| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,178,200 | 76,482,000 | 13.36% | ||
| 2 | FMR LLC | 5,008,850 | 73,981,000 | 12.93% | ||
| 3 | QVT Financial LP | 1,866,782 | 26,816,000 | 4.69% | ||
| 4 | STATE STREET CORP | 1,703,937 | 25,166,000 | 4.40% | ||
| 5 | VANGUARD GROUP INC | 1,650,539 | 24,379,000 | 4.26% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 1,480,337 | 21,865,000 | 3.82% | ||
| 7 | FRANKLIN RESOURCES INC | 1,370,800 | 20,247,000 | 3.54% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 1,247,495 | 18,426,000 | 3.22% | ||
| 9 | BlackRock Fund Advisors | 1,241,184 | 18,332,000 | 3.20% | ||
| 10 | BAKER BROS. ADVISORS LP | 1,230,802 | 18,179,000 | 3.18% | ||
| 11 | CITADEL ADVISORS LLC | 1,064,884 | 15,728,000 | 2.75% | ||
| 12 | JPMORGAN CHASE & CO | 1,056,817 | 15,609,000 | 2.73% | ||
| 13 | Visium Asset Management, LP | 1,041,286 | 15,380,000 | 2.69% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 945,983 | 13,972,000 | 2.44% | ||
| 15 | Cormorant Asset Management, LP | 900,000 | 13,293,000 | 2.32% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 819,500 | 12,104,000 | 2.11% | Call | |
| 17 | BNP Paribas Asset Management Holding S.A. | 812,614 | 12,002,000 | 2.10% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 809,600 | 11,958,000 | 2.09% | Put | |
| 19 | NORTHERN TRUST CORP | 586,026 | 8,655,000 | 1.51% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 573,617 | 8,472,000 | 1.48% | ||
| 21 | AMERIPRISE FINANCIAL INC | 528,496 | 7,805,000 | 1.36% | ||
| 22 | DEUTSCHE BANK AG\ | 487,309 | 7,196,000 | 1.26% | ||
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 484,875 | 7,161,000 | 1.25% | ||
| 24 | LORD, ABBETT & CO. LLC | 456,687 | 6,745,000 | 1.18% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 299,223 | 4,420,000 | 0.77% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 290,851 | 4,295,000 | 0.75% | ||
| 27 | FRED ALGER MANAGEMENT, LLC | 287,749 | 4,250,000 | 0.74% | ||
| 28 | Jefferies Group LLC | 284,000 | 4,195,000 | 0.73% | Put | |
| 29 | Bank of New York Mellon Corp | 274,185 | 4,050,000 | 0.71% | ||
| 30 | D. E. Shaw & Co., Inc. | 266,200 | 3,932,000 | 0.69% | ||
| 31 | TEACHERS ADVISORS, LLC | 256,835 | 3,793,000 | 0.66% | ||
| 32 | DRIEHAUS CAPITAL MANAGEMENT LLC | 190,762 | 2,818,000 | 0.49% | ||
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 181,059 | 2,674,000 | 0.47% | ||
| 34 | Asset Management One Co., Ltd. | 160,303 | 2,412,000 | 0.42% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 162,915 | 2,406,000 | 0.42% | ||
| 36 | BlackRock Investment Management, LLC | 150,714 | 2,226,000 | 0.39% | ||
| 37 | TURNER INVESTMENTS LLC | 139,940 | 2,067,000 | 0.36% | ||
| 38 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 135,141 | 1,996,000 | 0.35% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 130,847 | 1,933,000 | 0.34% | ||
| 40 | UBS AG | 128,056 | 1,891,000 | 0.33% | ||
| 41 | CREDIT SUISSE AG/ | 123,800 | 1,828,000 | 0.32% | ||
| 42 | Allianz Asset Management GmbH | 119,237 | 1,761,000 | 0.31% | ||
| 43 | MARXE AUSTIN W & GREENHOUSE DAVID M | 118,733 | 1,754,000 | 0.31% | ||
| 44 | WALL STREET ASSOCIATES | 117,387 | 1,734,000 | 0.30% | ||
| 45 | Rock Springs Capital Management LP | 115,000 | 1,699,000 | 0.30% | ||
| 46 | EVENTIDE ASSET MANAGEMENT, LLC | 114,700 | 1,694,000 | 0.30% | ||
| 47 | Jefferies Group LLC | 111,239 | 1,643,000 | 0.29% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 95,644 | 1,413,000 | 0.25% | ||
| 49 | Informed Momentum Co LLC | 94,440 | 1,395,000 | 0.24% | ||
| 50 | Iguana Healthcare Management, LLC | 90,000 | 1,330,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
