| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 75,000,000 | 1,528,500,000 | 76.90% | ||
| 2 | Visium Asset Management, LP | 5,080,000 | 103,528,000 | 5.21% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | 101,900,000 | 5.13% | ||
| 4 | D. E. Shaw & Co., Inc. | 1,750,000 | 35,665,000 | 1.79% | ||
| 5 | FRANKLIN RESOURCES INC | 1,722,030 | 35,095,000 | 1.77% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 1,395,435 | 28,439,000 | 1.43% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,000,000 | 20,380,000 | 1.03% | ||
| 8 | Alpha Wave Global, LP | 1,000,000 | 20,380,000 | 1.03% | ||
| 9 | PFM Health Sciences, LP | 952,745 | 19,417,000 | 0.98% | ||
| 10 | Lamond Capital Partners LLC | 692,961 | 14,123,000 | 0.71% | ||
| 11 | PRIMECAP MANAGEMENT CO/CA/ | 500,000 | 10,190,000 | 0.51% | ||
| 12 | JPMORGAN CHASE & CO | 418,916 | 8,537,000 | 0.43% | ||
| 13 | Avoro Capital Advisors LLC | 340,000 | 6,929,000 | 0.35% | ||
| 14 | BLACKROCK ADVISORS LLC | 235,000 | 4,789,000 | 0.24% | ||
| 15 | OppenheimerFunds, Inc. | 214,600 | 4,373,000 | 0.22% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 190,000 | 3,872,000 | 0.19% | ||
| 17 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 187,248 | 3,816,114 | 0.19% | ||
| 18 | MORGAN STANLEY | 179,263 | 3,653,000 | 0.18% | ||
| 19 | ACUTA CAPITAL PARTNERS, LLC | 170,000 | 3,465,000 | 0.17% | ||
| 20 | Asset Management One Co., Ltd. | 167,798 | 3,349,000 | 0.17% | ||
| 21 | Redmile Group, LLC | 150,000 | 3,057,000 | 0.15% | ||
| 22 | BlackRock Group LTD | 142,600 | 2,906,000 | 0.15% | ||
| 23 | Ghost Tree Capital, LLC | 135,000 | 2,751,000 | 0.14% | ||
| 24 | Alyeska Investment Group, L.P. | 125,000 | 2,548,000 | 0.13% | ||
| 25 | LAZARD ASSET MANAGEMENT LLC | 104,000 | 2,119,000 | 0.11% | ||
| 26 | Laurion Capital Management LP | 90,000 | 1,834,000 | 0.09% | ||
| 27 | Atika Capital Management LLC | 75,000 | 1,528,000 | 0.08% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 74,574 | 1,520,000 | 0.08% | ||
| 29 | Foresite Capital Management II, LLC | 65,000 | 1,325,000 | 0.07% | ||
| 30 | TUDOR INVESTMENT CORP ET AL | 46,000 | 937,000 | 0.05% | ||
| 31 | BlackRock Finance, Inc. | 40,900 | 834,000 | 0.04% | ||
| 32 | MOORE CAPITAL MANAGEMENT, LP | 40,000 | 815,000 | 0.04% | ||
| 33 | CITADEL ADVISORS LLC | 33,869 | 691,000 | 0.03% | ||
| 34 | OMERS ADMINISTRATION Corp | 33,900 | 691,000 | 0.03% | ||
| 35 | Partner Investment Management, L.P. | 22,769 | 464,000 | 0.02% | ||
| 36 | HIGHLAND CAPITAL MANAGEMENT LP | 20,000 | 408,000 | 0.02% | ||
| 37 | Sterling Capital Management LLC | 20,000 | 408,000 | 0.02% | ||
| 38 | Hudson Bay Capital Management LP | 20,000 | 408,000 | 0.02% | ||
| 39 | Private Capital Advisors, Inc. | 17,000 | 346,000 | 0.02% | ||
| 40 | Pentwater Capital Management LP | 15,000 | 306,000 | 0.02% | ||
| 41 | BlackRock Investment Management, LLC | 15,000 | 306,000 | 0.02% | ||
| 42 | SG Americas Securities, LLC | 14,491 | 295,000 | 0.01% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,400 | 212,000 | 0.01% | Call | |
| 44 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,100 | 206,000 | 0.01% | ||
| 45 | ArrowMark Colorado Holdings LLC | 10,000 | 204,000 | 0.01% | ||
| 46 | NORGES BANK | 5,000 | 102,000 | 0.01% | ||
| 47 | MAZAMA CAPITAL MANAGEMENT INC | 2,509 | 51,000 | 0.00% | ||
| 48 | GILDER GAGNON HOWE & CO LLC | 1,000 | 20,000 | 0.00% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 500 | 10,190 | 0.00% | ||
| 50 | Tower Research Capital LLC (TRC) | 513 | 10,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
