| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | UNITED THERAPEUTICS | 1,868,815 | 268,044,000 | 15.29% | ||
| 2 | ABIOMED INC | 1,903,584 | 214,496,000 | 12.24% | ||
| 3 | CLOVIS ONCOLOGY INC | 3,804,088 | 168,978,000 | 9.64% | ||
| 4 | BIOMARIN | 1,960,219 | 162,385,000 | 9.26% | ||
| 5 | AMAG PHARMACEUTICALS INC COM | 3,344,620 | 116,393,000 | 6.64% | ||
| 6 | ALEXION PHARMACEUTIC | 713,742 | 87,326,000 | 4.98% | ||
| 7 | ZELTIQ AESTHETICS INCORPORATED | 1,720,763 | 74,888,000 | 4.27% | ||
| 8 | INSMED INC COM PAR .01 | 5,446,516 | 72,057,000 | 4.11% | ||
| 9 | VANDA PHARMACEUTICALS INC COM | 4,203,270 | 67,042,000 | 3.82% | ||
| 10 | Wright Medical Group NV | 2,604,593 | 59,854,000 | 3.41% | ||
| 11 | SAGE THERAPEUTICS | 1,009,930 | 51,567,000 | 2.94% | ||
| 12 | PROTHENA CORP PLC | 993,855 | 48,888,000 | 2.79% | ||
| 13 | ACADIA PHARMACEUTICALS INC COM | 1,532,030 | 44,184,000 | 2.52% | ||
| 14 | STAAR SURGICAL CO | 3,386,245 | 36,741,000 | 2.10% | ||
| 15 | EPIZYME INC COM | 3,035,796 | 36,733,000 | 2.10% | ||
| 16 | CELGENE CORP | 295,240 | 34,174,000 | 1.95% | ||
| 17 | ARIAD PHARMACEUTICALS INC | 2,682,017 | 33,364,000 | 1.90% | ||
| 18 | AMICUS THERAPEUTICS INC | 6,410,030 | 31,858,000 | 1.82% | ||
| 19 | KARYOPHARM THERAPEUTICS INC COM | 3,200,396 | 30,084,000 | 1.72% | ||
| 20 | Momenta Pharmaceuticals Inc | 1,727,380 | 25,997,000 | 1.48% | ||
| 21 | GILEAD SCIENCES INC | 318,400 | 22,801,000 | 1.30% | ||
| 22 | SHIRE PLC | 124,100 | 21,144,000 | 1.21% | ||
| 23 | RIGEL PHARMACEUTICAL INC | 4,176,623 | 9,940,000 | 0.57% | ||
| 24 | AIMMUNE THERAPEUTICS INC COM | 379,727 | 7,765,000 | 0.44% | ||
| 25 | EXACT SCIENCES CORP | 396,976 | 5,304,000 | 0.30% | ||
| 26 | Sunesis Pharmaceuticals, Inc. | 1,162,473 | 4,208,000 | 0.24% | ||
| 27 | ALIGN TECHNOLOGY INC | 38,707 | 3,721,000 | 0.21% | ||
| 28 | ALIMERA SCIENCES INC | 3,013,793 | 3,255,000 | 0.19% | ||
| 29 | ACELRX PHARMACEUTICALS INC | 1,032,715 | 2,685,000 | 0.15% | ||
| 30 | CYTOKINETICS INC | 123,686 | 1,503,000 | 0.09% | ||
| 31 | INTREXON CORP | 41,900 | 1,018,000 | 0.06% | ||
| 32 | CEMPRA INC | 340,320 | 953,000 | 0.05% | ||
| 33 | IDERA PHARMACEUTICALS INC | 616,355 | 925,000 | 0.05% | ||
| 34 | SOPHIRIS BIO INC | 247,000 | 692,000 | 0.04% | ||
| 35 | ALCOBRA LTD | 272,788 | 573,000 | 0.03% | ||
| 36 | HISTOGENICS CORP | 302,922 | 506,000 | 0.03% | ||
| 37 | Dicerna Pharmaceuticals | 158,279 | 456,000 | 0.03% | ||
| 38 | ZOGENIX INC | 29,500 | 358,000 | 0.02% |
Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001306923-17-000015, filed 2017.02.15).
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
