| 1 |
Consonance Capital Management LP |
2,352,940 |
6,706,000 |
25.76% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
2,170,000 |
6,185,000 |
23.76% |
|
|
| 3 |
PERCEPTIVE ADVISORS LLC |
1,100,000 |
3,135,000 |
12.04% |
|
|
| 4 |
SABBY MANAGEMENT, LLC |
876,173 |
2,497,000 |
9.59% |
|
|
| 5 |
BlackRock Institutional Trust Company, N.A. |
558,600 |
1,592,000 |
6.12% |
|
|
| 6 |
VANGUARD GROUP INC |
397,757 |
1,133,000 |
4.35% |
|
|
| 7 |
FRED ALGER MANAGEMENT, LLC |
392,000 |
1,117,000 |
4.29% |
|
|
| 8 |
PERKINS CAPITAL MANAGEMENT INC |
352,000 |
1,003,000 |
3.85% |
|
|
| 9 |
KENNEDY CAPITAL MANAGEMENT LLC |
300,000 |
855,000 |
3.28% |
|
|
| 10 |
DAFNA Capital Management LLC |
238,900 |
681,000 |
2.62% |
|
SH |
| 11 |
Visium Asset Management, LP |
238,416 |
679,000 |
2.61% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
44,366 |
126,000 |
0.48% |
|
|
| 13 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
43,900 |
125,000 |
0.48% |
|
|
| 14 |
JANE STREET GROUP, LLC |
24,945 |
71,000 |
0.27% |
|
|
| 15 |
NORTHERN TRUST CORP |
22,788 |
65,000 |
0.25% |
|
|
| 16 |
HighTower Advisors, LLC |
13,014 |
37,000 |
0.14% |
|
|
| 17 |
BlackRock Investment Management, LLC |
3,798 |
11,000 |
0.04% |
|
|
| 18 |
UBS AG |
1,373 |
4,000 |
0.02% |
|
|
| 19 |
MORGAN STANLEY |
948 |
3,000 |
0.01% |
|
|
| 20 |
BARCLAYS PLC |
1,250 |
3,000 |
0.01% |
|
|
| 21 |
BANK OF AMERICA CORP /DE/ |
753 |
2,000 |
0.01% |
|
|
| 22 |
AMERICAN INTERNATIONAL GROUP, INC. |
598 |
1,705 |
0.01% |
|
|
| 23 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
181 |
1,000 |
0.00% |
|
|
| 24 |
Plante Moran Financial Advisors, LLC |
13 |
0 |
0.00% |
|
|
| 25 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
19 |
0 |
0.00% |
|
|
| 26 |
WFG Advisors, LP |
1 |
0 |
0.00% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
28 |
0 |
0.00% |
|
|
| 28 |
Creative Planning |
56 |
0 |
0.00% |
|
|
| 29 |
ROYAL BANK OF CANADA |
6 |
0 |
0.00% |
|
|
| 30 |
CITIGROUP INC |
46 |
0 |
0.00% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
1 |
0 |
0.00% |
|
|
