| 1 |
QVT Financial LP |
37,231,342 |
437,096,000 |
75.79% |
|
|
| 2 |
BB BIOTECH AG |
3,302,835 |
38,775,000 |
6.72% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
2,348,422 |
27,570,000 |
4.78% |
|
|
| 4 |
BlackRock Finance, Inc. |
1,365,146 |
16,027,000 |
2.78% |
|
|
| 5 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
750,000 |
8,805,000 |
1.53% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
705,268 |
8,280,000 |
1.44% |
|
|
| 7 |
NORGES BANK |
621,719 |
7,299,000 |
1.27% |
|
|
| 8 |
GREAT POINT PARTNERS LLC |
407,559 |
4,785,000 |
0.83% |
|
|
| 9 |
Tekla Capital Management LLC |
400,000 |
4,696,000 |
0.81% |
|
|
| 10 |
VOYA INVESTMENT MANAGEMENT LLC |
399,919 |
4,695,000 |
0.81% |
|
|
| 11 |
D. E. Shaw & Co., Inc. |
350,000 |
4,109,000 |
0.71% |
|
|
| 12 |
EVENTIDE ASSET MANAGEMENT, LLC |
295,000 |
3,463,000 |
0.60% |
|
|
| 13 |
Rock Springs Capital Management LP |
150,000 |
1,761,000 |
0.31% |
|
|
| 14 |
STATE STREET CORP |
138,052 |
1,619,000 |
0.28% |
|
|
| 15 |
Cormorant Asset Management, LP |
100,000 |
1,174,000 |
0.20% |
|
|
| 16 |
NORTHERN TRUST CORP |
83,593 |
981,000 |
0.17% |
|
|
| 17 |
JPMORGAN CHASE & CO |
83,070 |
975,000 |
0.17% |
|
|
| 18 |
SCHONFELD STRATEGIC ADVISORS LLC |
70,000 |
822,000 |
0.14% |
|
|
| 19 |
ALPS ADVISORS INC |
51,839 |
600,000 |
0.10% |
|
|
| 20 |
VANGUARD GROUP INC |
29,958 |
352,000 |
0.06% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
26,543 |
312,000 |
0.05% |
|
|
| 22 |
OXFORD ASSET MANAGEMENT LLP |
25,774 |
303,000 |
0.05% |
|
|
| 23 |
Bank of New York Mellon Corp |
23,784 |
279,000 |
0.05% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
21,400 |
251,000 |
0.04% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
18,645 |
218,000 |
0.04% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
17,523 |
206,000 |
0.04% |
|
|
| 27 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
16,900 |
199,000 |
0.03% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
16,527 |
194,000 |
0.03% |
|
|
| 29 |
MORGAN STANLEY |
14,490 |
170,000 |
0.03% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
11,540 |
135,000 |
0.02% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
11,101 |
130,000 |
0.02% |
|
|
| 32 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,551 |
101,000 |
0.02% |
|
|
| 33 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,166 |
72,000 |
0.01% |
|
|
| 34 |
ACADIAN ASSET MANAGEMENT LLC |
4,156 |
49,000 |
0.01% |
|
|
| 35 |
Nationwide Fund Advisors |
3,722 |
44,000 |
0.01% |
|
|
| 36 |
STRS OHIO |
3,400 |
39,000 |
0.01% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
2,657 |
30,000 |
0.01% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
1,882 |
22,000 |
0.00% |
|
|
| 39 |
PNC FINANCIAL SERVICES GROUP, INC. |
1,750 |
21,000 |
0.00% |
|
|
| 40 |
UBS Group AG |
1,743 |
20,000 |
0.00% |
|
|
| 41 |
Legal & General Group Plc |
1,626 |
19,000 |
0.00% |
|
|
| 42 |
Ameritas Investment Partners, Inc. |
902 |
11,000 |
0.00% |
|
|
| 43 |
MEEDER ASSET MANAGEMENT INC |
306 |
4,000 |
0.00% |
|
|
| 44 |
Tower Research Capital LLC (TRC) |
320 |
4,000 |
0.00% |
|
|
| 45 |
ROYAL BANK OF CANADA |
230 |
3,000 |
0.00% |
|
|
| 46 |
CITIGROUP INC |
111 |
1,000 |
0.00% |
|
|
| 47 |
BARCLAYS PLC |
143 |
1,000 |
0.00% |
|
|
| 48 |
BNP PARIBAS FINANCIAL MARKETS |
46 |
540 |
0.00% |
|
|
