| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 3,689,632 | 90,396,000 | 12.90% | ||
| 2 | JENNISON ASSOCIATES LLC | 3,172,670 | 77,730,000 | 11.09% | ||
| 3 | JPMORGAN CHASE & CO | 2,519,894 | 61,737,000 | 8.81% | ||
| 4 | ORBIMED ADVISORS LLC | 2,100,200 | 51,455,000 | 7.34% | ||
| 5 | FRANKLIN RESOURCES INC | 1,893,512 | 46,391,000 | 6.62% | ||
| 6 | WASATCH ADVISORS LP | 1,772,059 | 43,415,000 | 6.20% | ||
| 7 | NEXT CENTURY GROWTH INVESTORS LLC | 1,495,094 | 36,629,000 | 5.23% | ||
| 8 | FMR LLC | 1,027,243 | 25,167,000 | 3.59% | ||
| 9 | VANGUARD GROUP INC | 854,475 | 20,935,000 | 2.99% | ||
| 10 | Invesco Ltd. | 837,582 | 20,521,000 | 2.93% | ||
| 11 | BlackRock Fund Advisors | 758,973 | 18,595,000 | 2.65% | ||
| 12 | LORD, ABBETT & CO. LLC | 751,038 | 18,400,000 | 2.63% | ||
| 13 | SCHRODER INVESTMENT MANAGEMENT GROUP | 583,500 | 14,295,750 | 2.04% | ||
| 14 | Redmile Group, LLC | 559,622 | 13,711,000 | 1.96% | ||
| 15 | KING LUTHER CAPITAL MANAGEMENT CORP | 559,231 | 13,701,000 | 1.96% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 536,748 | 13,150,000 | 1.88% | ||
| 17 | ZEVENBERGEN CAPITAL INVESTMENTS LLC | 456,150 | 11,176,000 | 1.60% | ||
| 18 | STATE STREET CORP | 417,722 | 10,232,000 | 1.46% | ||
| 19 | NORTHERN TRUST CORP | 361,890 | 8,866,000 | 1.27% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 325,473 | 7,974,000 | 1.14% | ||
| 21 | CI Global Investments Inc. | 307,000 | 7,522,000 | 1.07% | ||
| 22 | Stephens Investment Management Group LLC | 273,090 | 6,691,000 | 0.96% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 237,607 | 5,821,000 | 0.83% | ||
| 24 | RUSSELL FRANK CO/ | 234,107 | 5,736,000 | 0.82% | ||
| 25 | SANDLER CAPITAL MANAGEMENT | 181,781 | 4,454,000 | 0.64% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 154,452 | 3,784,000 | 0.54% | ||
| 27 | Bank of New York Mellon Corp | 150,023 | 3,676,000 | 0.52% | ||
| 28 | OppenheimerFunds, Inc. | 148,175 | 3,631,000 | 0.52% | ||
| 29 | Elk Creek Partners, LLC | 127,008 | 3,112,000 | 0.44% | ||
| 30 | IRONBRIDGE CAPITAL MANAGEMENT LP | 113,163 | 2,772,000 | 0.40% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,600 | 2,685,000 | 0.38% | ||
| 32 | DRIEHAUS CAPITAL MANAGEMENT LLC | 91,036 | 2,230,000 | 0.32% | ||
| 33 | BlackRock Investment Management, LLC | 81,786 | 2,004,000 | 0.29% | ||
| 34 | First Light Asset Management, LLC | 74,482 | 1,825,000 | 0.26% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 74,167 | 1,818,000 | 0.26% | ||
| 36 | CREDIT SUISSE AG/ | 70,440 | 1,726,000 | 0.25% | ||
| 37 | PRINCIPAL FINANCIAL GROUP INC | 69,393 | 1,700,000 | 0.24% | ||
| 38 | NORGES BANK | 68,686 | 1,683,000 | 0.24% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,500 | 1,678,000 | 0.24% | ||
| 40 | Opaleye Management Inc. | 67,000 | 1,641,500 | 0.23% | ||
| 41 | WALL STREET ASSOCIATES | 59,475 | 1,457,000 | 0.21% | ||
| 42 | VIRTUS CAPITAL ADVISERS, LLC | 53,484 | 1,310,000 | 0.19% | ||
| 43 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 53,105 | 1,301,000 | 0.19% | ||
| 44 | KOPP INVESTMENT ADVISORS LLC | 53,036 | 1,299,000 | 0.19% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,785 | 1,269,000 | 0.18% | ||
| 46 | PANAGORA ASSET MANAGEMENT INC | 49,159 | 1,204,000 | 0.17% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 44,600 | 1,093,000 | 0.16% | ||
| 48 | MANAGED ACCOUNT ADVISORS LLC | 44,150 | 1,082,000 | 0.15% | ||
| 49 | BANK OF MONTREAL /CAN/ | 43,400 | 1,063,000 | 0.15% | Put | |
| 50 | RAYMOND JAMES & ASSOCIATES | 42,646 | 1,045,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
