| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 7,000,000 | 32,200,000 | 14.89% | ||
| 2 | FMR LLC | 4,463,302 | 20,531,000 | 9.50% | ||
| 3 | VANGUARD GROUP INC | 3,409,186 | 15,682,000 | 7.25% | ||
| 4 | BlackRock Fund Advisors | 3,189,673 | 14,672,000 | 6.79% | ||
| 5 | Sarissa Capital Management LP | 2,725,000 | 12,535,000 | 5.80% | ||
| 6 | GOLDMAN SACHS GROUP INC | 2,654,765 | 12,212,000 | 5.65% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 2,483,293 | 11,423,000 | 5.28% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,225,194 | 10,236,000 | 4.73% | ||
| 9 | D. E. Shaw & Co., Inc. | 1,856,267 | 8,539,000 | 3.95% | ||
| 10 | STATE STREET CORP | 1,366,949 | 6,286,000 | 2.91% | ||
| 11 | GREAT POINT PARTNERS LLC | 1,346,344 | 6,193,000 | 2.86% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,268,035 | 5,833,000 | 2.70% | ||
| 13 | NORTHERN TRUST CORP | 959,288 | 4,413,000 | 2.04% | ||
| 14 | SV Health Investors, LLC | 888,132 | 4,085,000 | 1.89% | ||
| 15 | DEUTSCHE BANK AG\ | 691,661 | 3,181,000 | 1.47% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 572,946 | 2,636,000 | 1.22% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 573,082 | 2,636,000 | 1.22% | ||
| 18 | Jefferies Group LLC | 556,600 | 2,560,000 | 1.18% | Put | |
| 19 | TFS CAPITAL LLC | 459,546 | 2,114,000 | 0.98% | ||
| 20 | Bank of New York Mellon Corp | 443,554 | 2,040,000 | 0.94% | ||
| 21 | GROUP ONE TRADING LLC | 420,864 | 1,936,000 | 0.90% | ||
| 22 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 412,101 | 1,896,000 | 0.88% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 1,840,000 | 0.85% | ||
| 24 | MARSHALL WACE, LLP | 386,825 | 1,779,000 | 0.82% | ||
| 25 | Jefferies Group LLC | 385,495 | 1,773,000 | 0.82% | ||
| 26 | JPMORGAN CHASE & CO | 319,435 | 1,469,000 | 0.68% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 299,098 | 1,376,000 | 0.64% | ||
| 28 | BlackRock Investment Management, LLC | 288,637 | 1,328,000 | 0.61% | ||
| 29 | BLACKROCK ADVISORS LLC | 270,196 | 1,243,000 | 0.57% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 250,575 | 1,153,000 | 0.53% | ||
| 31 | GLOBEFLEX CAPITAL L P | 238,239 | 1,096,000 | 0.51% | ||
| 32 | PICTET ASSET MANAGEMENT LTD | 237,400 | 821,000 | 0.38% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 170,467 | 784,000 | 0.36% | ||
| 34 | HIGHLAND CAPITAL MANAGEMENT LP | 169,600 | 781,000 | 0.36% | ||
| 35 | JACOBS LEVY EQUITY MANAGEMENT, INC | 167,700 | 771,000 | 0.36% | ||
| 36 | TURNER INVESTMENTS LLC | 161,100 | 741,000 | 0.34% | ||
| 37 | PDT Partners, LLC | 158,900 | 731,000 | 0.34% | ||
| 38 | BALYASNY ASSET MANAGEMENT L.P. | 149,097 | 686,000 | 0.32% | ||
| 39 | UBS Group AG | 138,359 | 636,000 | 0.29% | ||
| 40 | VIRTUS ETF ADVISERS LLC | 126,869 | 584,000 | 0.27% | ||
| 41 | TEACHERS ADVISORS, LLC | 121,418 | 559,000 | 0.26% | ||
| 42 | Swiss National Bank | 125,400 | 557,000 | 0.26% | ||
| 43 | TUDOR INVESTMENT CORP ET AL | 119,056 | 548,000 | 0.25% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 109,460 | 504,000 | 0.23% | ||
| 45 | Parallax Volatility Advisers, L.P. | 108,975 | 501,000 | 0.23% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 106,800 | 491,000 | 0.23% | ||
| 47 | A.R.T. Advisors, LLC | 106,114 | 488,000 | 0.23% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 96,500 | 444,000 | 0.21% | Put | |
| 49 | GOLDMAN SACHS GROUP INC | 94,000 | 432,000 | 0.20% | Put | |
| 50 | GOLDMAN SACHS GROUP INC | 94,000 | 432,000 | 0.20% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
