| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,996,030 | 77,298,000 | 19.80% | ||
| 2 | NEA Management Company, LLC | 2,884,221 | 74,413,000 | 19.06% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,535,798 | 65,424,000 | 16.76% | ||
| 4 | Highland Management Partners VII, LLC | 1,848,920 | 47,702,000 | 12.22% | ||
| 5 | Consonance Capital Management LP | 1,026,092 | 26,473,000 | 6.78% | ||
| 6 | GREAT POINT PARTNERS LLC | 493,751 | 12,739,000 | 3.26% | ||
| 7 | WELLS FARGO & COMPANY/MN | 392,164 | 10,118,000 | 2.59% | ||
| 8 | VANGUARD GROUP INC | 315,760 | 8,147,000 | 2.09% | ||
| 9 | FRANKLIN RESOURCES INC | 309,952 | 7,997,000 | 2.05% | ||
| 10 | BlackRock Fund Advisors | 235,350 | 6,072,000 | 1.56% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 164,422 | 4,242,000 | 1.09% | ||
| 12 | LORD, ABBETT & CO. LLC | 156,987 | 4,050,000 | 1.04% | ||
| 13 | NORTHERN TRUST CORP | 131,425 | 3,390,000 | 0.87% | ||
| 14 | Allianz Asset Management GmbH | 130,600 | 3,369,000 | 0.86% | ||
| 15 | STATE STREET CORP | 124,530 | 3,213,000 | 0.82% | ||
| 16 | RICE HALL JAMES & ASSOCIATES, LLC | 113,553 | 2,930,000 | 0.75% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 100,692 | 2,598,000 | 0.67% | ||
| 18 | MASON STREET ADVISORS, LLC | 84,500 | 2,180,000 | 0.56% | ||
| 19 | AlphaOne Investment Services, LLC | 83,142 | 2,145,000 | 0.55% | ||
| 20 | Rhenman & Partners Asset Management AB | 73,702 | 1,902,000 | 0.49% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 71,700 | 1,850,000 | 0.47% | ||
| 22 | Palo Alto Investors LP | 62,700 | 1,618,000 | 0.41% | ||
| 23 | Abingworth LLP | 62,500 | 1,612,000 | 0.41% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,432 | 1,611,000 | 0.41% | ||
| 25 | BNP Paribas Asset Management Holding S.A. | 58,035 | 1,497,000 | 0.38% | ||
| 26 | TFS CAPITAL LLC | 45,839 | 1,183,000 | 0.30% | ||
| 27 | AMERIPRISE FINANCIAL INC | 42,042 | 1,084,000 | 0.28% | ||
| 28 | HAMILTON LANE ADVISORS LLC | 39,333 | 1,015,000 | 0.26% | ||
| 29 | Bank of New York Mellon Corp | 39,273 | 1,013,000 | 0.26% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 36,600 | 944,000 | 0.24% | ||
| 31 | MACQUARIE GROUP LTD | 35,062 | 905,000 | 0.23% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 34,251 | 883,000 | 0.23% | ||
| 33 | D. E. Shaw & Co., Inc. | 33,220 | 857,000 | 0.22% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 28,280 | 730,000 | 0.19% | ||
| 35 | Nationwide Fund Advisors | 26,163 | 675,000 | 0.17% | ||
| 36 | Liberty Mutual Group Asset Management Inc. | 23,600 | 609,000 | 0.16% | ||
| 37 | BlackRock Investment Management, LLC | 23,545 | 607,000 | 0.16% | ||
| 38 | GW&K Investment Management, LLC | 21,585 | 557,000 | 0.14% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,126 | 520,000 | 0.13% | ||
| 40 | CITADEL ADVISORS LLC | 19,511 | 503,000 | 0.13% | ||
| 41 | AQR CAPITAL MANAGEMENT LLC | 18,809 | 485,000 | 0.12% | ||
| 42 | TEACHERS ADVISORS, LLC | 13,312 | 343,000 | 0.09% | ||
| 43 | VIRGINIA RETIREMENT SYSTEMS ET Al | 12,600 | 325,000 | 0.08% | ||
| 44 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 11,050 | 285,000 | 0.07% | ||
| 45 | GAM Holding AG | 10,700 | 276,000 | 0.07% | ||
| 46 | MORGAN STANLEY | 10,047 | 259,000 | 0.07% | ||
| 47 | ProShare Advisors LLC | 8,490 | 219,000 | 0.06% | ||
| 48 | Invesco Ltd. | 7,918 | 204,000 | 0.05% | ||
| 49 | STRS OHIO | 7,600 | 196,000 | 0.05% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 7,386 | 191,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
