| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 2,448,350 | 61,209,000 | 18.25% | ||
| 2 | VHCP MANAGEMENT II, LLC | 1,664,300 | 37,930,000 | 11.31% | ||
| 3 | FMR LLC | 1,035,523 | 25,888,000 | 7.72% | ||
| 4 | BlackRock Finance, Inc. | 1,020,932 | 25,523,000 | 7.61% | ||
| 5 | Knoll Capital Management, LLC | 807,224 | 20,181,000 | 6.02% | ||
| 6 | JANUS HENDERSON GROUP PLC | 645,743 | 16,144,000 | 4.81% | ||
| 7 | JPMORGAN CHASE & CO | 593,225 | 14,831,000 | 4.42% | ||
| 8 | EMERALD ADVISERS, LLC | 497,880 | 12,447,000 | 3.71% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 496,128 | 12,403,000 | 3.70% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 435,209 | 10,880,000 | 3.24% | ||
| 11 | STIFEL FINANCIAL CORP | 415,200 | 10,381,000 | 3.09% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 356,107 | 8,904,000 | 2.65% | ||
| 13 | EMERALD MUTUAL FUND ADVISERS TRUST | 352,560 | 8,814,000 | 2.63% | ||
| 14 | Rock Springs Capital Management LP | 307,000 | 7,675,000 | 2.29% | ||
| 15 | YALE UNIVERSITY | 250,000 | 6,250,000 | 1.86% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 216,761 | 5,419,000 | 1.62% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 164,904 | 4,122,000 | 1.23% | ||
| 18 | Alyeska Investment Group, L.P. | 149,651 | 3,741,000 | 1.12% | ||
| 19 | VANGUARD GROUP INC | 128,102 | 3,202,000 | 0.95% | ||
| 20 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 120,000 | 3,000,000 | 0.89% | ||
| 21 | PERCEPTIVE ADVISORS LLC | 120,000 | 3,000,000 | 0.89% | ||
| 22 | STATE STREET CORP | 117,212 | 2,934,000 | 0.87% | ||
| 23 | NORTHERN TRUST CORP | 113,027 | 2,826,000 | 0.84% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 98,318 | 2,458,000 | 0.73% | ||
| 25 | Nicholas Investment Partners, LP | 96,218 | 2,406,000 | 0.72% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 85,798 | 2,145,000 | 0.64% | ||
| 27 | Laurion Capital Management LP | 85,625 | 2,141,000 | 0.64% | ||
| 28 | GILDER GAGNON HOWE & CO LLC | 77,169 | 1,929,000 | 0.58% | ||
| 29 | EcoR1 Capital, LLC | 70,000 | 1,750,000 | 0.52% | ||
| 30 | AMERICAN CENTURY COMPANIES INC | 56,390 | 1,410,000 | 0.42% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 53,240 | 1,331,000 | 0.40% | ||
| 32 | Bank of New York Mellon Corp | 52,357 | 1,308,000 | 0.39% | ||
| 33 | NORGES BANK | 50,000 | 1,250,000 | 0.37% | ||
| 34 | MONASHEE INVESTMENT MANAGEMENT LLC | 49,390 | 1,235,000 | 0.37% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,332 | 909,000 | 0.27% | ||
| 36 | ALPS ADVISORS INC | 30,897 | 772,000 | 0.23% | ||
| 37 | FORESITE CAPITAL MANAGEMENT III, LLC | 30,000 | 750,000 | 0.22% | ||
| 38 | WELLS FARGO & COMPANY/MN | 26,213 | 655,000 | 0.20% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 18,994 | 475,000 | 0.14% | ||
| 40 | TEACHERS ADVISORS, LLC | 17,789 | 445,000 | 0.13% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,700 | 443,000 | 0.13% | ||
| 42 | PANAGORA ASSET MANAGEMENT INC | 16,300 | 408,000 | 0.12% | ||
| 43 | RAYMOND JAMES & ASSOCIATES | 15,710 | 393,000 | 0.12% | ||
| 44 | RUSSELL INVESTMENTS GROUP, LTD. | 15,535 | 388,000 | 0.12% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 13,618 | 340,000 | 0.10% | ||
| 46 | DEUTSCHE BANK AG\ | 13,131 | 326,000 | 0.10% | ||
| 47 | MORGAN STANLEY | 11,562 | 289,000 | 0.09% | ||
| 48 | Tower Research Capital LLC (TRC) | 11,001 | 275,000 | 0.08% | ||
| 49 | RHUMBLINE ADVISERS | 10,272 | 257,000 | 0.08% | ||
| 50 | DESCHUTES PORTFOLIO STRATEGY, LLC | 10,000 | 250,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
