| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | OppenheimerFunds, Inc. | 24,400,000 | 294,508,000 | 20.44% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 18,137,786 | 218,923,000 | 15.19% | ||
| 3 | VANGUARD GROUP INC | 8,119,924 | 98,008,000 | 6.80% | ||
| 4 | FIRST TRUST ADVISORS LP | 6,136,021 | 74,062,000 | 5.14% | ||
| 5 | FEDERATED HERMES, INC. | 5,871,200 | 70,865,000 | 4.92% | ||
| 6 | JPMORGAN CHASE & CO | 4,428,675 | 53,453,000 | 3.71% | ||
| 7 | BlackRock Fund Advisors | 4,306,099 | 51,975,000 | 3.61% | ||
| 8 | STATE STREET CORP | 4,163,202 | 50,246,000 | 3.49% | ||
| 9 | Bank of New York Mellon Corp | 3,549,480 | 42,841,000 | 2.97% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,453,213 | 41,680,000 | 2.89% | ||
| 11 | Granahan Investment Management, LLC | 3,442,980 | 41,557,000 | 2.88% | ||
| 12 | Invesco Ltd. | 1,837,754 | 22,182,000 | 1.54% | ||
| 13 | NEA Management Company, LLC | 1,825,600 | 22,035,000 | 1.53% | ||
| 14 | Artal Group S.A. | 1,650,000 | 19,916,000 | 1.38% | ||
| 15 | NORTHERN TRUST CORP | 1,450,229 | 17,504,000 | 1.21% | ||
| 16 | FRANKLIN RESOURCES INC | 1,304,619 | 15,747,000 | 1.09% | ||
| 17 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 1,227,587 | 14,816,000 | 1.03% | ||
| 18 | NORGES BANK | 1,184,581 | 14,298,000 | 0.99% | ||
| 19 | VOYA INVESTMENT MANAGEMENT LLC | 1,181,657 | 14,262,000 | 0.99% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 1,181,048 | 14,255,000 | 0.99% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 867,827 | 10,475,000 | 0.73% | ||
| 22 | Allianz Asset Management GmbH | 833,660 | 10,062,000 | 0.70% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 753,273 | 9,092,000 | 0.63% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 736,250 | 8,886,000 | 0.62% | ||
| 25 | TIRSCHWELL & LOEWY INC | 603,441 | 7,284,000 | 0.51% | ||
| 26 | FMR LLC | 602,903 | 7,277,000 | 0.50% | ||
| 27 | MORGAN STANLEY | 557,428 | 6,729,000 | 0.47% | ||
| 28 | Numeric Investors LLC | 530,534 | 6,404,000 | 0.44% | ||
| 29 | Rhenman & Partners Asset Management AB | 508,000 | 6,132,000 | 0.43% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 506,453 | 6,113,000 | 0.42% | ||
| 31 | ALTRINSIC GLOBAL ADVISORS LLC | 460,000 | 5,552,000 | 0.39% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 457,407 | 5,521,000 | 0.38% | ||
| 33 | Cormorant Asset Management, LP | 450,000 | 5,432,000 | 0.38% | ||
| 34 | BLAIR WILLIAM & CO/IL | 388,860 | 4,693,000 | 0.33% | ||
| 35 | RICE HALL JAMES & ASSOCIATES, LLC | 385,244 | 4,650,000 | 0.32% | ||
| 36 | CREDIT SUISSE AG/ | 382,722 | 4,620,000 | 0.32% | ||
| 37 | CITADEL ADVISORS LLC | 377,144 | 4,552,000 | 0.32% | ||
| 38 | BlackRock Investment Management, LLC | 371,110 | 4,479,000 | 0.31% | ||
| 39 | JACOBS LEVY EQUITY MANAGEMENT, INC | 361,786 | 4,367,000 | 0.30% | ||
| 40 | AXA S.A. | 348,813 | 4,210,000 | 0.29% | ||
| 41 | PRICE T ROWE ASSOCIATES INC /MD/ | 343,300 | 4,144,000 | 0.29% | ||
| 42 | GOLDMAN SACHS GROUP INC | 334,800 | 4,041,000 | 0.28% | Call | |
| 43 | Tekla Capital Management LLC | 334,800 | 4,041,000 | 0.28% | Call | |
| 44 | Tekla Capital Management LLC | 334,800 | 4,041,000 | 0.28% | ||
| 45 | AMERICAN CENTURY COMPANIES INC | 318,773 | 3,848,000 | 0.27% | ||
| 46 | GOLDMAN SACHS GROUP INC | 306,886 | 3,704,000 | 0.26% | ||
| 47 | PRINCIPAL FINANCIAL GROUP INC | 306,530 | 3,700,000 | 0.26% | ||
| 48 | MILLENNIUM MANAGEMENT LLC | 281,511 | 3,398,000 | 0.24% | ||
| 49 | PRUDENTIAL FINANCIAL INC | 281,173 | 3,394,000 | 0.24% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 270,600 | 3,266,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
