| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 798,900 | 69,504,000 | 11.51% | ||
| 2 | Consonance Capital Management LP | 616,495 | 53,635,000 | 8.88% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 376,365 | 32,744,000 | 5.42% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 369,720 | 32,166,000 | 5.33% | ||
| 5 | THOMPSON SIEGEL & WALMSLEY LLC | 364,463 | 31,709,000 | 5.25% | ||
| 6 | ROYCE & ASSOCIATES LP | 355,065 | 30,891,000 | 5.12% | ||
| 7 | PointState Capital LP | 270,000 | 23,490,000 | 3.89% | ||
| 8 | BlackRock Fund Advisors | 255,499 | 22,228,000 | 3.68% | ||
| 9 | VANGUARD GROUP INC | 228,438 | 19,874,000 | 3.29% | ||
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 215,400 | 18,740,000 | 3.10% | Put | |
| 11 | GREAT POINT PARTNERS LLC | 205,858 | 17,910,000 | 2.97% | ||
| 12 | MORGAN STANLEY | 188,790 | 16,425,000 | 2.72% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 169,800 | 14,773,000 | 2.45% | Call | |
| 14 | STATE STREET CORP | 131,550 | 11,446,000 | 1.90% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 121,432 | 10,565,000 | 1.75% | ||
| 16 | Invesco Ltd. | 117,800 | 10,249,000 | 1.70% | ||
| 17 | KENNEDY CAPITAL MANAGEMENT LLC | 110,921 | 9,650,000 | 1.60% | ||
| 18 | Artal Group S.A. | 100,000 | 8,700,000 | 1.44% | Call | |
| 19 | NORTHERN TRUST CORP | 97,712 | 8,500,000 | 1.41% | ||
| 20 | STIFEL FINANCIAL CORP | 93,060 | 8,096,000 | 1.34% | ||
| 21 | Alistair Capital Management, L.L.C. | 84,938 | 7,390,000 | 1.22% | ||
| 22 | SAC Capital Advisors LP | 83,700 | 7,282,000 | 1.21% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,299 | 6,986,000 | 1.16% | ||
| 24 | SAMLYN CAPITAL, LLC | 80,000 | 6,960,000 | 1.15% | ||
| 25 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 75,000 | 6,525,000 | 1.08% | Call | |
| 26 | March Altus Capital Management LP | 69,960 | 6,087,000 | 1.01% | ||
| 27 | Independence Capital Asset Partners, LLC | 69,241 | 6,024,000 | 1.00% | ||
| 28 | Bank of New York Mellon Corp | 55,675 | 4,844,000 | 0.80% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 52,386 | 4,557,000 | 0.75% | ||
| 30 | AMERICAN CAPITAL MANAGEMENT INC | 48,750 | 4,241,000 | 0.70% | ||
| 31 | Jefferies Group LLC | 43,600 | 3,793,000 | 0.63% | Call | |
| 32 | Breithorn Capital Management | 42,958 | 3,737,000 | 0.62% | ||
| 33 | BAKER BROS. ADVISORS LP | 40,309 | 3,507,000 | 0.58% | ||
| 34 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 40,017 | 3,481,000 | 0.58% | ||
| 35 | JPMORGAN CHASE & CO | 39,986 | 3,479,000 | 0.58% | ||
| 36 | MACQUARIE GROUP LTD | 37,000 | 3,219,000 | 0.53% | ||
| 37 | HBK INVESTMENTS L P | 36,682 | 3,191,000 | 0.53% | ||
| 38 | AQR CAPITAL MANAGEMENT LLC | 35,416 | 3,081,000 | 0.51% | ||
| 39 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 33,600 | 2,923,000 | 0.48% | ||
| 40 | Visium Asset Management, LP | 32,404 | 2,820,000 | 0.47% | ||
| 41 | TURNER INVESTMENTS LLC | 31,610 | 2,750,000 | 0.46% | ||
| 42 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 29,589 | 2,574,000 | 0.43% | ||
| 43 | Ghost Tree Capital, LLC | 27,500 | 2,393,000 | 0.40% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,493 | 2,392,000 | 0.40% | ||
| 45 | BLACKROCK ADVISORS LLC | 27,380 | 2,382,000 | 0.39% | ||
| 46 | SEGALL BRYANT & HAMILL, LLC | 25,969 | 2,259,000 | 0.37% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 25,200 | 2,037,000 | 0.34% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,106 | 1,837,000 | 0.30% | ||
| 49 | D. E. Shaw & Co., Inc. | 20,988 | 1,826,000 | 0.30% | ||
| 50 | Hatteras Alternative Mutual Funds, LLC | 20,558 | 1,789,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
