| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,043,350 | 140,426,000 | 17.46% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 3,188,299 | 110,730,000 | 13.77% | ||
| 3 | JENNISON ASSOCIATES LLC | 2,579,426 | 89,583,000 | 11.14% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,526,800 | 87,756,000 | 10.91% | ||
| 5 | ORBIS HOLDINGS LTD | 1,000,467 | 34,746,000 | 4.32% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 780,440 | 27,105,000 | 3.37% | ||
| 7 | STATE STREET CORP | 749,917 | 26,047,000 | 3.24% | ||
| 8 | VANGUARD GROUP INC | 645,052 | 22,403,000 | 2.79% | ||
| 9 | BlackRock Fund Advisors | 465,827 | 16,178,000 | 2.01% | ||
| 10 | Cormorant Asset Management, LP | 462,720 | 16,070,000 | 2.00% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 438,672 | 15,235,000 | 1.89% | ||
| 12 | FRANKLIN RESOURCES INC | 426,754 | 14,821,000 | 1.84% | ||
| 13 | BBT Capital Management, LLC | 422,800 | 14,684,000 | 1.83% | ||
| 14 | Asset Management One Co., Ltd. | 384,474 | 14,679,000 | 1.83% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 407,108 | 14,139,000 | 1.76% | ||
| 16 | Third Security, LLC | 373,224 | 12,962,000 | 1.61% | ||
| 17 | CITADEL ADVISORS LLC | 286,372 | 9,945,000 | 1.24% | ||
| 18 | MORGAN STANLEY | 246,134 | 8,549,000 | 1.06% | ||
| 19 | Deer VII & Co. Ltd. | 239,203 | 8,308,000 | 1.03% | ||
| 20 | COLUMBUS CIRCLE INVESTORS | 237,865 | 8,261,000 | 1.03% | ||
| 21 | JPMORGAN CHASE & CO | 218,634 | 7,594,000 | 0.94% | ||
| 22 | RK Capital Management, LLC | 179,474 | 6,233,000 | 0.78% | ||
| 23 | NORTHERN TRUST CORP | 173,975 | 6,042,000 | 0.75% | ||
| 24 | HOWLAND CAPITAL MANAGEMENT LLC | 171,399 | 5,953,000 | 0.74% | ||
| 25 | FIL Ltd | 163,892 | 5,692,000 | 0.71% | ||
| 26 | Granahan Investment Management, LLC | 141,300 | 4,907,000 | 0.61% | ||
| 27 | SABBY MANAGEMENT, LLC | 2,074,736 | 4,693,000 | 0.58% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 130,998 | 4,549,000 | 0.57% | ||
| 29 | D. E. Shaw & Co., Inc. | 119,914 | 4,165,000 | 0.52% | ||
| 30 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 114,433 | 3,975,000 | 0.49% | ||
| 31 | Catalyst Capital Advisors LLC | 104,647 | 3,634,000 | 0.45% | ||
| 32 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 100,000 | 3,473,000 | 0.43% | Call | |
| 33 | ArrowMark Colorado Holdings LLC | 80,771 | 2,805,000 | 0.35% | ||
| 34 | Bank of New York Mellon Corp | 79,430 | 2,758,000 | 0.34% | ||
| 35 | Invesco Ltd. | 71,761 | 2,492,000 | 0.31% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 70,482 | 2,448,000 | 0.30% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 46,731 | 2,309,000 | 0.29% | ||
| 38 | CREDIT SUISSE AG/ | 65,997 | 2,292,000 | 0.29% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 58,300 | 2,025,000 | 0.25% | ||
| 40 | BlackRock Investment Management, LLC | 56,697 | 1,969,000 | 0.24% | ||
| 41 | Polar Asset Management Partners Inc. | 50,000 | 1,736,000 | 0.22% | Call | |
| 42 | Trexquant Investment LP | 49,899 | 1,732,000 | 0.22% | ||
| 43 | DENVER INVESTMENT ADVISORS LLC | 45,044 | 1,564,000 | 0.19% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,900 | 1,351,000 | 0.17% | Put | |
| 45 | PNC FINANCIAL SERVICES GROUP, INC. | 36,934 | 1,282,000 | 0.16% | ||
| 46 | GSA CAPITAL PARTNERS LLP | 32,843 | 1,141,000 | 0.14% | ||
| 47 | Spark Investment Management LLC | 32,400 | 1,124,000 | 0.14% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,510 | 1,094,000 | 0.14% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,400 | 1,056,000 | 0.13% | ||
| 50 | A.R.T. Advisors, LLC | 28,074 | 975,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
