| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Consonance Capital Management LP | 1,943,054 | 45,914,000 | 8.84% | ||
| 2 | NEXT CENTURY GROWTH INVESTORS LLC | 1,491,370 | 35,241,000 | 6.78% | ||
| 3 | WADDELL & REED FINANCIAL INC | 1,367,800 | 32,321,000 | 6.22% | ||
| 4 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,123,992 | 26,560,000 | 5.11% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 1,067,668 | 25,229,000 | 4.86% | ||
| 6 | WELLS FARGO & COMPANY/MN | 894,048 | 21,125,000 | 4.07% | ||
| 7 | VANGUARD GROUP INC | 858,279 | 20,282,000 | 3.90% | ||
| 8 | BlackRock Fund Advisors | 751,934 | 17,768,000 | 3.42% | ||
| 9 | FMR LLC | 696,962 | 16,469,000 | 3.17% | ||
| 10 | COLUMBUS CIRCLE INVESTORS | 694,762 | 16,417,000 | 3.16% | ||
| 11 | JENNISON ASSOCIATES LLC | 675,670 | 15,966,000 | 3.07% | ||
| 12 | OppenheimerFunds, Inc. | 552,680 | 13,060,000 | 2.51% | ||
| 13 | Granahan Investment Management, LLC | 539,800 | 12,755,000 | 2.46% | ||
| 14 | LOOMIS SAYLES & CO L P | 536,836 | 12,686,000 | 2.44% | ||
| 15 | Point72 Asset Management, L.P. | 464,800 | 10,983,000 | 2.11% | ||
| 16 | STATE STREET CORP | 438,894 | 10,368,000 | 2.00% | ||
| 17 | IRONWOOD INVESTMENT MANAGEMENT LLC | 432,355 | 10,217,000 | 1.97% | ||
| 18 | Redmile Group, LLC | 370,208 | 8,748,000 | 1.68% | ||
| 19 | CASTLEARK MANAGEMENT LLC | 259,270 | 8,242,000 | 1.59% | ||
| 20 | WALL STREET ASSOCIATES | 347,800 | 8,219,000 | 1.58% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 326,463 | 7,714,000 | 1.49% | ||
| 22 | NORTHERN TRUST CORP | 322,781 | 7,628,000 | 1.47% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 320,088 | 7,564,000 | 1.46% | ||
| 24 | OBERWEIS ASSET MANAGEMENT INC/ | 265,586 | 6,276,000 | 1.21% | ||
| 25 | WASATCH ADVISORS LP | 258,541 | 6,109,000 | 1.18% | ||
| 26 | LORD, ABBETT & CO. LLC | 208,319 | 4,923,000 | 0.95% | ||
| 27 | Allianz Asset Management GmbH | 206,587 | 4,882,000 | 0.94% | ||
| 28 | NORTHPOINTE CAPITAL LLC | 204,399 | 4,830,000 | 0.93% | ||
| 29 | RUSSELL FRANK CO/ | 203,556 | 4,810,000 | 0.93% | ||
| 30 | ESSEX INVESTMENT MANAGEMENT CO LLC | 186,675 | 4,411,000 | 0.85% | ||
| 31 | ORBIMED ADVISORS LLC | 170,000 | 4,017,000 | 0.77% | ||
| 32 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 168,900 | 3,991,000 | 0.77% | ||
| 33 | HealthCor Management, L.P. | 167,900 | 3,967,000 | 0.76% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 167,599 | 3,960,000 | 0.76% | ||
| 35 | Bank of New York Mellon Corp | 141,699 | 3,349,000 | 0.64% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 136,800 | 3,233,000 | 0.62% | ||
| 37 | Numeric Investors LLC | 126,824 | 2,997,000 | 0.58% | ||
| 38 | Opaleye Management Inc. | 125,000 | 2,953,750 | 0.57% | ||
| 39 | MAIRS & POWER INC | 111,842 | 2,643,000 | 0.51% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 103,564 | 2,447,000 | 0.47% | ||
| 41 | PERKINS CAPITAL MANAGEMENT INC | 102,700 | 2,427,000 | 0.47% | ||
| 42 | Apex Capital Management | 100,525 | 2,375,000 | 0.46% | ||
| 43 | SIT INVESTMENT ASSOCIATES INC | 100,065 | 2,365,000 | 0.46% | ||
| 44 | DENVER INVESTMENT ADVISORS LLC | 97,335 | 2,300,000 | 0.44% | ||
| 45 | TURNER INVESTMENTS LLC | 95,370 | 2,254,000 | 0.43% | ||
| 46 | SOPHROSYNE CAPITAL LLC | 91,841 | 2,170,000 | 0.42% | ||
| 47 | NICHOLAS COMPANY, INC. | 90,990 | 2,150,000 | 0.41% | ||
| 48 | Teton Advisors, Inc. | 89,100 | 2,105,000 | 0.41% | ||
| 49 | Timpani Capital Management LLC | 85,240 | 2,014,000 | 0.39% | ||
| 50 | AMERIPRISE FINANCIAL INC | 84,619 | 2,000,000 | 0.39% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
