| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,935,499 | 210,900,000 | 14.92% | ||
| 2 | FRANKLIN RESOURCES INC | 9,883,257 | 174,636,000 | 12.35% | ||
| 3 | OppenheimerFunds, Inc. | 5,785,451 | 102,229,000 | 7.23% | ||
| 4 | VANGUARD GROUP INC | 5,083,094 | 89,818,000 | 6.35% | ||
| 5 | JENNISON ASSOCIATES LLC | 3,488,319 | 61,639,000 | 4.36% | ||
| 6 | BlackRock Fund Advisors | 3,350,054 | 59,195,000 | 4.19% | ||
| 7 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 2,672,000 | 47,214,000 | 3.34% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,459,141 | 43,453,000 | 3.07% | ||
| 9 | STATE STREET CORP | 2,352,973 | 41,579,000 | 2.94% | ||
| 10 | ORBIMED ADVISORS LLC | 2,347,600 | 41,482,000 | 2.93% | ||
| 11 | TimesSquare Capital Management, LLC | 2,164,918 | 38,254,000 | 2.71% | ||
| 12 | SAC Capital Advisors LP | 1,818,631 | 32,135,000 | 2.27% | ||
| 13 | COLUMBUS CIRCLE INVESTORS | 1,766,841 | 31,220,000 | 2.21% | ||
| 14 | SECTORAL ASSET MANAGEMENT INC | 1,408,908 | 24,895,000 | 1.76% | ||
| 15 | NORTHERN TRUST CORP | 1,167,655 | 20,633,000 | 1.46% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 958,000 | 16,928,000 | 1.20% | Put | |
| 17 | DIMENSIONAL FUND ADVISORS LP | 954,784 | 16,874,000 | 1.19% | ||
| 18 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 870,315 | 15,378,000 | 1.09% | ||
| 19 | Redmile Group, LLC | 863,947 | 15,266,000 | 1.08% | ||
| 20 | ALLIANCEBERNSTEIN L.P. | 812,534 | 14,357,000 | 1.02% | ||
| 21 | TSP Capital Management Group, LLC | 811,342 | 14,336,000 | 1.01% | PRN | |
| 22 | MORGAN STANLEY | 746,754 | 13,195,000 | 0.93% | ||
| 23 | FRED ALGER MANAGEMENT, LLC | 729,959 | 12,898,000 | 0.91% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 717,578 | 12,679,000 | 0.90% | ||
| 25 | Invesco Ltd. | 660,767 | 11,676,000 | 0.83% | ||
| 26 | APEX CAPITAL, LLC | 515,000 | 9,100,000 | 0.64% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 511,900 | 9,045,000 | 0.64% | Call | |
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 505,798 | 8,937,000 | 0.63% | ||
| 29 | DEUTSCHE BANK AG\ | 488,377 | 8,628,000 | 0.61% | ||
| 30 | NEW YORK STATE COMMON RETIREMENT FUND | 473,650 | 8,369,000 | 0.59% | ||
| 31 | LORD, ABBETT & CO. LLC | 467,952 | 8,269,000 | 0.58% | ||
| 32 | Bank of New York Mellon Corp | 459,940 | 8,127,000 | 0.57% | ||
| 33 | State of New Jersey Common Pension Fund A | 410,000 | 7,245,000 | 0.51% | ||
| 34 | ARDSLEY ADVISORY PARTNERS LP | 409,500 | 7,236,000 | 0.51% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 386,200 | 6,824,000 | 0.48% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 370,353 | 6,544,000 | 0.46% | ||
| 37 | AMERIPRISE FINANCIAL INC | 355,785 | 6,288,000 | 0.44% | ||
| 38 | CAPITAL FUND MANAGEMENT S.A. | 306,608 | 5,418,000 | 0.38% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 288,700 | 5,101,000 | 0.36% | ||
| 40 | Capital World Investors | 287,000 | 5,071,000 | 0.36% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 259,900 | 4,592,000 | 0.32% | ||
| 42 | BlackRock Investment Management, LLC | 249,940 | 4,416,000 | 0.31% | ||
| 43 | CREDIT SUISSE AG/ | 247,108 | 4,366,000 | 0.31% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 238,364 | 4,212,000 | 0.30% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 235,908 | 4,169,000 | 0.29% | ||
| 46 | STIFEL FINANCIAL CORP | 233,930 | 4,133,000 | 0.29% | ||
| 47 | GOLDMAN SACHS GROUP INC | 231,726 | 4,094,000 | 0.29% | ||
| 48 | GROUP ONE TRADING LLC | 219,769 | 3,883,000 | 0.27% | ||
| 49 | Iguana Healthcare Management, LLC | 215,000 | 3,799,000 | 0.27% | ||
| 50 | TEACHERS ADVISORS, LLC | 212,195 | 3,749,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
