| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,520,950 | 90,654,000 | 13.82% | ||
| 2 | ORBIMED ADVISORS LLC | 3,910,000 | 64,202,000 | 9.79% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,941,916 | 48,306,000 | 7.37% | ||
| 4 | SAC Capital Advisors LP | 2,740,000 | 44,991,000 | 6.86% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 2,225,175 | 36,537,000 | 5.57% | ||
| 6 | QVT Financial LP | 2,024,782 | 32,406,000 | 4.94% | ||
| 7 | FRANKLIN RESOURCES INC | 1,690,600 | 27,760,000 | 4.23% | ||
| 8 | MARXE AUSTIN W & GREENHOUSE DAVID M | 1,283,088 | 21,068,000 | 3.21% | ||
| 9 | VANGUARD GROUP INC | 1,219,338 | 20,022,000 | 3.05% | ||
| 10 | Visium Asset Management, LP | 1,217,183 | 19,987,000 | 3.05% | ||
| 11 | Cormorant Asset Management, LP | 1,000,000 | 16,420,000 | 2.50% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 818,668 | 13,443,000 | 2.05% | ||
| 13 | STATE STREET CORP | 785,110 | 12,891,000 | 1.97% | ||
| 14 | JENNISON ASSOCIATES LLC | 776,746 | 12,754,000 | 1.94% | ||
| 15 | JANUS HENDERSON INVESTORS US LLC | 772,020 | 12,677,000 | 1.93% | ||
| 16 | BAKER BROS. ADVISORS LP | 732,062 | 12,020,000 | 1.83% | ||
| 17 | Bain Capital Public Equity Management, LLC | 717,500 | 11,781,000 | 1.80% | ||
| 18 | AMERIPRISE FINANCIAL INC | 701,247 | 11,515,000 | 1.76% | ||
| 19 | JPMORGAN CHASE & CO | 673,263 | 11,056,000 | 1.69% | ||
| 20 | Artisan Partners Limited Partnership | 657,723 | 10,800,000 | 1.65% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 642,552 | 10,551,000 | 1.61% | ||
| 22 | HealthCor Management, L.P. | 450,000 | 7,389,000 | 1.13% | ||
| 23 | SIGMA CAPITAL MANAGEMENT LLC | 400,000 | 6,568,000 | 1.00% | ||
| 24 | GOLDMAN SACHS GROUP INC | 364,000 | 5,977,000 | 0.91% | Call | |
| 25 | BNP Paribas Asset Management Holding S.A. | 320,941 | 5,270,000 | 0.80% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 317,300 | 5,210,000 | 0.79% | ||
| 27 | WEXFORD CAPITAL LP | 307,100 | 5,043,000 | 0.77% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 248,700 | 4,084,000 | 0.62% | Put | |
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 236,340 | 3,881,000 | 0.59% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,500 | 3,621,000 | 0.55% | Call | |
| 31 | JANE STREET GROUP, LLC | 216,770 | 3,559,000 | 0.54% | ||
| 32 | LORD, ABBETT & CO. LLC | 207,410 | 3,406,000 | 0.52% | ||
| 33 | Ghost Tree Capital, LLC | 185,000 | 3,038,000 | 0.46% | ||
| 34 | MORGAN STANLEY | 177,469 | 2,914,000 | 0.44% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 177,120 | 2,908,000 | 0.44% | ||
| 36 | DRIEHAUS CAPITAL MANAGEMENT LLC | 173,404 | 2,847,000 | 0.43% | ||
| 37 | Hood River Capital Management LLC | 163,930 | 2,692,000 | 0.41% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 150,000 | 2,463,000 | 0.38% | Call | |
| 39 | D. E. Shaw & Co., Inc. | 147,030 | 2,414,000 | 0.37% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 140,660 | 2,310,000 | 0.35% | ||
| 41 | PANAGORA ASSET MANAGEMENT INC | 129,041 | 2,119,000 | 0.32% | ||
| 42 | Informed Momentum Co LLC | 126,857 | 2,083,000 | 0.32% | ||
| 43 | BlackRock Fund Advisors | 123,355 | 2,025,000 | 0.31% | ||
| 44 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 121,630 | 1,997,165 | 0.30% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 106,599 | 1,750,000 | 0.27% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 94,847 | 1,554,000 | 0.24% | ||
| 47 | Weiss Multi-Strategy Advisers LLC | 80,000 | 1,314,000 | 0.20% | ||
| 48 | UBS AG | 76,429 | 1,255,000 | 0.19% | ||
| 49 | Rock Springs Capital Management LP | 75,000 | 1,232,000 | 0.19% | ||
| 50 | TURNER INVESTMENTS LLC | 74,800 | 1,228,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
