| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,814,847 | 18,254,000 | 22.32% | ||
| 2 | BlackRock Finance, Inc. | 1,121,085 | 11,759,000 | 14.38% | ||
| 3 | JENNISON ASSOCIATES LLC | 650,074 | 6,739,000 | 8.24% | ||
| 4 | Tekla Capital Management LLC | 535,824 | 5,229,000 | 6.39% | ||
| 5 | OppenheimerFunds, Inc. | 425,000 | 4,458,000 | 5.45% | ||
| 6 | Redmile Group, LLC | 448,781 | 4,237,000 | 5.18% | ||
| 7 | AMERIPRISE FINANCIAL INC | 358,468 | 3,761,000 | 4.60% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 361,640 | 3,637,000 | 4.45% | ||
| 9 | BAKER BROS. ADVISORS LP | 333,333 | 3,497,000 | 4.28% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 305,674 | 3,042,000 | 3.72% | ||
| 11 | Cormorant Asset Management, LP | 223,972 | 2,349,000 | 2.87% | SH | |
| 12 | CASDIN CAPITAL, LLC | 221,700 | 2,326,000 | 2.84% | ||
| 13 | DRIEHAUS CAPITAL MANAGEMENT LLC | 217,841 | 2,285,000 | 2.79% | ||
| 14 | DEUTSCHE BANK AG\ | 205,826 | 2,157,000 | 2.64% | ||
| 15 | VICTORY CAPITAL MANAGEMENT INC | 131,000 | 1,374,000 | 1.68% | ||
| 16 | VANGUARD GROUP INC | 99,317 | 1,042,000 | 1.27% | ||
| 17 | GOLDMAN SACHS GROUP INC | 87,943 | 923,000 | 1.13% | ||
| 18 | NORTHERN TRUST CORP | 57,547 | 604,000 | 0.74% | ||
| 19 | STATE STREET CORP | 49,600 | 520,000 | 0.64% | ||
| 20 | SCHONFELD STRATEGIC ADVISORS LLC | 35,000 | 367,000 | 0.45% | ||
| 21 | Lombard Odier Asset Management (USA) Corp | 31,250 | 328,000 | 0.40% | ||
| 22 | NEXTHERA CAPITAL LP | 30,543 | 320,000 | 0.39% | ||
| 23 | CITIGROUP INC | 28,629 | 301,000 | 0.37% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 27,842 | 292,000 | 0.36% | ||
| 25 | ALPS ADVISORS INC | 22,206 | 233,000 | 0.28% | ||
| 26 | Laurion Capital Management LP | 20,000 | 210,000 | 0.26% | ||
| 27 | CITADEL ADVISORS LLC | 19,493 | 204,000 | 0.25% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 18,443 | 193,000 | 0.24% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 17,993 | 189,000 | 0.23% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,500 | 153,000 | 0.19% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 13,561 | 142,000 | 0.17% | ||
| 32 | Bank of New York Mellon Corp | 12,870 | 135,000 | 0.17% | ||
| 33 | NORGES BANK | 12,155 | 128,000 | 0.16% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,900 | 93,000 | 0.11% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 7,900 | 83,000 | 0.10% | ||
| 36 | TEACHERS ADVISORS, LLC | 6,063 | 64,000 | 0.08% | ||
| 37 | MORGAN STANLEY | 5,057 | 53,000 | 0.06% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 3,132 | 33,000 | 0.04% | ||
| 39 | Nationwide Fund Advisors | 2,879 | 30,000 | 0.04% | ||
| 40 | STRS OHIO | 1,500 | 15,000 | 0.02% | ||
| 41 | Legal & General Group Plc | 1,098 | 11,000 | 0.01% | ||
| 42 | BNP PARIBAS FINANCIAL MARKETS | 530 | 5,560 | 0.01% | ||
| 43 | Ameritas Investment Partners, Inc. | 443 | 5,000 | 0.01% | ||
| 44 | Tower Research Capital LLC (TRC) | 0 | 0 | 0.00% | ||
| 45 | ROYAL BANK OF CANADA | 6 | 0 | 0.00% | ||
| 46 | BARCLAYS PLC | 4 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
