| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 8,142,000 | 166,015,000 | 13.37% | ||
| 2 | FMR LLC | 4,178,232 | 87,827,000 | 7.07% | ||
| 3 | Invesco Ltd. | 3,924,684 | 82,497,000 | 6.64% | ||
| 4 | VANGUARD GROUP INC | 3,390,593 | 71,270,000 | 5.74% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,735,842 | 57,507,000 | 4.63% | ||
| 6 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 2,486,149 | 52,259,000 | 4.21% | ||
| 7 | WESTFIELD CAPITAL MANAGEMENT CO LP | 2,402,633 | 50,503,000 | 4.07% | ||
| 8 | Fisher Asset Management, LLC | 2,283,400 | 47,997,000 | 3.87% | ||
| 9 | BRIDGER MANAGEMENT, LLC | 2,083,679 | 43,799,000 | 3.53% | ||
| 10 | Palo Alto Investors LP | 2,056,251 | 43,222,000 | 3.48% | ||
| 11 | BlackRock Fund Advisors | 1,336,493 | 28,093,000 | 2.26% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,277,622 | 26,856,000 | 2.16% | ||
| 13 | GW&K Investment Management, LLC | 1,236,458 | 25,990,000 | 2.09% | ||
| 14 | DEUTSCHE BANK AG\ | 1,117,554 | 23,489,000 | 1.89% | ||
| 15 | Epoch Investment Partners, Inc. | 1,114,718 | 23,431,000 | 1.89% | ||
| 16 | CITADEL ADVISORS LLC | 1,011,999 | 21,272,000 | 1.71% | ||
| 17 | STATE STREET CORP | 863,899 | 18,159,000 | 1.46% | ||
| 18 | Foundation Asset Management, LP | 855,330 | 17,979,000 | 1.45% | ||
| 19 | Capital World Investors | 853,485 | 17,940,000 | 1.44% | ||
| 20 | Pine River Capital Management L.P. | 846,550 | 17,794,000 | 1.43% | ||
| 21 | JPMORGAN CHASE & CO | 737,284 | 15,498,000 | 1.25% | ||
| 22 | Elk Creek Partners, LLC | 646,387 | 13,587,000 | 1.09% | ||
| 23 | TWO SIGMA ADVISERS, LP | 600,217 | 12,805,000 | 1.03% | ||
| 24 | NORTHERN TRUST CORP | 608,624 | 12,794,000 | 1.03% | ||
| 25 | FEDERATED HERMES, INC. | 599,312 | 12,597,000 | 1.01% | ||
| 26 | BLUE JAY CAPITAL MANAGEMENT, LLC | 565,000 | 11,876,000 | 0.96% | ||
| 27 | DIMENSIONAL FUND ADVISORS LP | 547,272 | 11,504,000 | 0.93% | ||
| 28 | GABELLI FUNDS LLC | 542,992 | 11,414,000 | 0.92% | ||
| 29 | BARCLAYS PLC | 520,106 | 10,923,000 | 0.88% | ||
| 30 | TWO SIGMA INVESTMENTS, LP | 511,614 | 10,754,000 | 0.87% | ||
| 31 | Clearbridge Investments, LLC | 501,146 | 10,534,000 | 0.85% | ||
| 32 | SEGALL BRYANT & HAMILL, LLC | 474,590 | 9,976,000 | 0.80% | ||
| 33 | MORGAN STANLEY | 457,062 | 9,607,000 | 0.77% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 410,776 | 8,635,000 | 0.70% | ||
| 35 | D. E. Shaw & Co., Inc. | 400,947 | 8,428,000 | 0.68% | ||
| 36 | WELLS FARGO & COMPANY/MN | 394,227 | 8,287,000 | 0.67% | ||
| 37 | Alberta Investment Management Corp | 385,170 | 8,096,000 | 0.65% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 338,443 | 7,114,000 | 0.57% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 337,827 | 7,101,000 | 0.57% | ||
| 40 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 316,379 | 6,650,000 | 0.54% | ||
| 41 | Neuberger Berman Group LLC | 287,010 | 6,033,000 | 0.49% | ||
| 42 | Retirement Systems of Alabama | 259,000 | 5,444,000 | 0.44% | ||
| 43 | Bank of New York Mellon Corp | 244,976 | 5,150,000 | 0.41% | ||
| 44 | GAMCO INVESTORS, INC. ET AL | 211,000 | 4,435,000 | 0.36% | ||
| 45 | PURA VIDA INVESTMENTS, LLC | 210,101 | 4,416,000 | 0.36% | ||
| 46 | ROYAL BANK OF CANADA | 203,115 | 4,270,000 | 0.34% | ||
| 47 | STATE OF WISCONSIN INVESTMENT BOARD | 200,000 | 4,204,000 | 0.34% | ||
| 48 | AXA S.A. | 196,672 | 4,134,000 | 0.33% | ||
| 49 | Pentwater Capital Management LP | 190,044 | 3,875,000 | 0.31% | ||
| 50 | BlackRock Investment Management, LLC | 182,662 | 3,840,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
