORS LP | 100,000 | 1,403,000 | 0.72% | ||
| 26 | CONNING INC. | 92,610 | 1,299,000 | 0.67% | ||
| 27 | NORTHERN TRUST CORP | 90,412 | 1,269,000 | 0.65% | ||
| 28 | GOLDMAN SACHS GROUP INC | 69,648 | 977,000 | 0.50% | ||
| 29 | Vident Investment Advisory, LLC | 68,692 | 964,000 | 0.50% | ||
| 30 | PRUDENTIAL FINANCIAL INC | 68,280 | 958,000 | 0.49% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,532 | 905,000 | 0.47% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 53,212 | 747,000 | 0.38% | ||
| 33 | JPMORGAN CHASE & CO | 42,900 | 602,000 | 0.31% | ||
| 34 | STRS OHIO | 37,300 | 523,000 | 0.27% | ||
| 35 | AMERICAN CENTURY COMPANIES INC | 32,240 | 452,000 | 0.23% | ||
| 36 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 30,488 | 428,000 | 0.22% | ||
| 37 | Hutchin Hill Capital, LP | 30,100 | 422,000 | 0.22% | ||
| 38 | ALPS ADVISORS INC | 29,032 | 407,000 | 0.21% | ||
| 39 | Bank of New York Mellon Corp | 25,574 | 359,000 | 0.18% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,219 | 340,000 | 0.17% | ||
| 41 | WELLS FARGO & COMPANY/MN | 20,970 | 294,000 | 0.15% | ||
| 42 | D. E. Shaw & Co., Inc. | 19,323 | 271,000 | 0.14% | ||
| 43 | VIRTUS ETF ADVISERS LLC | 18,442 | 259,000 | 0.13% | ||
| 44 | MONASHEE INVESTMENT MANAGEMENT LLC | 17,773 | 249,000 | 0.13% | ||
| 45 | Alberta Investment Management Corp | 16,900 | 237,000 | 0.12% | ||
| 46 | CITADEL ADVISORS LLC | 14,245 | 200,000 | 0.10% | ||
| 47 | DEUTSCHE BANK AG\ | 13,638 | 189,000 | 0.10% | ||
| 48 | Swiss National Bank | 13,400 | 188,000 | 0.10% | ||
| 49 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 12,600 | 177,000 | 0.09% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 12,600 | 177,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
