| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,386,119 | 123,102,000 | 20.04% | ||
| 2 | VANGUARD GROUP INC | 9,007,633 | 57,199,000 | 9.31% | ||
| 3 | WESTFIELD CAPITAL MANAGEMENT CO LP | 8,894,008 | 56,477,000 | 9.19% | ||
| 4 | BlackRock Fund Advisors | 6,226,723 | 39,540,000 | 6.44% | ||
| 5 | Consonance Capital Management LP | 5,950,225 | 37,784,000 | 6.15% | ||
| 6 | TIAA CREF INVESTMENT MANAGEMENT LLC | 5,806,784 | 36,873,000 | 6.00% | ||
| 7 | STATE STREET CORP | 4,592,802 | 29,163,000 | 4.75% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,476,313 | 22,075,000 | 3.59% | ||
| 9 | TEACHERS ADVISORS, LLC | 2,762,416 | 17,541,000 | 2.85% | ||
| 10 | PUTNAM INVESTMENTS LLC | 2,654,373 | 16,855,000 | 2.74% | ||
| 11 | GREAT POINT PARTNERS LLC | 2,442,159 | 15,508,000 | 2.52% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,950,306 | 12,384,000 | 2.02% | ||
| 13 | Lagoda Investment Management, L.P. | 1,870,777 | 11,879,000 | 1.93% | ||
| 14 | Cannell & Co. | 1,611,678 | 10,234,000 | 1.67% | ||
| 15 | DEUTSCHE BANK AG\ | 1,470,909 | 9,338,000 | 1.52% | ||
| 16 | NORTHERN TRUST CORP | 1,373,741 | 8,723,000 | 1.42% | ||
| 17 | FRANKLIN RESOURCES INC | 1,298,400 | 8,245,000 | 1.34% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 975,000 | 6,191,000 | 1.01% | ||
| 19 | AXA S.A. | 948,827 | 6,025,000 | 0.98% | ||
| 20 | MORGAN STANLEY | 896,420 | 5,693,000 | 0.93% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 843,126 | 5,353,000 | 0.87% | ||
| 22 | ROYAL BANK OF CANADA | 715,064 | 4,540,000 | 0.74% | ||
| 23 | NORGES BANK | 693,611 | 4,207,000 | 0.68% | ||
| 24 | Bank of New York Mellon Corp | 658,214 | 4,180,000 | 0.68% | ||
| 25 | INDUS CAPITAL PARTNERS, LLC | 500,000 | 3,175,000 | 0.52% | ||
| 26 | BlackRock Investment Management, LLC | 470,238 | 2,986,000 | 0.49% | ||
| 27 | Portolan Capital Management, LLC | 412,189 | 2,617,000 | 0.43% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 396,313 | 2,517,000 | 0.41% | ||
| 29 | CREDIT SUISSE AG/ | 357,075 | 2,268,000 | 0.37% | ||
| 30 | BLAIR WILLIAM & CO/IL | 309,100 | 1,963,000 | 0.32% | ||
| 31 | BLACKROCK ADVISORS LLC | 306,854 | 1,949,000 | 0.32% | ||
| 32 | Tekla Capital Management LLC | 286,000 | 1,816,000 | 0.30% | ||
| 33 | MARSHALL WACE, LLP | 277,641 | 1,763,000 | 0.29% | ||
| 34 | QS Investors, LLC | 277,355 | 1,761,000 | 0.29% | ||
| 35 | CITADEL ADVISORS LLC | 266,634 | 1,693,000 | 0.28% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 260,057 | 1,651,000 | 0.27% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 258,314 | 1,640,000 | 0.27% | ||
| 38 | ALTFEST L J & CO INC | 39,490 | 1,508,000 | 0.25% | ||
| 39 | Alberta Investment Management Corp | 234,480 | 1,489,000 | 0.24% | ||
| 40 | JPMORGAN CHASE & CO | 233,464 | 1,482,000 | 0.24% | ||
| 41 | Candriam S.C.A. | 224,000 | 1,422,000 | 0.23% | ||
| 42 | STONERIDGE INVESTMENT PARTNERS LLC | 221,838 | 1,409,000 | 0.23% | ||
| 43 | BROWN ADVISORY INC | 210,294 | 1,335,000 | 0.22% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 187,400 | 1,190,000 | 0.19% | ||
| 45 | Swiss National Bank | 185,600 | 1,179,000 | 0.19% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,400 | 1,133,000 | 0.18% | Put | |
| 47 | BANK OF AMERICA CORP /DE/ | 162,077 | 1,029,000 | 0.17% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,469 | 1,025,000 | 0.17% | ||
| 49 | CAMBRIDGE TRUST CO | 143,003 | 908,000 | 0.15% | ||
| 50 | J.P. Morgan Private Wealth Advisors LLC | 140,000 | 889,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
