| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,679,748 | 160,730,000 | 16.67% | ||
| 2 | BlackRock Fund Advisors | 5,983,161 | 90,047,000 | 9.34% | ||
| 3 | VANGUARD GROUP INC | 5,757,681 | 86,654,000 | 8.99% | ||
| 4 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 4,468,368 | 67,249,000 | 6.98% | ||
| 5 | Invesco Ltd. | 3,623,003 | 54,526,000 | 5.66% | ||
| 6 | ORBIMED ADVISORS LLC | 2,951,968 | 44,427,000 | 4.61% | ||
| 7 | PRIMECAP MANAGEMENT CO/CA/ | 2,739,900 | 41,235,000 | 4.28% | ||
| 8 | Fiera Capital Corp | 1,988,280 | 29,924,000 | 3.10% | ||
| 9 | STATE STREET CORP | 1,877,945 | 28,266,000 | 2.93% | ||
| 10 | D. E. Shaw & Co., Inc. | 1,815,595 | 27,325,000 | 2.83% | ||
| 11 | Palo Alto Investors LP | 1,727,380 | 25,997,000 | 2.70% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,716,754 | 25,837,000 | 2.68% | ||
| 13 | NORGES BANK | 1,504,994 | 22,650,000 | 2.35% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 1,244,574 | 18,731,000 | 1.94% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,010,724 | 15,211,000 | 1.58% | ||
| 16 | SECTOR GAMMA AS | 855,265 | 12,872,000 | 1.34% | ||
| 17 | BANK OF AMERICA CORP /DE/ | 787,199 | 11,847,000 | 1.23% | ||
| 18 | NORTHERN TRUST CORP | 775,056 | 11,665,000 | 1.21% | ||
| 19 | Bank of New York Mellon Corp | 760,975 | 11,452,000 | 1.19% | ||
| 20 | DIMENSIONAL FUND ADVISORS LP | 727,425 | 10,948,000 | 1.14% | ||
| 21 | SENZAR ASSET MANAGEMENT, LLC | 531,898 | 8,005,000 | 0.83% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 494,670 | 7,445,000 | 0.77% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 478,588 | 7,202,000 | 0.75% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 397,100 | 5,976,000 | 0.62% | ||
| 25 | TEACHERS ADVISORS, LLC | 391,672 | 5,895,000 | 0.61% | ||
| 26 | JPMORGAN CHASE & CO | 385,585 | 5,803,000 | 0.60% | ||
| 27 | SECTORAL ASSET MANAGEMENT INC | 379,500 | 5,711,000 | 0.59% | ||
| 28 | BlackRock Investment Management, LLC | 347,406 | 5,228,000 | 0.54% | ||
| 29 | GOLDMAN SACHS GROUP INC | 346,307 | 5,212,000 | 0.54% | ||
| 30 | Opaleye Management Inc. | 330,000 | 4,967,000 | 0.52% | ||
| 31 | AMERIPRISE FINANCIAL INC | 323,492 | 4,870,000 | 0.51% | ||
| 32 | Tekla Capital Management LLC | 306,600 | 4,614,000 | 0.48% | ||
| 33 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 264,718 | 3,984,000 | 0.41% | ||
| 34 | SAMLYN CAPITAL, LLC | 264,000 | 3,973,000 | 0.41% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 261,737 | 3,939,000 | 0.41% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 249,268 | 3,752,000 | 0.39% | ||
| 37 | MORGAN STANLEY | 245,655 | 3,697,000 | 0.38% | ||
| 38 | WELLS FARGO & COMPANY/MN | 210,190 | 3,164,000 | 0.33% | ||
| 39 | QS Investors, LLC | 199,165 | 2,997,000 | 0.31% | ||
| 40 | CITIGROUP INC | 187,080 | 2,815,000 | 0.29% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 185,319 | 2,789,000 | 0.29% | ||
| 42 | South Dakota Investment Council | 150,652 | 2,267,000 | 0.24% | ||
| 43 | TWO SIGMA ADVISERS, LP | 139,490 | 2,099,000 | 0.22% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 136,000 | 2,047,000 | 0.21% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 133,876 | 2,015,000 | 0.21% | ||
| 46 | BlackRock Group LTD | 133,661 | 2,011,000 | 0.21% | ||
| 47 | PICTET ASSET MANAGEMENT LTD | 127,929 | 1,925,000 | 0.20% | ||
| 48 | AMICA MUTUAL INSURANCE CO | 119,449 | 1,798,000 | 0.19% | ||
| 49 | PNC FINANCIAL SERVICES GROUP, INC. | 114,454 | 1,721,000 | 0.18% | ||
| 50 | Swiss National Bank | 110,100 | 1,657,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
