| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NORTH TIDE CAPITAL, LLC | 1,800,000 | 64,602,000 | 10.32% | ||
| 2 | Consonance Capital Management LP | 1,580,218 | 56,714,000 | 9.06% | ||
| 3 | Camber Capital Management LP | 1,500,000 | 53,835,000 | 8.60% | ||
| 4 | VANGUARD GROUP INC | 1,249,607 | 44,848,000 | 7.16% | ||
| 5 | SEGALL BRYANT & HAMILL, LLC | 934,071 | 33,524,000 | 5.36% | ||
| 6 | SNYDER CAPITAL MANAGEMENT L P | 841,991 | 30,219,000 | 4.83% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 755,911 | 27,130,000 | 4.33% | ||
| 8 | DIMENSIONAL FUND ADVISORS LP | 691,648 | 24,821,000 | 3.97% | ||
| 9 | DIAMOND HILL CAPITAL MANAGEMENT INC | 689,591 | 24,749,000 | 3.95% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 630,222 | 22,619,000 | 3.61% | ||
| 11 | BlackRock Fund Advisors | 457,982 | 16,437,000 | 2.63% | ||
| 12 | Numeric Investors LLC | 390,660 | 14,021,000 | 2.24% | ||
| 13 | SENZAR ASSET MANAGEMENT, LLC | 343,201 | 12,317,000 | 1.97% | ||
| 14 | STATE STREET CORP | 328,344 | 11,784,000 | 1.88% | ||
| 15 | Krensavage Asset Management, LLC | 309,698 | 11,115,000 | 1.78% | ||
| 16 | GREAT POINT PARTNERS LLC | 300,000 | 10,767,000 | 1.72% | ||
| 17 | AMERIPRISE FINANCIAL INC | 269,702 | 9,680,000 | 1.55% | ||
| 18 | D. E. Shaw & Co., Inc. | 268,715 | 9,644,000 | 1.54% | ||
| 19 | AQR CAPITAL MANAGEMENT LLC | 268,688 | 9,643,000 | 1.54% | ||
| 20 | NORGES BANK | 256,049 | 9,190,000 | 1.47% | ||
| 21 | NORTHERN TRUST CORP | 249,888 | 8,969,000 | 1.43% | ||
| 22 | GABELLI FUNDS LLC | 215,006 | 7,717,000 | 1.23% | ||
| 23 | KENNEDY CAPITAL MANAGEMENT LLC | 196,699 | 7,060,000 | 1.13% | ||
| 24 | LSV ASSET MANAGEMENT | 172,976 | 6,208,000 | 0.99% | ||
| 25 | Adirondack Research & Management Inc. | 163,586 | 5,871,000 | 0.94% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 143,039 | 5,134,000 | 0.82% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 119,344 | 4,282,000 | 0.68% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 107,995 | 3,876,000 | 0.62% | ||
| 29 | ROYCE & ASSOCIATES LP | 105,400 | 3,783,000 | 0.60% | ||
| 30 | Bank of New York Mellon Corp | 104,124 | 3,737,000 | 0.60% | ||
| 31 | GAMCO INVESTORS, INC. ET AL | 95,925 | 3,443,000 | 0.55% | ||
| 32 | GOLDMAN SACHS GROUP INC | 92,146 | 3,307,000 | 0.53% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 86,381 | 3,100,000 | 0.50% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 93,800 | 2,954,000 | 0.47% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 76,434 | 2,744,000 | 0.44% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,008 | 2,584,000 | 0.41% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,644 | 2,320,000 | 0.37% | ||
| 38 | ACUTA CAPITAL PARTNERS, LLC | 60,000 | 2,153,000 | 0.34% | ||
| 39 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 59,481 | 2,134,000 | 0.34% | ||
| 40 | BlackRock Investment Management, LLC | 58,875 | 2,113,000 | 0.34% | ||
| 41 | DEUTSCHE BANK AG\ | 55,359 | 1,985,000 | 0.32% | ||
| 42 | RUSSELL FRANK CO/ | 50,398 | 1,809,000 | 0.29% | ||
| 43 | GSA CAPITAL PARTNERS LLP | 49,743 | 1,785,000 | 0.29% | ||
| 44 | MARTINGALE ASSET MANAGEMENT L P | 47,972 | 1,722,000 | 0.28% | ||
| 45 | TWO SIGMA ADVISERS, LP | 44,974 | 1,614,000 | 0.26% | ||
| 46 | RENAISSANCE TECHNOLOGIES LLC | 43,824 | 1,573,000 | 0.25% | ||
| 47 | STIFEL FINANCIAL CORP | 43,543 | 1,563,000 | 0.25% | ||
| 48 | AXA S.A. | 42,300 | 1,518,000 | 0.24% | ||
| 49 | MORGAN STANLEY | 41,606 | 1,492,000 | 0.24% | ||
| 50 | PANAGORA ASSET MANAGEMENT INC | 40,352 | 1,448,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
