| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEUTSCHE BANK AG\ | 5 | 0 | 0.00% | ||
| 2 | ROYAL BANK OF CANADA | 1 | 0 | 0.00% | ||
| 3 | MORGAN STANLEY | 200 | 1,000 | 0.00% | ||
| 4 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 310 | 3,000 | 0.01% | ||
| 5 | Tower Research Capital LLC (TRC) | 705 | 6,000 | 0.01% | ||
| 6 | UBS Group AG | 2,307 | 18,000 | 0.03% | ||
| 7 | BlackRock Finance, Inc. | 3,418 | 27,000 | 0.05% | ||
| 8 | FIRST QUADRANT LLC/CA | 10,850 | 85,000 | 0.14% | ||
| 9 | A.R.T. Advisors, LLC | 11,116 | 86,000 | 0.15% | ||
| 10 | Alyeska Investment Group, L.P. | 11,316 | 88,000 | 0.15% | ||
| 11 | BOOTHBAY FUND MANAGEMENT, LLC | 21,665 | 169,000 | 0.29% | ||
| 12 | EVENTIDE ASSET MANAGEMENT, LLC | 98,100 | 766,000 | 1.29% | ||
| 13 | VANGUARD GROUP INC | 180,772 | 1,412,000 | 2.39% | ||
| 14 | VHCP MANAGEMENT II, LLC | 221,651 | 1,635,000 | 2.76% | ||
| 15 | VIVO CAPITAL, LLC | 300,325 | 2,346,000 | 3.97% | ||
| 16 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 322,436 | 2,518,000 | 4.26% | ||
| 17 | INTERWEST VENTURE MANAGEMENT CO | 329,942 | 2,577,000 | 4.36% | ||
| 18 | RA CAPITAL MANAGEMENT, L.P. | 591,070 | 4,616,000 | 7.80% | ||
| 19 | SV Health Investors, LLC | 2,579,490 | 20,146,000 | 34.05% | ||
| 20 | Novo Holdings A/S | 2,901,927 | 22,664,000 | 38.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
