| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,027,338 | 79,014,000 | 19.12% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,524,998 | 65,903,000 | 15.95% | ||
| 3 | NEA Management Company, LLC | 2,384,221 | 62,228,000 | 15.06% | ||
| 4 | Highland Management Partners VII, LLC | 1,811,020 | 47,268,000 | 11.44% | ||
| 5 | Consonance Capital Management LP | 1,279,048 | 33,383,000 | 8.08% | ||
| 6 | GREAT POINT PARTNERS LLC | 657,984 | 17,174,000 | 4.16% | ||
| 7 | WELLS FARGO & COMPANY/MN | 395,229 | 10,315,000 | 2.50% | ||
| 8 | BlackRock Fund Advisors | 335,134 | 8,747,000 | 2.12% | ||
| 9 | VANGUARD GROUP INC | 323,275 | 8,437,000 | 2.04% | ||
| 10 | FRANKLIN RESOURCES INC | 276,352 | 7,213,000 | 1.75% | ||
| 11 | LORD, ABBETT & CO. LLC | 192,719 | 5,030,000 | 1.22% | ||
| 12 | STATE STREET CORP | 169,308 | 4,420,000 | 1.07% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 155,852 | 4,068,000 | 0.98% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 129,533 | 3,381,000 | 0.82% | ||
| 15 | Allianz Asset Management GmbH | 118,375 | 3,090,000 | 0.75% | ||
| 16 | NORTHERN TRUST CORP | 114,718 | 2,993,000 | 0.72% | ||
| 17 | RICE HALL JAMES & ASSOCIATES, LLC | 113,144 | 2,953,000 | 0.71% | ||
| 18 | Invesco Ltd. | 92,040 | 2,402,000 | 0.58% | ||
| 19 | TFS CAPITAL LLC | 85,284 | 2,226,000 | 0.54% | ||
| 20 | MASON STREET ADVISORS, LLC | 84,500 | 2,205,000 | 0.53% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 76,300 | 1,991,000 | 0.48% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 75,388 | 1,968,000 | 0.48% | ||
| 23 | Rhenman & Partners Asset Management AB | 70,369 | 1,837,000 | 0.44% | ||
| 24 | MORGAN STANLEY | 68,705 | 1,793,000 | 0.43% | ||
| 25 | Palo Alto Investors LP | 62,700 | 1,636,000 | 0.40% | ||
| 26 | Abingworth LLP | 62,500 | 1,628,000 | 0.39% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 61,934 | 1,617,000 | 0.39% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,932 | 1,512,000 | 0.37% | ||
| 29 | D. E. Shaw & Co., Inc. | 54,032 | 1,410,000 | 0.34% | ||
| 30 | Bank of New York Mellon Corp | 50,339 | 1,314,000 | 0.32% | ||
| 31 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 49,350 | 1,288,000 | 0.31% | ||
| 32 | GW&K Investment Management, LLC | 46,205 | 1,206,000 | 0.29% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 44,403 | 1,158,000 | 0.28% | ||
| 34 | BlackRock Investment Management, LLC | 43,207 | 1,128,000 | 0.27% | ||
| 35 | AMERIPRISE FINANCIAL INC | 41,412 | 1,081,000 | 0.26% | ||
| 36 | MACQUARIE GROUP LTD | 41,233 | 1,076,000 | 0.26% | ||
| 37 | HAMILTON LANE ADVISORS LLC | 38,265 | 999,000 | 0.24% | ||
| 38 | Jefferies Group LLC | 37,500 | 979,000 | 0.24% | ||
| 39 | CREDIT SUISSE AG/ | 35,337 | 922,000 | 0.22% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 34,400 | 898,000 | 0.22% | ||
| 41 | Nationwide Fund Advisors | 33,580 | 876,000 | 0.21% | ||
| 42 | SMITH ASSET MANAGEMENT GROUP LP | 32,110 | 838,000 | 0.20% | ||
| 43 | CITADEL ADVISORS LLC | 30,621 | 799,000 | 0.19% | ||
| 44 | STRS OHIO | 28,000 | 731,000 | 0.18% | ||
| 45 | BLACKROCK ADVISORS LLC | 27,086 | 707,000 | 0.17% | ||
| 46 | JPMORGAN CHASE & CO | 24,963 | 652,000 | 0.16% | ||
| 47 | Numeric Investors LLC | 25,000 | 652,000 | 0.16% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,832 | 648,000 | 0.16% | ||
| 49 | Spark Investment Management LLC | 23,800 | 619,000 | 0.15% | ||
| 50 | DEERE & CO | 20,929 | 546,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
