| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 15,396,174 | 372,279,000 | 17.44% | ||
| 2 | ORBIMED ADVISORS LLC | 8,245,111 | 199,367,000 | 9.34% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,171,486 | 197,587,000 | 9.26% | ||
| 4 | VANGUARD GROUP INC | 6,309,119 | 152,554,000 | 7.15% | ||
| 5 | Invesco Ltd. | 4,085,784 | 98,794,000 | 4.63% | ||
| 6 | BRIDGER MANAGEMENT, LLC | 2,673,193 | 64,638,000 | 3.03% | ||
| 7 | BlackRock Fund Advisors | 2,414,261 | 58,377,000 | 2.73% | ||
| 8 | Fisher Asset Management, LLC | 2,358,437 | 57,027,000 | 2.67% | ||
| 9 | WESTFIELD CAPITAL MANAGEMENT CO LP | 2,251,539 | 54,442,000 | 2.55% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,203,458 | 53,280,000 | 2.50% | ||
| 11 | Palo Alto Investors LP | 2,132,157 | 51,556,000 | 2.41% | ||
| 12 | STATE STREET CORP | 1,494,406 | 35,884,000 | 1.68% | ||
| 13 | Epoch Investment Partners, Inc. | 1,478,019 | 35,739,000 | 1.67% | ||
| 14 | GW&K Investment Management, LLC | 1,299,009 | 31,410,000 | 1.47% | ||
| 15 | Point72 Asset Management, L.P. | 1,272,900 | 30,779,000 | 1.44% | ||
| 16 | GOLDMAN SACHS GROUP INC | 1,270,793 | 30,728,000 | 1.44% | ||
| 17 | DEUTSCHE BANK AG\ | 1,170,814 | 28,308,000 | 1.33% | ||
| 18 | NORTHERN TRUST CORP | 1,139,311 | 27,549,000 | 1.29% | ||
| 19 | CITADEL ADVISORS LLC | 956,034 | 23,116,000 | 1.08% | ||
| 20 | BALYASNY ASSET MANAGEMENT L.P. | 925,690 | 22,383,000 | 1.05% | ||
| 21 | JANUS HENDERSON INVESTORS US LLC | 917,972 | 22,197,000 | 1.04% | ||
| 22 | DIMENSIONAL FUND ADVISORS LP | 874,411 | 21,142,000 | 0.99% | ||
| 23 | D. E. Shaw & Co., Inc. | 829,370 | 20,054,000 | 0.94% | ||
| 24 | JPMORGAN CHASE & CO | 787,006 | 19,029,000 | 0.89% | ||
| 25 | Elk Creek Partners, LLC | 746,741 | 18,056,000 | 0.85% | ||
| 26 | Pine River Capital Management L.P. | 713,690 | 17,257,000 | 0.81% | ||
| 27 | NORGES BANK | 703,815 | 17,018,000 | 0.80% | ||
| 28 | WELLS FARGO & COMPANY/MN | 701,546 | 16,963,000 | 0.79% | ||
| 29 | FEDERATED HERMES, INC. | 601,377 | 14,542,000 | 0.68% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 592,209 | 14,319,000 | 0.67% | ||
| 31 | SEGALL BRYANT & HAMILL, LLC | 584,299 | 14,128,000 | 0.66% | ||
| 32 | TWO SIGMA ADVISERS, LP | 522,800 | 12,641,000 | 0.59% | ||
| 33 | MORGAN STANLEY | 515,969 | 12,476,000 | 0.58% | ||
| 34 | STATE OF WISCONSIN INVESTMENT BOARD | 506,179 | 12,239,000 | 0.57% | ||
| 35 | Ghost Tree Capital, LLC | 500,000 | 12,090,000 | 0.57% | ||
| 36 | EverPoint Asset Management, LLC | 500,000 | 12,090,000 | 0.57% | ||
| 37 | NOMURA HOLDINGS INC | 468,811 | 11,347,000 | 0.53% | ||
| 38 | Foundation Asset Management, LP | 463,602 | 11,210,000 | 0.53% | ||
| 39 | Rock Springs Capital Management LP | 456,000 | 11,026,000 | 0.52% | ||
| 40 | BLUE JAY CAPITAL MANAGEMENT, LLC | 450,000 | 10,881,000 | 0.51% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 448,186 | 10,837,000 | 0.51% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 445,084 | 10,762,000 | 0.50% | ||
| 43 | Bank of New York Mellon Corp | 421,327 | 10,188,000 | 0.48% | ||
| 44 | FOLGER HILL ASSET MANAGEMENT LP | 376,461 | 9,103,000 | 0.43% | ||
| 45 | ARROWGRASS CAPITAL PARTNERS (US) LP | 340,508 | 8,233,000 | 0.39% | ||
| 46 | AXA S.A. | 326,575 | 7,897,000 | 0.37% | ||
| 47 | BlackRock Investment Management, LLC | 315,574 | 7,631,000 | 0.36% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 303,211 | 7,332,000 | 0.34% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 293,044 | 7,086,000 | 0.33% | ||
| 50 | Visium Asset Management, LP | 276,503 | 6,686,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
