| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | Fosun International Ltd | 92,610 | 1,456,000 | 0.75% | ||
| 52 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114,972 | 1,613,057 | 0.83% | ||
| 53 | Foresite Capital Management II, LLC | 119,912 | 1,682,000 | 0.86% | ||
| 54 | Spark Investment Management LLC | 125,300 | 1,757,000 | 0.90% | ||
| 55 | AMERIPRISE FINANCIAL INC | 126,908 | 1,781,000 | 0.92% | ||
| 56 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 130,000 | 1,824,000 | 0.94% | ||
| 57 | CASDIN CAPITAL, LLC | 160,000 | 2,245,000 | 1.15% | ||
| 58 | ACADIAN ASSET MANAGEMENT LLC | 168,199 | 2,359,000 | 1.21% | ||
| 59 | Alyeska Investment Group, L.P. | 182,422 | 2,559,000 | 1.31% | ||
| 60 | MILLENNIUM MANAGEMENT LLC | 204,746 | 2,873,000 | 1.48% | ||
| 61 | DEERFIELD MANAGEMENT COMPANY, L.P. | 247,872 | 3,478,000 | 1.79% | ||
| 62 | Artal Group S.A. | 250,000 | 3,508,000 | 1.80% | ||
| 63 | VANGUARD GROUP INC | 255,060 | 3,578,000 | 1.84% | ||
| 64 | BROWN ADVISORY INC | 305,058 | 4,279,000 | 2.20% | ||
| 65 | Cormorant Asset Management, LP | 359,738 | 5,047,000 | 2.59% | SH | |
| 66 | BlackRock Finance, Inc. | 360,229 | 5,054,000 | 2.60% | ||
| 67 | Omega Fund Management, LLC | 579,650 | 8,132,000 | 4.18% | ||
| 68 | PHARMSTANDARD INTERNATIONAL S.A. | 662,063 | 9,289,000 | 4.77% | ||
| 69 | PFM Health Sciences, LP | 698,159 | 9,795,000 | 5.03% | ||
| 70 | Redmile Group, LLC | 1,138,370 | 15,971,000 | 8.21% | ||
| 71 | WELLINGTON MANAGEMENT GROUP LLP | 2,440,716 | 34,243,000 | 17.60% | ||
| 72 | FMR LLC | 3,972,016 | 53,624,000 | 27.55% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
