| 1 |
NOMURA ASSET MANAGEMENT CO LTD |
0 |
0 |
0.00% |
|
|
| 2 |
Catalyst Capital Advisors LLC |
85 |
1,000 |
0.00% |
|
|
| 3 |
Tower Research Capital LLC (TRC) |
1,703 |
18,000 |
0.01% |
|
|
| 4 |
Cubist Systematic Strategies, LLC |
2,789 |
29,000 |
0.02% |
|
|
| 5 |
Point72 Hong Kong Ltd |
5,317 |
55,000 |
0.04% |
|
|
| 6 |
Baker Avenue Asset Management, LP |
10,000 |
104,000 |
0.07% |
|
|
| 7 |
Paloma Partners Management Co |
12,557 |
131,000 |
0.09% |
|
|
| 8 |
Iguana Healthcare Management, LLC |
25,000 |
260,000 |
0.17% |
|
|
| 9 |
DAFNA Capital Management LLC |
25,000 |
260,000 |
0.17% |
|
|
| 10 |
Point72 Asset Management, L.P. |
38,534 |
401,000 |
0.26% |
|
|
| 11 |
Spark Investment Management LLC |
49,800 |
518,000 |
0.34% |
|
|
| 12 |
NORGES BANK |
50,000 |
520,000 |
0.34% |
|
|
| 13 |
NEXTHERA CAPITAL LP |
50,000 |
521,000 |
0.34% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
50,984 |
531,000 |
0.35% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
69,152 |
720,000 |
0.47% |
|
|
| 16 |
SECTORAL ASSET MANAGEMENT INC |
75,500 |
786,000 |
0.52% |
|
|
| 17 |
CITADEL ADVISORS LLC |
90,045 |
937,000 |
0.61% |
|
|
| 18 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
97,700 |
1,017,000 |
0.67% |
|
|
| 19 |
New Leaf Venture Partners, L.L.C. |
200,000 |
2,082,000 |
1.37% |
|
|
| 20 |
SPHERA FUNDS MANAGEMENT LTD. |
211,086 |
2,197,000 |
1.44% |
|
|
| 21 |
Rock Springs Capital Management LP |
838,634 |
8,730,000 |
5.73% |
|
|
| 22 |
ORBIMED ADVISORS LLC |
2,605,531 |
27,124,000 |
17.80% |
|
|
| 23 |
Novo Holdings A/S |
3,044,093 |
31,689,000 |
20.79% |
|
|
| 24 |
NEA Management Company, LLC |
3,336,563 |
34,734,000 |
22.79% |
|
|
| 25 |
SOFINNOVA MANAGEMENT VIII, L.L.C. |
3,749,623 |
39,034,000 |
25.61% |
|
|
