| 1 |
BVF INC/IL |
8,596,357 |
28,454,000 |
46.46% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
5,000,000 |
16,550,000 |
27.02% |
|
|
| 3 |
STONEPINE CAPITAL MANAGEMENT, LLC |
2,284,381 |
7,561,000 |
12.35% |
|
|
| 4 |
VANGUARD GROUP INC |
753,379 |
2,494,000 |
4.07% |
|
|
| 5 |
Alyeska Investment Group, L.P. |
466,529 |
1,544,000 |
2.52% |
|
|
| 6 |
BlackRock Finance, Inc. |
386,769 |
1,281,000 |
2.09% |
|
|
| 7 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
250,636 |
830,000 |
1.36% |
|
|
| 8 |
RENAISSANCE TECHNOLOGIES LLC |
136,745 |
453,000 |
0.74% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
113,682 |
376,000 |
0.61% |
|
|
| 10 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
82,600 |
273,000 |
0.45% |
Call |
|
| 11 |
TIEDEMANN ADVISORS, LLC |
73,129 |
242,000 |
0.40% |
|
|
| 12 |
BLAIR WILLIAM & CO/IL |
51,198 |
169,000 |
0.28% |
|
|
| 13 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
52,621 |
157,000 |
0.26% |
|
|
| 14 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
43,720 |
145,000 |
0.24% |
|
|
| 15 |
NORTHERN TRUST CORP |
38,725 |
128,000 |
0.21% |
|
|
| 16 |
MORGAN STANLEY |
38,179 |
127,000 |
0.21% |
|
|
| 17 |
WASHINGTON TRUST Co |
31,400 |
104,000 |
0.17% |
|
|
| 18 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
28,400 |
94,000 |
0.15% |
|
|
| 19 |
GOLDMAN SACHS GROUP INC |
23,412 |
77,000 |
0.13% |
|
|
| 20 |
Bank of New York Mellon Corp |
21,643 |
72,000 |
0.12% |
|
|
| 21 |
Virtu KCG Holdings LLC |
13,015 |
43,000 |
0.07% |
|
|
| 22 |
STATE STREET CORP |
11,051 |
37,000 |
0.06% |
|
|
| 23 |
UBS Group AG |
4,338 |
14,000 |
0.02% |
|
|
| 24 |
Creative Planning |
2,573 |
9,000 |
0.01% |
|
|
| 25 |
Compagnie Lombard Odier SCmA |
800 |
3,000 |
0.00% |
|
|
| 26 |
BARCLAYS PLC |
522 |
2,000 |
0.00% |
|
|
| 27 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
731 |
2,000 |
0.00% |
|
|
| 28 |
SIMPLEX TRADING, LLC |
745 |
2,000 |
0.00% |
|
|
| 29 |
ADVISOR GROUP, INC. |
556 |
2,000 |
0.00% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
227 |
1,000 |
0.00% |
|
|
| 31 |
MassMutual Private Wealth & Trust, FSB |
20 |
66 |
0.00% |
|
|
| 32 |
Live Your Vision, LLC |
6 |
0 |
0.00% |
|
|
| 33 |
IFP ADVISORS, INC |
116 |
0 |
0.00% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
140 |
0 |
0.00% |
|
|
| 35 |
CITIGROUP INC |
126 |
0 |
0.00% |
|
|
| 36 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
120 |
0 |
0.00% |
|
|
| 37 |
Advisory Services Network, LLC |
2 |
0 |
0.00% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
23 |
0 |
0.00% |
|
|
| 39 |
Financial Architects, Inc |
10 |
0 |
0.00% |
|
|
| 40 |
FIRST MANHATTAN CO. LLC. |
36 |
0 |
0.00% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
290 |
0 |
0.00% |
|
|
