| 1 |
NEA Management Company, LLC |
3,220,728 |
65,252,000 |
32.99% |
|
|
| 2 |
Abingworth LLP |
2,601,814 |
52,036,000 |
26.31% |
|
|
| 3 |
CLOUGH CAPITAL PARTNERS L P |
838,791 |
16,676,000 |
8.43% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
744,380 |
15,007,000 |
7.59% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
729,333 |
14,389,000 |
7.28% |
|
|
| 6 |
New Leaf Venture Partners, L.L.C. |
586,475 |
11,882,000 |
6.01% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
372,191 |
7,541,000 |
3.81% |
|
|
| 8 |
Novo Holdings A/S |
223,317 |
4,524,000 |
2.29% |
|
|
| 9 |
LORD, ABBETT & CO. LLC |
211,700 |
4,289,000 |
2.17% |
|
|
| 10 |
VIVO CAPITAL, LLC |
148,878 |
3,016,000 |
1.52% |
|
|
| 11 |
JHL Capital Group LLC |
60,000 |
1,216,000 |
0.61% |
|
|
| 12 |
Laurion Capital Management LP |
26,000 |
527,000 |
0.27% |
|
|
| 13 |
BANK OF AMERICA CORP /DE/ |
21,500 |
436,000 |
0.22% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
18,350 |
371,000 |
0.19% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
11,913 |
241,000 |
0.12% |
|
|
| 16 |
MONASHEE INVESTMENT MANAGEMENT LLC |
7,186 |
146,000 |
0.07% |
|
|
| 17 |
UBS Group AG |
4,042 |
82,000 |
0.04% |
|
|
| 18 |
MORGAN STANLEY |
3,816 |
77,000 |
0.04% |
|
|
| 19 |
WELLS FARGO & COMPANY/MN |
980 |
20,000 |
0.01% |
|
|
| 20 |
SALEM INVESTMENT COUNSELORS INC |
650 |
13,000 |
0.01% |
|
|
| 21 |
LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA |
600 |
12,000 |
0.01% |
|
|
| 22 |
Tower Research Capital LLC (TRC) |
479 |
10,000 |
0.01% |
|
|
| 23 |
INTELLECTUS PARTNERS, LLC |
325 |
7,000 |
0.00% |
|
|
| 24 |
ELGETHUN CAPITAL MANAGEMENT |
300 |
6,000 |
0.00% |
|
|
| 25 |
CRIBSTONE CAPITAL MANAGEMENT, LLC |
90 |
2,000 |
0.00% |
|
|
| 26 |
TAYLOR WEALTH MANAGEMENT PARTNERS |
50 |
1,000 |
0.00% |
|
|
