| 1 |
Polaris Venture Management Co. V, L.L.C. |
2,018,253 |
17,337,000 |
46.39% |
|
|
| 2 |
Opaleye Management Inc. |
450,000 |
3,865,500 |
10.34% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
361,700 |
3,107,000 |
8.31% |
|
|
| 4 |
PRINCIPAL FINANCIAL GROUP INC |
303,581 |
2,607,000 |
6.98% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
274,000 |
2,354,000 |
6.30% |
|
|
| 6 |
VANGUARD GROUP INC |
178,850 |
1,536,000 |
4.11% |
|
|
| 7 |
Rhenman & Partners Asset Management AB |
108,535 |
932,000 |
2.49% |
|
|
| 8 |
BLACKROCK ADVISORS LLC |
100,787 |
866,000 |
2.32% |
|
|
| 9 |
CREDIT SUISSE AG/ |
80,100 |
689,000 |
1.84% |
|
|
| 10 |
PRICE T ROWE ASSOCIATES INC /MD/ |
65,125 |
559,000 |
1.50% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
57,692 |
496,000 |
1.33% |
|
|
| 12 |
HAMILTON LANE ADVISORS LLC |
36,500 |
314,000 |
0.84% |
|
|
| 13 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
33,717 |
290,000 |
0.78% |
|
|
| 14 |
RAYMOND JAMES & ASSOCIATES |
32,100 |
276,000 |
0.74% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
28,681 |
246,000 |
0.66% |
|
|
| 16 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
26,400 |
227,000 |
0.61% |
|
|
| 17 |
THOMPSON DAVIS & CO., INC. |
24,425 |
210,000 |
0.56% |
|
|
| 18 |
SSI INVESTMENT MANAGEMENT LLC |
22,915 |
197,000 |
0.53% |
|
|
| 19 |
TFS CAPITAL LLC |
20,529 |
176,000 |
0.47% |
|
|
| 20 |
AlpInvest Partners B.V. |
18,923 |
163,000 |
0.44% |
|
|
| 21 |
PRELUDE CAPITAL MANAGEMENT, LLC |
16,000 |
137,000 |
0.37% |
|
|
| 22 |
Virtu KCG Holdings LLC |
15,808 |
136,000 |
0.36% |
|
|
| 23 |
BANQUE PICTET & CIE SA |
15,705 |
135,000 |
0.36% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
15,284 |
131,000 |
0.35% |
|
|
| 25 |
BlackRock Fund Advisors |
15,080 |
130,000 |
0.35% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
6,953 |
60,000 |
0.16% |
|
|
| 27 |
CITIGROUP INC |
5,789 |
50,000 |
0.13% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
5,476 |
47,000 |
0.13% |
|
|
| 29 |
UBS AG |
3,063 |
26,000 |
0.07% |
|
|
| 30 |
BlackRock Japan Co. Ltd |
2,311 |
20,000 |
0.05% |
|
|
| 31 |
ROYAL BANK OF CANADA |
1,750 |
15,000 |
0.04% |
|
|
| 32 |
BlackRock Investment Management, LLC |
1,257 |
11,000 |
0.03% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
968 |
8,000 |
0.02% |
|
|
| 34 |
MORGAN STANLEY |
700 |
6,000 |
0.02% |
|
|
| 35 |
Stevens First Principles Investment Advisors |
500 |
4,000 |
0.01% |
|
|
| 36 |
BNP PARIBAS FINANCIAL MARKETS |
324 |
2,783 |
0.01% |
|
|
| 37 |
PNC FINANCIAL SERVICES GROUP, INC. |
200 |
2,000 |
0.01% |
|
|
| 38 |
MSI Financial Services Inc |
200 |
2,000 |
0.01% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
137 |
1,000 |
0.00% |
|
|
| 40 |
BARCLAYS PLC |
63 |
1,000 |
0.00% |
|
|
