| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 6,450,000 | 34,637,000 | 13.48% | ||
| 2 | FMR LLC | 4,463,302 | 23,968,000 | 9.33% | ||
| 3 | VANGUARD GROUP INC | 3,397,625 | 18,246,000 | 7.10% | ||
| 4 | BlackRock Fund Advisors | 3,330,692 | 17,886,000 | 6.96% | ||
| 5 | Sarissa Capital Management LP | 2,875,000 | 15,438,000 | 6.01% | ||
| 6 | GOLDMAN SACHS GROUP INC | 2,753,499 | 14,786,000 | 5.75% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,223,444 | 11,940,000 | 4.65% | ||
| 8 | D. E. Shaw & Co., Inc. | 1,951,155 | 10,478,000 | 4.08% | ||
| 9 | STATE STREET CORP | 1,947,089 | 10,454,000 | 4.07% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,362,118 | 7,315,000 | 2.85% | ||
| 11 | Atika Capital Management LLC | 1,358,000 | 7,292,000 | 2.84% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,288,685 | 6,920,000 | 2.69% | ||
| 13 | HealthCor Management, L.P. | 1,051,315 | 5,646,000 | 2.20% | ||
| 14 | NORTHERN TRUST CORP | 1,000,907 | 5,376,000 | 2.09% | ||
| 15 | GREAT POINT PARTNERS LLC | 978,350 | 5,254,000 | 2.04% | ||
| 16 | SV Health Investors, LLC | 888,132 | 4,769,000 | 1.86% | ||
| 17 | DEUTSCHE BANK AG\ | 717,543 | 3,852,000 | 1.50% | ||
| 18 | Ghost Tree Capital, LLC | 600,000 | 3,222,000 | 1.25% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 593,892 | 3,189,000 | 1.24% | ||
| 20 | Bank of New York Mellon Corp | 455,391 | 2,446,000 | 0.95% | ||
| 21 | JPMORGAN CHASE & CO | 449,409 | 2,413,000 | 0.94% | ||
| 22 | Atika Capital Management LLC | 446,000 | 2,393,000 | 0.93% | Call | |
| 23 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 431,801 | 2,318,000 | 0.90% | ||
| 24 | PICTET ASSET MANAGEMENT LTD | 413,067 | 2,284,000 | 0.89% | ||
| 25 | GROUP ONE TRADING LLC | 379,484 | 2,038,000 | 0.79% | ||
| 26 | Allianz Asset Management GmbH | 360,372 | 1,935,000 | 0.75% | ||
| 27 | BALYASNY ASSET MANAGEMENT L.P. | 338,620 | 1,818,000 | 0.71% | ||
| 28 | BlackRock Investment Management, LLC | 330,867 | 1,777,000 | 0.69% | ||
| 29 | BLACKROCK ADVISORS LLC | 271,894 | 1,460,000 | 0.57% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 269,356 | 1,446,000 | 0.56% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 263,274 | 1,414,000 | 0.55% | ||
| 32 | GLOBEFLEX CAPITAL L P | 212,739 | 1,142,000 | 0.44% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 209,309 | 1,124,000 | 0.44% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 179,348 | 963,000 | 0.37% | ||
| 35 | TURNER INVESTMENTS LLC | 177,530 | 953,000 | 0.37% | ||
| 36 | ACUTA CAPITAL PARTNERS, LLC | 174,708 | 938,000 | 0.36% | ||
| 37 | JACOBS LEVY EQUITY MANAGEMENT, INC | 167,700 | 901,000 | 0.35% | ||
| 38 | PDT Partners, LLC | 157,500 | 846,000 | 0.33% | ||
| 39 | TEACHERS ADVISORS, LLC | 136,963 | 735,000 | 0.29% | ||
| 40 | TFS CAPITAL LLC | 135,382 | 727,000 | 0.28% | ||
| 41 | Swiss National Bank | 132,600 | 712,000 | 0.28% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 130,200 | 699,000 | 0.27% | Put | |
| 43 | AMERIPRISE FINANCIAL INC | 125,860 | 676,000 | 0.26% | ||
| 44 | UBS Group AG | 113,018 | 607,000 | 0.24% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 109,460 | 588,000 | 0.23% | ||
| 46 | TUDOR INVESTMENT CORP ET AL | 108,286 | 581,000 | 0.23% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 103,500 | 556,000 | 0.22% | ||
| 48 | VIRTUS ETF ADVISERS LLC | 99,654 | 535,000 | 0.21% | ||
| 49 | RHUMBLINE ADVISERS | 97,095 | 521,000 | 0.20% | ||
| 50 | Quantitative Systematic Strategies LLC | 92,474 | 495,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
