| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Longwood Fund GP, LLC | 2,820,607 | 124,727,000 | 14.64% | ||
| 2 | FMR LLC | 2,612,367 | 115,519,000 | 13.56% | ||
| 3 | Deer VII & Co. Ltd. | 2,318,940 | 102,544,000 | 12.04% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 2,078,886 | 91,928,000 | 10.79% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,405,000 | 62,129,000 | 7.29% | ||
| 6 | JENNISON ASSOCIATES LLC | 1,047,459 | 46,319,000 | 5.44% | ||
| 7 | Cormorant Asset Management, LP | 747,000 | 33,032,000 | 3.88% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 627,050 | 27,728,000 | 3.25% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 493,967 | 21,843,000 | 2.56% | ||
| 10 | BBT Capital Management, LLC | 422,800 | 18,696,000 | 2.19% | ||
| 11 | BlackRock Fund Advisors | 420,042 | 18,574,000 | 2.18% | ||
| 12 | VANGUARD GROUP INC | 413,846 | 18,300,000 | 2.15% | ||
| 13 | Third Security, LLC | 373,224 | 16,504,000 | 1.94% | ||
| 14 | FRANKLIN RESOURCES INC | 350,754 | 15,510,000 | 1.82% | ||
| 15 | Asset Management One Co., Ltd. | 304,391 | 13,868,000 | 1.63% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 237,319 | 10,494,000 | 1.23% | ||
| 17 | STATE STREET CORP | 212,925 | 9,415,000 | 1.11% | ||
| 18 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 189,122 | 8,363,000 | 0.98% | ||
| 19 | JPMORGAN CHASE & CO | 160,393 | 7,093,000 | 0.83% | ||
| 20 | MORGAN STANLEY | 152,904 | 6,761,000 | 0.79% | ||
| 21 | NORTHERN TRUST CORP | 150,721 | 6,665,000 | 0.78% | ||
| 22 | Catalyst Capital Advisors LLC | 117,147 | 5,180,000 | 0.61% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 106,186 | 4,695,000 | 0.55% | ||
| 24 | Nicholas Investment Partners, LP | 98,040 | 4,335,000 | 0.51% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 84,228 | 3,725,000 | 0.44% | ||
| 26 | EMERALD ADVISERS, LLC | 80,741 | 3,570,000 | 0.42% | ||
| 27 | FIL Ltd | 78,618 | 3,476,000 | 0.41% | ||
| 28 | Bank of New York Mellon Corp | 77,067 | 3,407,000 | 0.40% | ||
| 29 | AWM Investment Company, Inc. | 74,000 | 3,272,000 | 0.38% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,262 | 2,886,000 | 0.34% | ||
| 31 | Invesco Ltd. | 55,630 | 2,460,000 | 0.29% | ||
| 32 | A.R.T. Advisors, LLC | 54,434 | 2,407,000 | 0.28% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 46,731 | 2,309,000 | 0.27% | ||
| 34 | BlackRock Investment Management, LLC | 50,495 | 2,233,000 | 0.26% | ||
| 35 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,250 | 2,222,000 | 0.26% | ||
| 36 | RK Capital Management, LLC | 49,630 | 2,195,000 | 0.26% | ||
| 37 | DRIEHAUS CAPITAL MANAGEMENT LLC | 47,795 | 2,113,000 | 0.25% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 47,300 | 2,092,000 | 0.25% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 45,008 | 1,990,000 | 0.23% | ||
| 40 | HOWLAND CAPITAL MANAGEMENT LLC | 44,638 | 1,974,000 | 0.23% | ||
| 41 | CREDIT SUISSE AG/ | 33,179 | 1,467,000 | 0.17% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,510 | 1,261,000 | 0.15% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,000 | 1,062,000 | 0.12% | ||
| 44 | RUSSELL FRANK CO/ | 23,324 | 1,036,000 | 0.12% | ||
| 45 | GAGNON SECURITIES LLC | 22,629 | 1,001,000 | 0.12% | ||
| 46 | Informed Momentum Co LLC | 22,209 | 982,000 | 0.12% | ||
| 47 | TEACHERS ADVISORS, LLC | 21,120 | 934,000 | 0.11% | ||
| 48 | AQR CAPITAL MANAGEMENT LLC | 20,500 | 907,000 | 0.11% | ||
| 49 | RHUMBLINE ADVISERS | 18,926 | 837,000 | 0.10% | ||
| 50 | SOPHROSYNE CAPITAL LLC | 17,300 | 767,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
