| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,760,394 | 37,317,000 | 16.97% | ||
| 2 | STATE STREET CORP | 4,174,872 | 23,047,000 | 10.48% | ||
| 3 | GREEN HOLDINGS LTD | 2,795,000 | 15,428,000 | 7.01% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 2,793,628 | 15,421,000 | 7.01% | ||
| 5 | VANGUARD GROUP INC | 2,559,190 | 14,127,000 | 6.42% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,529,982 | 13,966,000 | 6.35% | ||
| 7 | BlackRock Fund Advisors | 2,187,418 | 12,075,000 | 5.49% | ||
| 8 | J. Goldman & Co LP | 1,360,000 | 7,507,000 | 3.41% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 1,301,639 | 7,185,000 | 3.27% | ||
| 10 | NORTHERN TRUST CORP | 984,751 | 5,436,000 | 2.47% | ||
| 11 | Visium Asset Management, LP | 931,134 | 5,140,000 | 2.34% | ||
| 12 | VHCP Management, LLC | 788,370 | 4,352,000 | 1.98% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 787,000 | 4,345,000 | 1.98% | Put | |
| 14 | Ghost Tree Capital, LLC | 600,000 | 3,312,000 | 1.51% | ||
| 15 | Bank of New York Mellon Corp | 543,123 | 2,998,000 | 1.36% | ||
| 16 | J. Goldman & Co LP | 500,000 | 2,760,000 | 1.25% | Call | |
| 17 | MILLENNIUM MANAGEMENT LLC | 463,200 | 2,557,000 | 1.16% | Call | |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 438,700 | 2,422,000 | 1.10% | Call | |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 403,632 | 2,228,000 | 1.01% | ||
| 20 | GUGGENHEIM CAPITAL LLC | 394,786 | 2,179,000 | 0.99% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 386,040 | 2,130,000 | 0.97% | ||
| 22 | THB ASSET MANAGEMENT | 341,920 | 1,887,000 | 0.86% | ||
| 23 | GROUP ONE TRADING LLC | 334,666 | 1,847,000 | 0.84% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 317,319 | 1,752,000 | 0.80% | ||
| 25 | Informed Momentum Co LLC | 311,422 | 1,719,000 | 0.78% | ||
| 26 | GOLDMAN SACHS GROUP INC | 302,000 | 1,667,000 | 0.76% | Call | |
| 27 | Invesco Ltd. | 274,193 | 1,514,000 | 0.69% | ||
| 28 | AMERIPRISE FINANCIAL INC | 271,908 | 1,501,000 | 0.68% | ||
| 29 | DEUTSCHE BANK AG\ | 250,537 | 1,382,000 | 0.63% | ||
| 30 | MARSHALL WACE, LLP | 237,419 | 1,311,000 | 0.60% | ||
| 31 | BlackRock Investment Management, LLC | 217,747 | 1,202,000 | 0.55% | ||
| 32 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 208,058 | 1,148,000 | 0.52% | ||
| 33 | RUSSELL FRANK CO/ | 207,967 | 1,054,000 | 0.48% | ||
| 34 | DEERE & CO | 172,770 | 954,000 | 0.43% | ||
| 35 | UBS AG | 155,200 | 857,000 | 0.39% | Put | |
| 36 | CREDIT SUISSE AG/ | 146,715 | 809,000 | 0.37% | ||
| 37 | AQR CAPITAL MANAGEMENT LLC | 145,411 | 803,000 | 0.37% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 142,001 | 784,000 | 0.36% | ||
| 39 | TEACHERS ADVISORS, LLC | 126,818 | 700,000 | 0.32% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 127,000 | 676,000 | 0.31% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,800 | 629,000 | 0.29% | ||
| 42 | BARCLAYS PLC | 101,475 | 508,000 | 0.23% | ||
| 43 | BALYASNY ASSET MANAGEMENT L.P. | 90,700 | 501,000 | 0.23% | ||
| 44 | BARCLAYS PLC | 95,900 | 480,000 | 0.22% | Call | |
| 45 | ProShare Advisors LLC | 79,410 | 438,000 | 0.20% | ||
| 46 | D. E. Shaw & Co., Inc. | 72,165 | 398,000 | 0.18% | ||
| 47 | UBS AG | 70,671 | 390,000 | 0.18% | ||
| 48 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 70,000 | 386,000 | 0.18% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 68,334 | 377,204 | 0.17% | ||
| 50 | LMR Partners LLP | 62,124 | 343,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
