| 1 |
Aisling Capital LLC |
3,030,175 |
40,800,000 |
23.65% |
|
|
| 2 |
Canaan Partners VII LLC |
1,902,030 |
25,620,000 |
14.85% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,883,244 |
25,360,000 |
14.70% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
1,785,714 |
24,046,000 |
13.94% |
|
|
| 5 |
DISCOVERY CAPITAL MANAGEMENT, LLC / CT |
939,182 |
12,647,000 |
7.33% |
|
|
| 6 |
Granahan Investment Management, LLC |
529,733 |
7,133,000 |
4.13% |
|
|
| 7 |
BlackRock Fund Advisors |
370,780 |
4,993,000 |
2.89% |
|
|
| 8 |
VANGUARD GROUP INC |
299,387 |
4,030,000 |
2.34% |
|
|
| 9 |
Informed Momentum Co LLC |
197,888 |
2,664,000 |
1.54% |
|
|
| 10 |
STATE STREET CORP |
176,572 |
2,376,000 |
1.38% |
|
|
| 11 |
NORTHERN TRUST CORP |
163,932 |
2,208,000 |
1.28% |
|
|
| 12 |
MASON STREET ADVISORS, LLC |
138,790 |
1,869,000 |
1.08% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
123,604 |
1,664,000 |
0.96% |
|
|
| 14 |
SOPHROSYNE CAPITAL LLC |
105,500 |
1,422,000 |
0.82% |
|
|
| 15 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
95,841 |
1,291,000 |
0.75% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
95,167 |
1,282,000 |
0.74% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
76,150 |
1,025,000 |
0.59% |
|
|
| 18 |
Allianz Asset Management GmbH |
64,310 |
866,000 |
0.50% |
|
|
| 19 |
RENAISSANCE TECHNOLOGIES LLC |
60,300 |
812,000 |
0.47% |
|
|
| 20 |
Bank of New York Mellon Corp |
60,122 |
810,000 |
0.47% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
57,894 |
779,000 |
0.45% |
|
|
| 22 |
ROYAL BANK OF CANADA |
53,450 |
720,000 |
0.42% |
|
|
| 23 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
52,000 |
700,000 |
0.41% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
50,240 |
676,000 |
0.39% |
|
|
| 25 |
RUSSELL FRANK CO/ |
47,863 |
644,000 |
0.37% |
|
|
| 26 |
Nationwide Fund Advisors |
40,030 |
539,000 |
0.31% |
|
|
| 27 |
BlackRock Investment Management, LLC |
36,401 |
490,000 |
0.28% |
|
|
| 28 |
SSI INVESTMENT MANAGEMENT LLC |
33,985 |
459,000 |
0.27% |
|
|
| 29 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
25,300 |
358,000 |
0.21% |
|
|
| 30 |
TFS CAPITAL LLC |
25,976 |
350,000 |
0.20% |
|
|
| 31 |
MORGAN STANLEY |
24,621 |
332,000 |
0.19% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,588 |
317,000 |
0.18% |
|
|
| 33 |
AQR CAPITAL MANAGEMENT LLC |
21,600 |
291,000 |
0.17% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
21,241 |
286,000 |
0.17% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
18,322 |
247,000 |
0.14% |
|
|
| 36 |
CREDIT SUISSE AG/ |
18,205 |
245,000 |
0.14% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
16,493 |
222,000 |
0.13% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
14,493 |
194,000 |
0.11% |
|
|
| 39 |
ProShare Advisors LLC |
13,240 |
187,000 |
0.11% |
|
|
| 40 |
KANAWHA CAPITAL MANAGEMENT LLC |
13,000 |
175,000 |
0.10% |
|
|
| 41 |
SHEPHERD KAPLAN KROCHUK, LLC |
12,270 |
165,000 |
0.10% |
|
|
| 42 |
METROPOLITAN LIFE INSURANCE CO/NY |
11,766 |
158,000 |
0.09% |
|
|
| 43 |
RHUMBLINE ADVISERS |
11,607 |
156,000 |
0.09% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
11,081 |
149,000 |
0.09% |
|
|
| 45 |
J.P. Morgan Private Wealth Advisors LLC |
10,000 |
135,000 |
0.08% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
9,893 |
133,166 |
0.08% |
|
|
| 47 |
Lenox Wealth Advisors, LLC |
8,000 |
114,000 |
0.07% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
6,713 |
90,000 |
0.05% |
|
|
| 49 |
STRS OHIO |
6,200 |
83,000 |
0.05% |
|
|
| 50 |
Psagot Value Holdings Ltd. |
4,675 |
63,000 |
0.04% |
|
|
