| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,404,572 | 35,616,000 | 25.90% | ||
| 2 | BB BIOTECH AG | 2,463,522 | 16,235,000 | 11.81% | ||
| 3 | BlackRock Fund Advisors | 1,399,074 | 9,220,000 | 6.71% | ||
| 4 | VANGUARD GROUP INC | 1,032,244 | 6,803,000 | 4.95% | ||
| 5 | PINNACLE ASSOCIATES LTD | 987,223 | 6,506,000 | 4.73% | ||
| 6 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 868,052 | 5,720,000 | 4.16% | ||
| 7 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 641,200 | 4,226,000 | 3.07% | Put | |
| 8 | STATE STREET CORP | 605,674 | 3,992,000 | 2.90% | ||
| 9 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 523,100 | 3,447,000 | 2.51% | Put | |
| 10 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 522,800 | 3,445,000 | 2.51% | ||
| 11 | TANG CAPITAL MANAGEMENT LLC | 465,763 | 3,069,000 | 2.23% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 423,577 | 2,791,000 | 2.03% | ||
| 13 | NORTHERN TRUST CORP | 404,097 | 2,663,000 | 1.94% | ||
| 14 | A.R.T. Advisors, LLC | 305,975 | 2,016,000 | 1.47% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 282,388 | 1,861,000 | 1.35% | ||
| 16 | GUGGENHEIM CAPITAL LLC | 210,605 | 1,388,000 | 1.01% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 210,200 | 1,385,000 | 1.01% | ||
| 18 | Jefferies Group LLC | 210,000 | 1,384,000 | 1.01% | Put | |
| 19 | Invesco Ltd. | 199,205 | 1,313,000 | 0.95% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 195,753 | 1,290,000 | 0.94% | ||
| 21 | Bank of New York Mellon Corp | 195,350 | 1,288,000 | 0.94% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,700 | 1,000,000 | 0.73% | Call | |
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 147,875 | 974,000 | 0.71% | ||
| 24 | DEUTSCHE BANK AG\ | 114,449 | 753,000 | 0.55% | ||
| 25 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 112,307 | 741,000 | 0.54% | ||
| 26 | BAILARD, INC. | 111,000 | 731,000 | 0.53% | ||
| 27 | Spot Trading L.L.C | 110,100 | 726,000 | 0.53% | Put | |
| 28 | MORGAN STANLEY | 109,604 | 722,000 | 0.53% | ||
| 29 | BlackRock Investment Management, LLC | 107,595 | 709,000 | 0.52% | ||
| 30 | Employees Retirement System of Texas | 101,000 | 666,000 | 0.48% | ||
| 31 | GOLDMAN SACHS GROUP INC | 100,884 | 665,000 | 0.48% | ||
| 32 | WELLS FARGO & COMPANY/MN | 99,739 | 657,000 | 0.48% | ||
| 33 | ROYAL BANK OF CANADA | 90,317 | 595,000 | 0.43% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,024 | 581,000 | 0.42% | ||
| 35 | Jefferies Group LLC | 87,500 | 577,000 | 0.42% | Call | |
| 36 | GOLDMAN SACHS GROUP INC | 85,300 | 562,000 | 0.41% | Put | |
| 37 | Jefferies Group LLC | 79,813 | 526,000 | 0.38% | ||
| 38 | CITADEL ADVISORS LLC | 79,024 | 521,000 | 0.38% | ||
| 39 | ALGERT GLOBAL LLC | 78,650 | 518,000 | 0.38% | ||
| 40 | Spot Trading L.L.C | 72,800 | 480,000 | 0.35% | Call | |
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,649 | 446,000 | 0.32% | ||
| 42 | Numeric Investors LLC | 57,912 | 382,000 | 0.28% | ||
| 43 | DUPONT CAPITAL MANAGEMENT CORP | 57,850 | 381,000 | 0.28% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,708 | 353,000 | 0.26% | ||
| 45 | AQR CAPITAL MANAGEMENT LLC | 52,200 | 344,000 | 0.25% | ||
| 46 | TEACHERS ADVISORS, LLC | 51,294 | 338,000 | 0.25% | ||
| 47 | Rhenman & Partners Asset Management AB | 49,297 | 325,000 | 0.24% | ||
| 48 | Nationwide Fund Advisors | 44,536 | 293,000 | 0.21% | ||
| 49 | ProShare Advisors LLC | 43,262 | 285,000 | 0.21% | ||
| 50 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 43,302 | 285,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
