| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 1,625,120 | 50,639,000 | 7.73% | ||
| 2 | NEXT CENTURY GROWTH INVESTORS LLC | 1,547,289 | 48,213,000 | 7.36% | ||
| 3 | WADDELL & REED FINANCIAL INC | 1,364,700 | 42,524,000 | 6.49% | ||
| 4 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,149,296 | 35,812,000 | 5.47% | ||
| 5 | FMR LLC | 1,076,936 | 33,557,000 | 5.12% | ||
| 6 | WELLS FARGO & COMPANY/MN | 869,511 | 27,093,000 | 4.14% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 849,640 | 26,475,000 | 4.04% | ||
| 8 | VANGUARD GROUP INC | 836,264 | 26,057,000 | 3.98% | ||
| 9 | BlackRock Fund Advisors | 781,080 | 24,338,000 | 3.71% | ||
| 10 | JENNISON ASSOCIATES LLC | 631,329 | 19,672,000 | 3.00% | ||
| 11 | COLUMBUS CIRCLE INVESTORS | 624,990 | 19,475,000 | 2.97% | ||
| 12 | LOOMIS SAYLES & CO L P | 551,037 | 17,170,000 | 2.62% | ||
| 13 | Redmile Group, LLC | 493,345 | 15,373,000 | 2.35% | ||
| 14 | OppenheimerFunds, Inc. | 480,810 | 14,982,000 | 2.29% | ||
| 15 | IRONWOOD INVESTMENT MANAGEMENT LLC | 468,976 | 14,613,000 | 2.23% | ||
| 16 | STATE STREET CORP | 446,248 | 13,907,000 | 2.12% | ||
| 17 | WALL STREET ASSOCIATES | 368,100 | 11,470,000 | 1.75% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 337,517 | 10,517,000 | 1.61% | ||
| 19 | NORTHERN TRUST CORP | 329,985 | 10,282,000 | 1.57% | ||
| 20 | Point72 Asset Management, L.P. | 315,487 | 9,831,000 | 1.50% | ||
| 21 | OBERWEIS ASSET MANAGEMENT INC/ | 290,186 | 9,042,000 | 1.38% | ||
| 22 | WASATCH ADVISORS LP | 260,754 | 8,125,000 | 1.24% | ||
| 23 | NORTHPOINTE CAPITAL LLC | 224,199 | 6,986,000 | 1.07% | ||
| 24 | Allianz Asset Management GmbH | 222,110 | 6,921,000 | 1.06% | ||
| 25 | Granahan Investment Management, LLC | 210,090 | 6,546,000 | 1.00% | ||
| 26 | CASTLEARK MANAGEMENT LLC | 208,004 | 6,481,000 | 0.99% | ||
| 27 | ORBIMED ADVISORS LLC | 206,000 | 6,419,000 | 0.98% | ||
| 28 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 203,893 | 6,353,000 | 0.97% | ||
| 29 | RUSSELL FRANK CO/ | 220,973 | 5,999,000 | 0.92% | ||
| 30 | ESSEX INVESTMENT MANAGEMENT CO LLC | 192,387 | 5,995,000 | 0.92% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 181,903 | 5,668,000 | 0.87% | ||
| 32 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 168,900 | 5,263,000 | 0.80% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 165,212 | 5,148,000 | 0.79% | ||
| 34 | LORD, ABBETT & CO. LLC | 155,381 | 4,842,000 | 0.74% | ||
| 35 | Bank of New York Mellon Corp | 155,409 | 4,842,000 | 0.74% | ||
| 36 | Opaleye Management Inc. | 135,000 | 4,207,000 | 0.64% | ||
| 37 | PERKINS CAPITAL MANAGEMENT INC | 130,050 | 4,052,000 | 0.62% | ||
| 38 | AMERIPRISE FINANCIAL INC | 127,902 | 3,985,000 | 0.61% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,425 | 3,784,000 | 0.58% | ||
| 40 | HealthCor Management, L.P. | 104,400 | 3,253,000 | 0.50% | ||
| 41 | TURNER INVESTMENTS LLC | 100,000 | 3,116,000 | 0.48% | ||
| 42 | DENVER INVESTMENT ADVISORS LLC | 98,332 | 3,064,000 | 0.47% | ||
| 43 | SOPHROSYNE CAPITAL LLC | 92,941 | 2,898,000 | 0.44% | ||
| 44 | Apex Capital Management | 90,629 | 2,824,000 | 0.43% | ||
| 45 | Teton Advisors, Inc. | 89,100 | 2,776,000 | 0.42% | ||
| 46 | WFG Advisors, LP | 87,520 | 2,727,000 | 0.42% | ||
| 47 | Timpani Capital Management LLC | 81,679 | 2,545,000 | 0.39% | ||
| 48 | BlackRock Investment Management, LLC | 79,966 | 2,492,000 | 0.38% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 69,270 | 2,159,000 | 0.33% | ||
| 50 | AQR CAPITAL MANAGEMENT LLC | 59,711 | 1,861,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
