| 1 |
FMR LLC |
4,046,316 |
82,387,000 |
30.53% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,583,185 |
34,814,000 |
12.90% |
|
|
| 3 |
Redmile Group, LLC |
1,114,160 |
22,523,000 |
8.35% |
|
|
| 4 |
PHARMSTANDARD INTERNATIONAL S.A. |
662,063 |
14,559,000 |
5.39% |
|
|
| 5 |
Omega Fund Management, LLC |
579,650 |
12,747,000 |
4.72% |
|
|
| 6 |
PFM Health Sciences, LP |
498,714 |
10,967,000 |
4.06% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
468,867 |
10,310,000 |
3.82% |
|
|
| 8 |
Cormorant Asset Management, LP |
434,976 |
9,565,000 |
3.54% |
|
|
| 9 |
Artal Group S.A. |
300,000 |
6,597,000 |
2.44% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
293,862 |
6,462,000 |
2.39% |
|
|
| 11 |
BROWN ADVISORY INC |
287,105 |
6,314,000 |
2.34% |
|
|
| 12 |
BlackRock Finance, Inc. |
263,090 |
5,786,000 |
2.14% |
|
|
| 13 |
EcoR1 Capital, LLC |
258,457 |
5,683,000 |
2.11% |
|
|
| 14 |
HILLHOUSE INVESTMENT MANAGEMENT, LTD. |
170,300 |
3,745,000 |
1.39% |
|
|
| 15 |
AMERIPRISE FINANCIAL INC |
161,474 |
3,550,000 |
1.32% |
|
|
| 16 |
Alyeska Investment Group, L.P. |
137,556 |
3,025,000 |
1.12% |
|
|
| 17 |
CASDIN CAPITAL, LLC |
130,000 |
2,859,000 |
1.06% |
|
|
| 18 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
125,560 |
2,761,064 |
1.02% |
|
|
| 19 |
Foresite Capital Management II, LLC |
119,912 |
2,637,000 |
0.98% |
|
|
| 20 |
VANGUARD GROUP INC |
113,964 |
2,506,000 |
0.93% |
|
|
| 21 |
JPMORGAN CHASE & CO |
107,078 |
2,354,000 |
0.87% |
|
|
| 22 |
BAKER BROS. ADVISORS LP |
100,000 |
2,199,000 |
0.81% |
|
|
| 23 |
TUDOR INVESTMENT CORP ET AL |
100,000 |
2,199,000 |
0.81% |
|
|
| 24 |
FORESITE CAPITAL MANAGEMENT III, LLC |
91,600 |
2,014,000 |
0.75% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
71,568 |
1,573,000 |
0.58% |
|
|
| 26 |
Spark Investment Management LLC |
61,200 |
1,345,000 |
0.50% |
|
|
| 27 |
STATE STREET CORP |
45,430 |
1,000,000 |
0.37% |
|
|
| 28 |
Laurion Capital Management LP |
40,000 |
880,000 |
0.33% |
|
|
| 29 |
AMERICAN CENTURY COMPANIES INC |
34,886 |
767,000 |
0.28% |
|
|
| 30 |
NORTHERN TRUST CORP |
33,292 |
732,000 |
0.27% |
|
|
| 31 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
30,488 |
670,000 |
0.25% |
|
|
| 32 |
D. E. Shaw & Co., Inc. |
20,240 |
445,000 |
0.16% |
|
|
| 33 |
MONASHEE INVESTMENT MANAGEMENT LLC |
17,773 |
391,000 |
0.14% |
|
PRN |
| 34 |
Bank of New York Mellon Corp |
17,511 |
385,000 |
0.14% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,700 |
279,000 |
0.10% |
|
|
| 36 |
MORGAN STANLEY |
12,609 |
278,000 |
0.10% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
12,386 |
273,000 |
0.10% |
|
|
| 38 |
GOLDMAN SACHS GROUP INC |
12,312 |
271,000 |
0.10% |
|
|
| 39 |
HSBC HOLDINGS PLC |
11,620 |
256,000 |
0.09% |
|
|
| 40 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,413 |
229,000 |
0.08% |
|
|
| 41 |
Paloma Partners Management Co |
9,612 |
212,000 |
0.08% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
8,884 |
195,000 |
0.07% |
|
|
| 43 |
DEUTSCHE BANK AG\ |
8,096 |
177,000 |
0.07% |
|
|
| 44 |
PANAGORA ASSET MANAGEMENT INC |
6,413 |
141,000 |
0.05% |
|
|
| 45 |
CITIGROUP INC |
6,364 |
140,000 |
0.05% |
|
|
| 46 |
Partner Investment Management, L.P. |
5,484 |
121,000 |
0.04% |
|
|
| 47 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
4,500 |
99,000 |
0.04% |
|
|
| 48 |
Nationwide Fund Advisors |
3,939 |
87,000 |
0.03% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
3,640 |
80,000 |
0.03% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
3,357 |
74,000 |
0.03% |
|
|
