| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 75,000,000 | 1,120,500,000 | 72.76% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,498,991 | 67,213,000 | 4.36% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 2,878,930 | 43,011,000 | 2.79% | ||
| 4 | Capital Research Global Investors | 2,834,574 | 42,349,000 | 2.75% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,200,672 | 32,878,000 | 2.13% | ||
| 6 | FRANKLIN RESOURCES INC | 1,612,682 | 24,093,000 | 1.56% | ||
| 7 | D. E. Shaw & Co., Inc. | 1,532,060 | 22,889,000 | 1.49% | ||
| 8 | BlackRock Finance, Inc. | 1,068,912 | 15,970,000 | 1.04% | ||
| 9 | IPL ADVISERS, LLC | 959,972 | 14,342,000 | 0.93% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 721,349 | 10,777,000 | 0.70% | ||
| 11 | FMR LLC | 677,170 | 10,117,000 | 0.66% | ||
| 12 | CITADEL ADVISORS LLC | 621,015 | 9,278,000 | 0.60% | ||
| 13 | PointState Capital LP | 576,400 | 8,611,000 | 0.56% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 568,005 | 8,486,000 | 0.55% | ||
| 15 | DLD ASSET MANAGEMENT, LP | 526,700 | 7,864,000 | 0.51% | Call | |
| 16 | JPMORGAN CHASE & CO | 489,024 | 7,306,000 | 0.47% | ||
| 17 | VHCP MANAGEMENT II, LLC | 429,590 | 6,418,000 | 0.42% | ||
| 18 | Avoro Capital Advisors LLC | 384,587 | 5,746,000 | 0.37% | ||
| 19 | PURA VIDA INVESTMENTS, LLC | 380,000 | 5,677,000 | 0.37% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 376,800 | 5,629,000 | 0.37% | Call | |
| 21 | STATE STREET CORP | 357,975 | 5,348,000 | 0.35% | ||
| 22 | Blackstone Inc. | 353,669 | 5,284,000 | 0.34% | ||
| 23 | PERCEPTIVE ADVISORS LLC | 310,000 | 4,631,000 | 0.30% | ||
| 24 | NORTHERN TRUST CORP | 270,351 | 4,039,000 | 0.26% | ||
| 25 | Artal Group S.A. | 250,000 | 3,735,000 | 0.24% | ||
| 26 | Point72 Asset Management, L.P. | 209,100 | 3,124,000 | 0.20% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,700 | 2,939,000 | 0.19% | Put | |
| 28 | AMERICAN FINANCIAL GROUP INC | 172,395 | 2,576,000 | 0.17% | ||
| 29 | Candriam S.C.A. | 160,000 | 2,391,000 | 0.16% | ||
| 30 | VANGUARD GROUP INC | 131,681 | 1,968,000 | 0.13% | ||
| 31 | GOLDMAN SACHS GROUP INC | 125,673 | 1,878,000 | 0.12% | ||
| 32 | C WorldWide Group Holding A/S | 109,600 | 1,637,000 | 0.11% | ||
| 33 | GOLDMAN SACHS GROUP INC | 100,000 | 1,494,000 | 0.10% | Put | |
| 34 | NEXTHERA CAPITAL LP | 100,000 | 1,494,000 | 0.10% | Call | |
| 35 | PERCEPTIVE ADVISORS LLC | 200,000 | 1,420,000 | 0.09% | Call | |
| 36 | ALPS ADVISORS INC | 85,309 | 1,269,000 | 0.08% | ||
| 37 | Nationwide Fund Advisors | 83,543 | 1,248,000 | 0.08% | ||
| 38 | Bank of New York Mellon Corp | 80,863 | 1,209,000 | 0.08% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,084 | 1,077,000 | 0.07% | ||
| 40 | MORGAN STANLEY | 71,379 | 1,067,000 | 0.07% | ||
| 41 | CITADEL ADVISORS LLC | 67,100 | 1,002,000 | 0.07% | Call | |
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 66,664 | 996,000 | 0.06% | ||
| 43 | AMERIPRISE FINANCIAL INC | 60,868 | 909,000 | 0.06% | ||
| 44 | GROUP ONE TRADING LLC | 51,267 | 766,000 | 0.05% | ||
| 45 | BARCLAYS PLC | 50,000 | 747,000 | 0.05% | Call | |
| 46 | BARCLAYS PLC | 50,000 | 747,000 | 0.05% | Put | |
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,149 | 719,000 | 0.05% | ||
| 48 | Swiss National Bank | 45,600 | 681,000 | 0.04% | ||
| 49 | STRS OHIO | 45,400 | 678,000 | 0.04% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 41,700 | 623,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
