| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRAZIER MANAGEMENT LLC | 3,688,448 | 102,354,000 | 26.35% | ||
| 2 | Novo Holdings A/S | 3,033,504 | 84,180,000 | 21.67% | ||
| 3 | BVF INC/IL | 1,738,600 | 48,246,000 | 12.42% | ||
| 4 | Cormorant Asset Management, LP | 895,626 | 24,854,000 | 6.40% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 881,957 | 24,474,000 | 6.30% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 845,746 | 23,469,000 | 6.04% | ||
| 7 | FRANKLIN RESOURCES INC | 279,200 | 7,748,000 | 1.99% | ||
| 8 | MARSHALL WACE ASIA LTD | 247,275 | 6,924,000 | 1.78% | ||
| 9 | MARSHALL WACE NORTH AMERICA, L.P. | 247,275 | 6,924,000 | 1.78% | ||
| 10 | BlackRock Finance, Inc. | 248,219 | 6,888,000 | 1.77% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 245,000 | 6,799,000 | 1.75% | ||
| 12 | FEDERATED HERMES, INC. | 200,000 | 5,550,000 | 1.43% | ||
| 13 | VANGUARD GROUP INC | 168,099 | 4,665,000 | 1.20% | ||
| 14 | BAKER BROS. ADVISORS LP | 150,000 | 4,163,000 | 1.07% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 149,506 | 4,149,000 | 1.07% | ||
| 16 | ACUTA CAPITAL PARTNERS, LLC | 165,690 | 4,138,000 | 1.07% | ||
| 17 | JPMORGAN CHASE & CO | 138,738 | 3,851,000 | 0.99% | ||
| 18 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 100,500 | 2,789,000 | 0.72% | ||
| 19 | GRATICULE ASIA MACRO ADVISORS LLC | 93,250 | 2,588,000 | 0.67% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 54,865 | 1,522,000 | 0.39% | ||
| 21 | Alyeska Investment Group, L.P. | 52,250 | 1,450,000 | 0.37% | ||
| 22 | Iguana Healthcare Management, LLC | 50,000 | 1,388,000 | 0.36% | ||
| 23 | BOXER CAPITAL, LLC | 50,000 | 1,388,000 | 0.36% | ||
| 24 | Artal Group S.A. | 44,690 | 1,240,000 | 0.32% | ||
| 25 | STATE STREET CORP | 35,837 | 995,000 | 0.26% | ||
| 26 | Spark Investment Management LLC | 34,700 | 962,000 | 0.25% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 25,500 | 708,000 | 0.18% | ||
| 28 | Polar Capital LLP | 25,000 | 694,000 | 0.18% | ||
| 29 | MONASHEE INVESTMENT MANAGEMENT LLC | 25,000 | 694,000 | 0.18% | PRN | |
| 30 | Bank of New York Mellon Corp | 13,447 | 373,000 | 0.10% | ||
| 31 | NORTHERN TRUST CORP | 13,037 | 362,000 | 0.09% | ||
| 32 | MORGAN STANLEY | 11,160 | 310,000 | 0.08% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 9,988 | 278,000 | 0.07% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,000 | 278,000 | 0.07% | ||
| 35 | Endurant Capital Management LP | 9,300 | 258,000 | 0.07% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 8,181 | 227,000 | 0.06% | ||
| 37 | TEACHERS ADVISORS, LLC | 7,713 | 214,000 | 0.06% | ||
| 38 | DAFNA Capital Management LLC | 4,500 | 125,000 | 0.03% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 4,433 | 123,000 | 0.03% | ||
| 40 | STRS OHIO | 1,500 | 41,000 | 0.01% | ||
| 41 | DEUTSCHE BANK AG\ | 1,452 | 39,000 | 0.01% | ||
| 42 | BARCLAYS PLC | 931 | 26,000 | 0.01% | ||
| 43 | Ameritas Investment Partners, Inc. | 420 | 12,000 | 0.00% | ||
| 44 | FNY Managed Accounts LLC | 340 | 9,000 | 0.00% | ||
| 45 | ROYAL BANK OF CANADA | 300 | 8,000 | 0.00% | ||
| 46 | Legal & General Group Plc | 300 | 5,000 | 0.00% | ||
| 47 | CITIGROUP INC | 140 | 4,000 | 0.00% | ||
| 48 | UBS Group AG | 113 | 3,000 | 0.00% | ||
| 49 | WELLS FARGO & COMPANY/MN | 100 | 3,000 | 0.00% | ||
| 50 | Catalyst Capital Advisors LLC | 70 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
