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ISIS PHARMACEUTICALS INC DEL
ISIS PHARMACEUTICALS INC DEL. Institutional holdings reported to the SEC.

Institutional Holders (2016Q2)
Portfolio Summary: 46 Institutional holders with a total value of $321,210,980.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 ADVENT CAPITAL MANAGEMENT /DE/ 70,827,000 50,346,000 15.67% PRN
2 CITADEL ADVISORS LLC 51,500,000 36,662,000 11.41% PRN
3 SONORA INVESTMENT MANAGEMENT, LLC 29,330,000 20,706,980 6.45%
4 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 28,000,000 19,768,000 6.15% PRN
5 JPMORGAN CHASE & CO 27,523,000 19,370,000 6.03% PRN
6 HIGHBRIDGE CAPITAL MANAGEMENT LLC 26,000,000 18,503,000 5.76% PRN
7 Calamos Advisors LLC 17,500,000 12,373,000 3.85% PRN
8 LAZARD ASSET MANAGEMENT LLC 16,150,000 11,456,000 3.57% PRN
9 AMERIPRISE FINANCIAL INC 13,500,000 9,543,000 2.97% PRN
10 WELLS FARGO & COMPANY/MN 11,468,000 8,141,000 2.53% PRN
11 Invesco Ltd. 11,500,000 8,129,000 2.53% PRN
12 GUARDIAN LIFE INSURANCE CO OF AMERICA 11,500,000 8,129,000 2.53% PRN
13 MACKAY SHIELDS LLC 10,243,000 7,266,000 2.26% PRN
14 WOLVERINE ASSET MANAGEMENT LLC 10,000,000 7,135,000 2.22% PRN
15 BNP Paribas Asset Management Holding S.A. 10,000,000 7,129,000 2.22% PRN
16 STATE STREET CORP 9,465,000 6,745,000 2.10%
17 Jabre Capital Partners S.A. 8,200,000 5,875,000 1.83% PRN
18 ARISTEIA CAPITAL, L.L.C. 7,500,000 5,339,000 1.66% PRN
19 DEUTSCHE BANK AG\ 7,236,000 5,114,000 1.59% PRN
20 Verition Fund Management LLC 7,000,000 4,966,000 1.55% PRN
21 Man Investments (CH) AG 7,000,000 4,944,000 1.54% PRN
22 GLG Partners LP 6,500,000 4,589,000 1.43% PRN
23 ZAZOVE ASSOCIATES LLC 6,045,000 4,281,000 1.33% PRN
24 MORGAN STANLEY 5,839,000 4,145,000 1.29% PRN
25 UBS Group AG 5,280,000 3,732,000 1.16% PRN
26 Castle Creek Arbitrage, LLC 5,000,000 3,556,000 1.11% PRN
27 Clearbridge Investments, LLC 4,936,000 3,474,000 1.08% PRN
28 CSS LLC/IL 4,100,000 2,887,000 0.90% PRN
29 BARCLAYS PLC 4,026,000 2,846,000 0.89% PRN
30 SSI INVESTMENT MANAGEMENT LLC 3,950,000 2,792,000 0.87% PRN
31 BANK OF AMERICA CORP /DE/ 3,840,000 2,714,000 0.84% PRN
32 CREDIT AGRICOLE S A 2,113,000 1,494,000 0.47% PRN
33 CREDIT SUISSE AG/ 2,000,000 1,414,000 0.44% PRN
34 GOLDMAN SACHS GROUP INC 1,541,000 1,089,000 0.34% PRN
35 Mitsubishi UFJ Securities Holdings Co., Ltd. 1,336,000 954,000 0.30% PRN
36 Ionic Capital Management LLC 1,000,000 712,000 0.22% PRN
37 BlueCrest Capital Management Ltd 1,000,000 711,000 0.22% PRN
38 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 1,000,000 709,000 0.22% PRN
39 Jefferies Group LLC 975,000 692,000 0.22% PRN
40 Bank of New York Mellon Corp 450,000 317,000 0.10%
41 SOCIETE GENERALE 1,910 135,000 0.04% PRN
42 SG Americas Securities, LLC 1,910 135,000 0.04% PRN
43 SUNTRUST BANKS INC 168,000 118,000 0.04%
44 BlackRock Fund Advisors 100,000 71,000 0.02% PRN
45 MSI Financial Services Inc 4,000 3,000 0.00%
46 ROYAL BANK OF CANADA 2,000 1,000 0.00% PRN

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.