| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ROYAL BANK OF CANADA | 56 | 1,000 | 0.00% | ||
| 2 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 73 | 2,000 | 0.00% | ||
| 3 | Ameritas Investment Partners, Inc. | 420 | 10,000 | 0.00% | ||
| 4 | BARCLAYS PLC | 504 | 12,000 | 0.00% | ||
| 5 | BNP PARIBAS FINANCIAL MARKETS | 528 | 12,635 | 0.00% | ||
| 6 | CANADA LIFE ASSURANCE Co | 600 | 14,000 | 0.00% | ||
| 7 | Legal & General Group Plc | 1,213 | 29,000 | 0.01% | ||
| 8 | STRS OHIO | 1,500 | 35,000 | 0.01% | ||
| 9 | CITIGROUP INC | 1,852 | 44,000 | 0.01% | ||
| 10 | Nationwide Fund Advisors | 3,102 | 74,000 | 0.02% | ||
| 11 | AMERICAN INTERNATIONAL GROUP, INC. | 3,315 | 79,000 | 0.02% | ||
| 12 | UBS Group AG | 3,351 | 80,000 | 0.02% | ||
| 13 | WELLS FARGO & COMPANY/MN | 3,810 | 91,000 | 0.03% | ||
| 14 | BANK OF AMERICA CORP /DE/ | 5,039 | 121,000 | 0.04% | ||
| 15 | MORGAN STANLEY | 5,064 | 121,000 | 0.04% | ||
| 16 | DAFNA Capital Management LLC | 5,500 | 132,000 | 0.04% | ||
| 17 | NEW YORK STATE COMMON RETIREMENT FUND | 7,000 | 168,000 | 0.05% | ||
| 18 | Magnetar Financial LLC | 8,383 | 201,000 | 0.06% | ||
| 19 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,500 | 227,000 | 0.07% | ||
| 20 | TEACHERS ADVISORS, LLC | 9,520 | 228,000 | 0.07% | ||
| 21 | Swiss National Bank | 10,100 | 242,000 | 0.07% | ||
| 22 | GOLDMAN SACHS GROUP INC | 11,569 | 277,000 | 0.08% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 13,844 | 331,000 | 0.10% | ||
| 24 | ALPS ADVISORS INC | 18,210 | 436,000 | 0.13% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,402 | 465,000 | 0.14% | ||
| 26 | Bank of New York Mellon Corp | 19,744 | 473,000 | 0.14% | ||
| 27 | MONASHEE INVESTMENT MANAGEMENT LLC | 25,000 | 598,000 | 0.18% | ||
| 28 | Polar Capital LLP | 30,000 | 718,000 | 0.22% | ||
| 29 | DEUTSCHE BANK AG\ | 45,806 | 1,093,000 | 0.33% | ||
| 30 | GRATICULE ASIA MACRO ADVISORS LLC | 48,250 | 1,155,000 | 0.35% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 48,392 | 1,158,000 | 0.35% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 56,672 | 1,356,000 | 0.41% | ||
| 33 | JPMORGAN CHASE & CO | 59,100 | 1,414,000 | 0.43% | ||
| 34 | NORTHERN TRUST CORP | 60,042 | 1,436,000 | 0.44% | ||
| 35 | Iguana Healthcare Management, LLC | 70,000 | 1,675,000 | 0.51% | ||
| 36 | Spark Investment Management LLC | 74,100 | 1,773,000 | 0.54% | ||
| 37 | STATE STREET CORP | 74,833 | 1,791,000 | 0.55% | ||
| 38 | BAKER BROS. ADVISORS LP | 117,211 | 2,805,000 | 0.86% | ||
| 39 | ACUTA CAPITAL PARTNERS, LLC | 165,690 | 3,965,000 | 1.21% | ||
| 40 | FEDERATED HERMES, INC. | 200,000 | 4,786,000 | 1.46% | ||
| 41 | VANGUARD GROUP INC | 206,031 | 4,931,000 | 1.50% | ||
| 42 | MARSHALL WACE NORTH AMERICA, L.P. | 210,936 | 5,062,000 | 1.54% | ||
| 43 | Artal Group S.A. | 250,000 | 5,983,000 | 1.82% | ||
| 44 | FRANKLIN RESOURCES INC | 279,200 | 6,681,000 | 2.04% | ||
| 45 | BlackRock Finance, Inc. | 302,156 | 7,231,000 | 2.20% | ||
| 46 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 531,676 | 12,723,000 | 3.88% | ||
| 47 | DEERFIELD MANAGEMENT COMPANY, L.P. | 552,859 | 13,230,000 | 4.03% | ||
| 48 | Cormorant Asset Management, LP | 799,469 | 19,131,000 | 5.83% | SH | |
| 49 | PERCEPTIVE ADVISORS LLC | 952,269 | 22,788,000 | 6.95% | ||
| 50 | BVF INC/IL | 1,659,200 | 39,705,000 | 12.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
