| 1 |
ORBIMED ADVISORS LLC |
3,220,429 |
14,202,000 |
22.39% |
|
|
| 2 |
NEA Management Company, LLC |
3,220,433 |
14,202,000 |
22.39% |
|
|
| 3 |
TPG Group Holdings (SBS) Advisors, Inc. |
2,989,282 |
13,183,000 |
20.78% |
|
|
| 4 |
DRILL CRAIG A |
1,500,000 |
6,615,000 |
10.43% |
|
|
| 5 |
Aisling Capital LLC |
1,122,417 |
4,950,000 |
7.80% |
|
|
| 6 |
FMR LLC |
1,118,704 |
4,933,000 |
7.78% |
|
|
| 7 |
JPMORGAN CHASE & CO |
274,700 |
1,211,000 |
1.91% |
|
|
| 8 |
Rock Springs Capital Management LP |
250,000 |
1,103,000 |
1.74% |
|
|
| 9 |
BlackRock Fund Advisors |
130,740 |
577,000 |
0.91% |
|
|
| 10 |
Birchview Capital, LP |
85,900 |
379,000 |
0.60% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
79,919 |
352,000 |
0.55% |
|
|
| 12 |
Weiss Multi-Strategy Advisers LLC |
61,000 |
269,000 |
0.42% |
|
|
| 13 |
PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. |
44,231 |
195,000 |
0.31% |
|
|
| 14 |
NORTHERN TRUST CORP |
42,789 |
189,000 |
0.30% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
38,478 |
170,000 |
0.27% |
|
|
| 16 |
STATE STREET CORP |
25,400 |
111,000 |
0.18% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
24,067 |
106,000 |
0.17% |
|
|
| 18 |
Nationwide Fund Advisors |
19,569 |
86,000 |
0.14% |
|
|
| 19 |
A.R.T. Advisors, LLC |
18,442 |
81,000 |
0.13% |
|
|
| 20 |
Spark Investment Management LLC |
17,300 |
75,000 |
0.12% |
|
|
| 21 |
VANGUARD GROUP INC |
13,749 |
61,000 |
0.10% |
|
|
| 22 |
BlackRock Investment Management, LLC |
12,124 |
53,000 |
0.08% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,800 |
53,000 |
0.08% |
|
|
| 24 |
Virtu KCG Holdings LLC |
11,583 |
51,000 |
0.08% |
|
|
| 25 |
Cannell & Co. |
10,550 |
47,000 |
0.07% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,340 |
41,000 |
0.06% |
|
|
| 27 |
CITIGROUP INC |
7,934 |
36,000 |
0.06% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
5,684 |
25,000 |
0.04% |
|
|
| 29 |
UBS Group AG |
3,273 |
14,000 |
0.02% |
|
|
| 30 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,158 |
13,927 |
0.02% |
|
|
| 31 |
MORGAN STANLEY |
2,003 |
9,000 |
0.01% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
1,720 |
8,000 |
0.01% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
1,703 |
8,000 |
0.01% |
|
|
| 34 |
STRS OHIO |
1,700 |
7,000 |
0.01% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
1,158 |
5,000 |
0.01% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
746 |
3,000 |
0.00% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
533 |
2,000 |
0.00% |
|
|
| 38 |
BARCLAYS PLC |
287 |
1,000 |
0.00% |
|
|
| 39 |
ROYAL BANK OF CANADA |
95 |
0 |
0.00% |
|
|
| 40 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
111 |
0 |
0.00% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
3 |
0 |
0.00% |
|
|
